My last piece of work at the Wallace group. Please check it out and let us know what you think! 😀Thanks @jeffreypullin.bsky.social for summarising it!

Jeffrey Pullin@jeffreypullin.bsky.social · 3mo ago

tinyurl.com/reuxynmc Very excited to see this work I was a small part of published! We analysed two large scale colocalisation datasets: OpenTargets data and an analysis of immune-mediated disease GWAS/immune cell eQTLs seeking to understand the "colocalisation gap". Some highlights:

RápidoPGS is back on CRAN! I've fixed some dependency issues updated contact details, and it should now work fine. Please let me know if you have issues or comments! cran.r-project.org/web/packages...

RapidoPGS: A Fast and Light Package to Compute Polygenic Risk Scores

Quickly computes polygenic scores from GWAS summary statistics of either case-control or quantitative traits without parameter tuning. Reales,G., Vigorito, E., Kelemen,M., Wallace,C. (2021) &lt;<a hre...

cran.r-project.org

Hi folks! I'm looking for a new position in Statistical Genetics 🧬💻 around Cambridge (UK) or Spain. 🎓 PhD in Genetics + 6 year postdoc + ~1 year industry experience 💻 Expertise in R and data analysis 📣 Excellent communication, social, and collaboration skills Let's have a chat!

"Every gun that is made, every warship launched, every rocket fired signifies, in the final sense, a theft from those who hunger and are not fed, those who are cold and are not clothed."

I was today years old when I realized that the Chromosome 2 fusion event which is unique to modern humans probably coincides with a possible population bottleneck event ~900kya. Could the one have caused the other? This is my adaptation of the published figure DOI: 10.1126/science.abq7487

The most famous heuristic in mapping gwas snps to genes is "it's usually the closest gene". But only slightly less well-known is this: consider the colocalized phenotypes. That is, a genetic variant seldom disrupts exactly one phenotype. What else does tugging on that thread do?

I joined Will Dixon and the team at BBC’s Curious Cases to chat about how weather and seasons might influence inflammation and pain. A really fun conversation! www.bbc.co.uk/sounds/play/...

RapidoPGS 2.3.1 is now available on CRAN 🥳 (cran.r-project.org/web/packages...). Changes in dependencies were making RapidoPGS multi to fail. This new version should work as expected. Test it out!

RapidoPGS: A Fast and Light Package to Compute Polygenic Risk Scores

Quickly computes polygenic scores from GWAS summary statistics of either case-control or quantitative traits without parameter tuning. Reales,G., Vigorito, E., Kelemen,M., Wallace,C. (2021) &lt;<a hre...

cran.r-project.org

Here we are, looking forward to 2 days of exciting Genomics! If you're at the event and in need of a Bioinformatician, I'm open for new positions! 😁

Hello, world!