Brian Krueger, PhD
@h2so4hurts.bsky.social
Scientific strategist | Storyteller | Genomics, Lab diagnostic and high throughput automation | Coder | Comments are my own | Omic.ly
DNA is coded by 4 bases, but no one said that's how we have to sequence it. Ready to have your mind bent? 🧬 🧪
Fuzzy Sequencing: Sometimes close enough is good enough
DNA is coded by 4 bases, but no one said that's how we have to sequence it. Ready to have your mind bent?
omic.ly
Having trouble sleeping? A new mutation has been discovered that allows people to feel well rested after as little as 4hrs of sleep! 🧬 🧪 www.omic.ly/a-gene-for-s...
A gene for short sleep duration
Having trouble sleeping? A new mutation has been discovered that allows people to feel well rested after as little as 4hrs of sleep!
omic.ly
The most famous photo in the history of genetics wasn’t generated by Watson and Crick, but that didn’t stop them from using it to solve the structure of DNA. 🧬 🧪 #histSci www.omic.ly/the-most-fam...
The most famous picture in the history of genetics
The most famous photo in the history of genetics wasn’t generated by Watson and Crick, but that didn’t stop them from using it to solve the structure of DNA.
omic.ly
Mass Spec is leading the charge in bringing high-throughput proteomics to a lab near you. 🧬 🧪 www.omic.ly/mass-spec-is...
Mass spec is primed to lead the next proteomics revolution
Mass Spec is leading the charge in bringing high-throughput proteomics to a lab near you.
omic.ly
There’s more to de novo mutations (DNMs) than just SNPs and indels. 🧬 🧪 www.omic.ly/de-novo-muta...
De novo mutations are more common than we previously thought
There’s more to de novo mutations (DNMs) than just SNPs and indels.
omic.ly
Multiplex aptamer/antibody arrays are a gateway drug to get genetics people to embrace proteomics. 🧬 🧪 www.omic.ly/how-to-do-pr...
How to do proteomics using a high throughput sequencer
Multiplex aptamer/antibody arrays are a gateway drug to get genetics people to embrace proteomics.
omic.ly
Approximately 2,000 people die every year waiting for a liver transplant. Pigs might help change that! 🧬 🧪 www.omic.ly/a-pig-liver-...
A pig liver makes its way into a human
Approximately 2,000 people die every year waiting for a liver transplant. Pigs might help change that!
omic.ly
High throughput proteomics could revolutionize our understanding of human disease, but it's going to take some major innovations to get us there! 🧬 🧪 www.omic.ly/the-future-o...
The future of high throughput proteomics is unfolding right in front of us
High throughput proteomics could revolutionize our understanding of human disease, but it's going to take some major innovations to get us there!
omic.ly
Ultima Genomics is put to the test in MRD 🧬 🧪 www.omic.ly/will-ultimas...
Will Ultima's ultra cheap bases be a major boon to MRD?
Ultima Genomics is put to the test in MRD
omic.ly
Derek Lowe telling it like it is: No, AI isn't going to cure all disease www.science.org/content/blog...
The End of Disease
science.org
In 1994, an obscure jellyfish protein was stuck into a worm. It has enlightened biology and medicine ever since. 🧬 🧪 #HistSci www.omic.ly/jelly-fish-p...
Jelly fish proteins started brightening up microscopy in 1994
In 1994, an obscure jellyfish protein was stuck into a worm. It has enlightened biology and medicine ever since.
omic.ly
I made a feed for all things Omics! Have your posts included in it by adding a 🧬plus any additional omics related emoji🧪🧫🔬🖥️💉🦠🥼. Anything Genomics, Epigenomics, Transcriptomics, Proteomics, Metabolomics, or Metagenomics related (or adjacent!) is welcome! bsky.app/profile/h2so...
The importance of taking out the trash: An overview of cellular protein degradation pathways. 🧬 🧪 www.omic.ly/the-proteaso...
The proteasome and lysosome decide what proteins live or die
The importance of taking out the trash: An overview of cellular protein degradation pathways.
omic.ly
HOT TAKE: Dire wolves are still very much extinct, Illumina is dumping its smallest sequencer, and PacBio finally sees the light www.omic.ly/de-extincted...
De-extincted" Dire Wolves, A Discontinued Sequencer, and PacBio Goes Long
HOT TAKE: Dire wolves are still very much extinct, Illumina is dumping its smallest sequencer, and PacBio finally sees the light
omic.ly
Deep brain structures play a key role in filtering out what we perceive 🧬 🧪 www.omic.ly/how-does-the...
How does the brain control perception of everything around us?
Deep brain structures play a key role in filtering out what we perceive
omic.ly
Maybe we should just learn to not believe tech bros when they pretend to know science? cen.acs.org/biological-c...
Dire wolf debate raises concerns on scientific overhype
Even de-extinction advocates say that Colossal Biosciences’ claims are misleading
cen.acs.org
The Lac Operon showed us that gene expression can be regulated 🧬 🧪 #histsci
The Lac Operon showed us that gene expression can be regulated
'If gene expression determines the function of a cell, it must be important to control that process?' Yes, very! Let me tell you about the PaJaMo experiment.
omic.ly
Translating the Proteome: There’s more to making proteins than just transcribing DNA into mRNA. 🧬 🧪
Translation complicates the proteome, big time!
Translating the Proteome: There’s more to making proteins than just transcribing DNA into mRNA.
omic.ly
In a development that should surprise no one, population scale exome screening finds actionable variants. 🧬 🧪
Sequencing exomes in healthy populations pays dividends
In a development that should surprise no one, population scale exome screening finds actionable variants.
omic.ly
Oh, good, maybe journalism isn't dead afterall. www.newscientist.com/article/2475...
No, the dire wolf has not been brought back from extinction
Colossal Biosciences claims three pups born recently are dire wolves, but they are actually grey wolves with genetic edits intended to make them resemble the lost species
newscientist.com
Horseshoe crab blood is our first line of defense against endotoxin contamination of surgical tools and medical devices. Seriously. 🧬 🧪
Horseshoe crab blood to the rescue!
Horseshoe crab blood is our first line of defense against endotoxin contamination of surgical tools and medical devices. Seriously.
omic.ly
Proteoforms: This is where things start to get complicated. 🧬 🧪
Proteoforms make proteomics infinitely more complicated than genomics
Proteoforms: This is where things start to get complicated.
omic.ly
Brain storming about nanopore based protein sequencing generates new hypotheses to test 🧬 🧪
Will nanopores enable single molecule protein sequencers?
Brain storming about nanopore based protein sequencing generates new hypotheses to test
omic.ly
While chromosomes are usually depicted as X's, they actually spend most of their time jumbled up like a giant ball of yarn. #HistSci 🧬 🧪
Hi-C showed us that the genome has topology
While chromosomes are usually depicted as X's, they actually spend most of their time jumbled up like a giant ball of yarn.
omic.ly
The Proteome: we can’t live without it, but, what actually is it? 🧬 🧪
The proteome is so hot right now
The Proteome: we can’t live without it, but, what actually is it?
omic.ly
Clinical evidence is still desperately needed to justify the high cost of liquid biopsy based screening tests (Premium Content)
Liquid Biopsies, are we just faking it until we make it?
HOT TAKE: Clinical evidence is still desperately needed to justify the high cost of liquid biopsy based screening tests
omic.ly
The quest to find better tolerated weight loss drugs is well on its way and computational drug discovery has already identified at least one promising candidate! 🧬 🧪
In silico identification of a side effect free weight loss peptide
The quest to find better tolerated weight loss drugs is well on its way and computational drug discovery has already identified at least one promising candidate!
omic.ly