Congrats to Jing @jesszhiyuezhao.bsky.social‬ & @dnamystrom.bsky.social‬ on cool manuscript!!! Reveals how cell nucleus is a heterogeneous material, w chromatin organization controlling formation & phase behavior of nuclear condensates. #CellBiology #Chromatin #PhaseSeparation rdcu.be/evWxR

Chromatin heterogeneity modulates nuclear condensate dynamics and phase behavior

Nature Communications - Chromatin heterogeneity in the cell nucleus modulates the size, mobility, and formation of biomolecular condensates; decreasing chromatin heterogeneity correlates with...

rdcu.be

We are happy to share our work on local #nucleosome dynamics integrating #temperature inputs into an #epigenetic switching mechanism. ⚠️ Preprint alert!! www.biorxiv.org/content/10.1...

Cold-induced nucleosome dynamics linked to silencing of Arabidopsis FLC

Temperature influences nucleosome dynamics, and thus chromatin, to regulate gene expression. Such mechanisms underlie the epigenetic silencing of Arabidopsis FLOWERING LOCUS C (FLC) by prolonged cold....

biorxiv.org

Our paper has been published! We used in vivo single-particle tracking to demonstrate that the assembly of core FCA oligomers into functional macromolecular condensates. Thanks to all the authors and colleagues!

The EMBO Journal@embojournal.org · 2y ago

In vivo single-particle tracking by Geng-Jen Jang, Caroline Dean et al reveals the modular assembly of #Arabidopsis gene expression regulator FLOWERING CONTROL LOCUS A from oligomers into molecular condensates competent for RNA 3’-processing www.embopress.org/doi/full/10....