How do epithelial cells integrate mechanical and biochemical signals to control their behavior? I am @ronjahoutekamer.bsky.social, and in this thread, I’ll show you how force transduction connects to biochemical signaling, and how it activates ERK by inducing biochemical ligand shedding.

Paper alert! β-catenin forms condensates that help build cell–cell adhesions - showing its role goes beyond simply linking E-cadherin to α-cat/actin. Great collaboration with the Schuijers lab! 👉 nature.com/articles/s41...

We finally made it over here ! And excited to share our new paper on mechanical forces regulating stem cell plasticity in colorectal cancer, involving force transduction via mechanosensitive calcium channels! www.cell.com/cell-reports...

Mechanosensitive calcium channels and integrins coordinate the reprogramming of colorectal cancer cells into a fetal-like state

van der Net et al. show that mechanical interactions with the stromal component collagen I trigger reprogramming of colorectal cancer cells into a fetal-like state, through mechanosensitive integrins ...

cell.com