Organoid researchers!! Save the date for the annual "Organoids are Us"-symposium. Held at the Beatrix Theater in the center of beautiful historic Utrecht. Venue is a 20 minute train ride from Schiphol Airport Amsterdam. Program will follow shortly.

Short write-up of our journey. Searching for T cell transcription factors, Marc v/d Wetering stumbled across Wnt signaling. Vladja Korinek linked Wnt to colon cancer and crypt biology. Nick Barker discovered the gut stem cell. Toshi Sato invented organoids authors.elsevier.com/a/1n3No6tu0C...

Using fluorescence live imaging and an in vitro implantation model, we show that human embryo attachment begins with direct cell fusion via syncytin-2–MFSD2A interaction. With @hansclevers.bsky.social. Great work by @tnoordzij.bsky.social & @martinacelotti.bsky.social www.biorxiv.org/content/10.6...

1/11 In @science.org: A new perspective on how our intestines renew. Cells are not “pushed out” by crowding or die from apoptosis. Instead, cells play a mechanical tug-of-war, where weaker cells extrude, reframing gut renewal as force-regulated. www.science.org/doi/10.1126/...

Epithelial tension controls intestinal cell extrusion

Cell extrusion is essential for homeostatic self-renewal of the intestinal epithelium. Extrusion is thought to be triggered by crowding-induced compression of cells at the intestinal villus tip. In th...

science.org

Brain diseases are tough to treat because of the blood-brain barrier. For decades, it stumped drug delivery. At Roche pRED, we challenged that! Our Brainshuttle™ technology safely transports drugs across, opening new doors for CNS therapies. Learn more: www.roche.com/stories/clev...

Roche | Clever delivery

Brainshuttle™ technology by Roche enables effective medicine delivery across the blood-brain barrier, revolutionising CNS disease treatment and patient care.

roche.com

Exciting #organoids meeting in Glasgow, just after the summer!

🔬 Developing next-generation Antibiotics: @Roche we are pioneering the discovery and development of novel antibiotics that can fight resistant bacteria, aiming for future generations to have effective treatments. Visit our #AMR hub:https://www.roche.com/stories/antibiotics

@NatureMedicine invited me to reflect on leading research in academia vs. industry. In the end, all -academia, biotech & pharma- is needed to translate scientific breakthroughs into scalable treatments. rdcu.be/elPt8 @_hubrecht @Roche

Parallel worlds in pharma and academia

Nature Medicine - Pharma and academia require different ways of working and speaking, but teamwork always wins.

rdcu.be

Snake venom gland organoids. Study by Yorick Post and collaborators. www.sciencedirect.com/science/arti... Image credit: Anne Rios

a human liver organoid

#Lgr5+ gut #stemcells don't divide asymmetrically. They simple divide and then compete for space: This is called neutral competition. Stem cell numbers are set by the available space between the #Panethcells. Paper: Hugo Snippert et al. Cell (2010). www.cell.com/action/showP...

📢Roche's Institute of Human Biology seeks 2 visionary scientific leaders: Head of Computational Biology & Head of Exploratory Biology. Drive pioneering research, shape scientific strategy and lead innovation at the crossroad of academia and industry!🔗https://go.roche.com/ls0un #organoids #TeamIHB

Ik was in Basel voor een interview met @hansclevers.bsky.social “Het is een proces van eindeloze een-tweetjes. En bij de start van de eerste fase van het klinisch onderzoek moet je al in je hoofd hebben wat voor patiëntengroep je over zes jaar wilt behandelen.” www.newscientist.nl/blogs/een-me...

‘Een medicijn ontwikkelen is een proces van eindeloze een-tweetjes’

‘Medicijnen ontwikkelen bij Roche is schaken in een matrix van twaalf dimensies’, zegt Hans Clevers, hoogleraar moleculaire genetica.

newscientist.nl

Exciting study by Amanda Andersson Rolf et al: In vitro expansion of a human fetal #pancreas #stemcell that generates all three pancreatic cell lineages”. www.cell.com/cell/fulltex... New #organoid protocol allows the seemingly indefinite expansion of human fetal pancreatic Lgr5+ stem cell 1/

Long-term in vitro expansion of a human fetal pancreas stem cell that generates all three pancreatic cell lineages

Identification of an LGR5 as a marker for a tripotent stem/progenitor cell of the human fetal pancreas. Organoids derived from single LGR5+ cells are capable of long-term expansion in vitro and genera...

cell.com

trying out to post an animation: #organoids in #Matrigel dome

Excited to join BlueSky! Will share insights in #intestine #stemcells #cancer #organoids #drugdevelopment and others. Blue image credentials: Luminal surface of the small intestine, Anne Rios. Goblet cells red, enterocytes blue