Tessera

Huge congratulations to Leon Schlosser on defending his PhD! From lab discussions to race days, it’s been a pleasure sharing the journey. EnTDecker is an amazing legacy to leave behind, and we can’t wait to see what you’ll build next. Wishing you all the best for your next chapter! 🏃🏻‍♂️🧪🚀 #PhDone

Two weeks ago, the @gloriusgroup.bsky.social joined #BOS2026 in Tallinn for inspiring talks, great posters, and insightful discussions. Congrats to Julius Domagk on his housane synthesis talk! Thanks to the organizers—see you in Vilnius for #BOS2028! 🏠👏

Simple building blocks, complex 3D heterocycles. In our new JACS study, synergistic photoredox/Cr/Lewis acid catalysis enables modular access to densely substituted THF, forming four new bonds and up to four stereocenters with high selectivity. Link to paper: pubs.acs.org/doi/10.1021/...

Highly Selective and Modular Assembly of Densely Substituted Tetrahydrofurans

Densely substituted heterocycles are ubiquitous motifs in both natural products and pharmaceuticals. sp3-Heterocycles bearing multiple vicinal stereocenters are especially critical targets due to their challenging construction under precise stereocontrol. The multisubstituted tetrahydrofuran (THF) family, for example, represents a privileged structural motif. Yet, syntheses of THFs are often step-intensive and tailored to a single target structure, as generalized and robust methods that rapidly introduce multiple substituents from simple precursors remain underdeveloped. Herein, we present a distinct approach featuring two core advantages: modular assembly from abundant building blocks, and precise chemo-, regio-, diastereo-, and enantioselectivity. Pivotal to the success of this methodology is synergistic metallaphotoredox–Lewis acid catalysis, which rapidly constructs four bonds in THFs bearing up to four stereocenters. Experimental and computational studies deliver further insight into the mechanism. High-throughput experimentation (HTE) highlights the potential for efficient generation of THF-based libraries.

pubs.acs.org

Glorius Group @gloriusgroup.bsky.social · 4w ago

Highly Selective and Modular Assembly of Densely Substituted Tetrahydrofurans

pubs.acs.org

Represented Glorius Group's research at #BOSSXIX in Leuven! 🇧🇪 Phenomenal week sharing scientific insights and connecting with pioneers.🧪✨ A definite highlight was to connect with Prof. Scott E. Denmark and Prof. Véronique Gouverneur. #OrganicChemistry #Synthesis #Networking

Glorius Group @gloriusgroup.bsky.social · 4w ago

TRIPLE Triplet Triplet EnT catalysis in one pot —wondering how??😃 Dearomative [5+4] cycloaddition -> formal [3,3]-sigmatropic rearrangement ->[2+2] cycloaddition of bicyclic azaarenes to access unique pyridine fused/bridged pentacyclic products. www.nature.com/articles/s41...

Triple energy transfer-enabled dearomative cycloaddition/rearrangement cascade of bicyclic azaarenes to structurally complex products - Nature Catalysis

Energy transfer (EnT) catalysed dearomative cycloadditions of bicyclic azaarenes are largely limited to [4+2] pathways, with higher-order cycloadditions being difficult to achieve. Now, the authors ci...

nature.com

Congratulations to Nele Van Wyngaerden on the successful defense of her PhD last week! 🎓 Nele's research focused on developing innovative imidazolium-based cholesterol analogues for novel applications. We wish you all the best in the exciting journey ahead! 🎉

Proud moment! Dr. Ayan Jati met German President Frank-Walter Steinmeier & Prof. Dr. Robert Schlögl at the 2026 @AvHStiftung Annual Meeting. A wonderful event celebrating scientific excellence and international collaboration. Congrats, Ayan! 🌍✨ #AvH2026 #Humboldt

Huge congratulations to Hung for winning a poster prize at #AI4XAccelerate2026, presenting our work in calibration-free GC-MS/FID with automated data analysis through the pyGecko package 🦎! Check out the publication here! doi.org/10.1039/D4DD...

Excited to share another milestone in @angewandtechemie.bsky.social ! 🎉 We developed a mild, selective visible-light Birch-type reduction of 2-pyridones via EnT catalysis & sequential HAT, backed by computational insights. Huge thanks to the team! 🙌 onlinelibrary.wiley.com/doi/10.1002/...

Energy‐Transfer Catalysis Enables the Birch‐Type Reduction of 2‐Pyridones

In this study, a mild and selective visible-light-mediated Birch-type reduction of 2-pyridones has been developed. This protocol proved to tolerate a vast number of functional groups, which was achie...

onlinelibrary.wiley.com

Excited to share our new work in JACS! 📚 We use energy transfer activation of furans & oxazoles to generate distinct 1,4-biradicals. These undergo (5+4) cycloaddition with VCPs for rapid synthesis of heterobicyclo[5.2.1]decane scaffolds. Paper: pubs.acs.org/doi/10.1021/... #Photocatalysis #Chemistry

Accessing Medium-Sized Bridged Heterocycles via EnT-Catalyzed Intermolecular Dearomative (5 + 4) Cycloaddition of Furans and Oxazoles

Medium-sized bridged heterocycles are highly attractive structural motifs in bioactive natural products and medicinal chemistry. However, their broader exploration remains limited due to the lack of concise and modular synthetic strategies, as their synthesis is challenged by unfavorable enthalpic and entropic constraints. Herein, we report an energy transfer (EnT)-catalyzed intermolecular (5 + 4) dearomative cycloaddition of furans with vinyl cyclopropanes, providing direct access to (Z)-10-oxabicyclo[5.2.1]deca-3,8-diene scaffolds in a single step. Visible light triplet sensitization unlocks a distinct diene-type 1,4-biradical activation mode in furans. This triplet-state reactivity enables intermolecular higher-order (5 + 4) cycloadditions that remain inaccessible under conventional thermal activation. Mechanistic investigations support an energy transfer pathway and provide insights into the origin of the observed regioselectivity. The resulting partially unsaturated cycloadducts offer multiple synthetic handles for downstream functionalization, enabling rapid and modular incorporation of heterobicyclo[5.2.1]alkane motifs and highlighting their potential as versatile building blocks in synthetic chemistry.

pubs.acs.org

🔋 Exciting week at #IMLB in Montréal! Marc Jaspers & Steffen Heuvel are connecting with the global battery community. 🤝 The big takeaway: innovations in organic materials are a key driver for next-gen energy storage. ⚗️⚡ #EnergyStorage #OrganicChemistry #MaterialsScience

Last weekend, @sophiekorgitzsch.bsky.social attended Alpenforum 2026 by @JCF_Muenchen ! 🏔️ Three days of invaluable career insights from industry speakers & networking in beautiful Garmisch-Partenkirchen. Thanks to the organizers & speakers! 👏 #Alpenforum2026 #GDCh #Networking

Attended the 14th ISOFR in Bologna, Italy with Indrasish Dey, Niklas Hölter, Paulina Hartmann & Colin Stein! Great time showcasing Glorius Group research & talking #chemistry with brilliant researchers. 🧪 Thanks to the organizers & Prof. Paolo Melchiorre! 👏 #ISOFR #Research

The Glorius Group #MachineLearning is at #AI4XAccelerate2026 in Singapore! 🇸🇬 Two talks still to come Thu 18 Jun: MaikNiedziella (15:30, GC/MS Structure Elucidation) & Jan Spies (17:15, PU Learning). Plus posters 1.23, 2.8 at the Wed and 1.27 at the Thu session! 🤖🧪

From molecular precision to improved performance: NHC-functionalized step edges unlock enhanced electrochemical CO₂ reduction. Great teamwork with groups of Salas, Amirjalayer, Mönig. Now in Advanced Materials! 🔬⚡♻️ lnkd.in/eQw922x4 #NHCs #CO2Reduction #Catalysis

🌈Happy Pride Month! 🌈 This June, Glorius Group stands for equality, inclusion, and science without barriers. ✨ Great research thrives when everyone belongs. 🔬❤️ #PrideMonth #EqualScience #ScienceForAll #DiversityInSTEM

🧪 New paper in Angewandte Chemie (VIP)! 🎉 Our CHIM-NTA lipid analogue immobilizes enzymes on bacterial surfaces, enabling single-cell cascade reactions without genetic engineering. Congratulations to all the authors! lnkd.in/eKwApZbu #Biocatalysis #ChemicalBiology

🧪✨ A “named reaction” represents a lasting contribution to synthetic chemistry. We are delighted to see Glorius Late-Stage Saturation featured in the 7th edition of Name Reactions by Jie Jack Li 📘. 🔗 link.springer.com/chapter/10.1... #OrganicChemistry #GloriusGroup #Catalysis

Glorius Late-Stage Saturation

The desire to access molecules with three-dimensional structures is of great importance in drug discovery. Two decades of exploration in selective arene saturation have recently culminated in producti...

link.springer.com

🧪🌙 Science connects minds, Eid connects hearts. Eid Al Adha Mubarak from Glorius Lab ✨ #EidMubarak #GloriusLab #Research

In the Glorius Group, it’s not about making a statement for one day - it’s who we are. We stand for diversity, respect, equality, and visibility for all, and against any form of discrimination. 🌈🌏

Excited to see our work on aziridination of a single carbon atom in alkenes published in Angewandte Chemie. Energy transfer catalysis enabled the synthesis of highly substituted NH-aziridines with unconventional regioselectivity. Link to paper: onlinelibrary.wiley.com/doi/full/10....

Aziridination of a Single Carbon Atom in Alkenes via Energy Transfer Catalysis

Contrary to traditional alkene aziridination via (formal) nitrene transfer, we herein report a strategy that achieves intermolecular aziridination of a single alkene carbon atom and installs an addit...

onlinelibrary.wiley.com

Congratulations to Debanjan Rana on successfully defending his PhD today!🎓👏 From advancing photocatalysis to bridging it with machine learning, your work has been nothing short of inspiring. Wishing you all the best as you head to the UK for your postdoc! #PhDone

🧪 #WorldLabDay – Answer Reveal🧩 Thanks to everyone who took on our crossword challenge yesterday, and for exploring all the clues inspired by our research, our group, and life in the lab. Did you get them right? Let us know! #OrganicChemistry #ChemistryPuzzle