ASCB Announces 2026 Honorific Award Winners - ASCB

Each year, the American Society for Cell Biology honors exceptional scientists whose research, mentorship, and leadership are shaping the future of cell biology. From groundbreaking discoveries to tir...

ascb.org

An AI-enabled structural atlas decodes kinase specificity across the human proteome - Nature Biotechnology

Phosphorylation potential and kinase specificity are assigned for the entire human proteome.

nature.com

Structural Mechanisms of DNAJC13 Dimeric Assembly and InsP6 binding in Recycling Endosome Regulation

The balance of plasma membrane protein degradation and recycling during endocytosis is regulated, in part, by the large J-domain-containing protein DNAJC13/RME-8 and WASH complexes, which function tog...

biorxiv.org

A CDK1 phospho-switch reprograms TRAIP to unload replisomes in mitosis

Cells entering mitosis with incompletely replicated DNA face catastrophic chromosome segregation failure. During interphase, the replisome-associated E3 ubiquitin ligase TRAIP ubiquitylates barriers i...

science.org

Pew Announces 21 New Biomedical Scholars

The Pew Charitable Trusts today announced the 21 researchers joining the Pew Scholars Program in the Biomedical Sciences. These early-career scientists will receive four years of funding to explore cu...

pew.org

biorxiv.org

Membrane bridges and nanodomain partitioning govern membrane protein targeting to lipid droplets - Nature Cell Biology

Mizrak et al. use single-molecule tracking to dissect mechanisms of protein targeting to lipid droplets. They show that nanodomain-based confinement drives selective protein accumulation on lipid drop...

nature.com

National Academy of Sciences Elects Members and International Members - NAS

WASHINGTON — The National Academy of Sciences announced today the election of 120 members and 25 international members in recognition of their distinguished and continuing achievements in original res...

nasonline.org

Giant DNA viruses encode a hallmark translation initiation complex of eukaryotic life

In contrast to living organisms, viruses were long thought to lack protein synthesis machinery and instead depend on host factors to translate viral t…

sciencedirect.com

Cancer, communication and connecting continents – People – EMBO

An interview with David Pellman, EMBO Associate Member at Harvard Medical School and the Dana-Farber Cancer Institute in Boston, MA, US

embo.org

biorxiv.org

Vagal blood volume receptors compensate for haemorrhage and posture change - Nature

A vagal reflex to blood volume changes in the heart involves PIEZO2 and helps to stabilize blood pressure in an upright posture and after blood loss.

nature.com

The Mark Foundation for Cancer Research Announces 2026 Emerging Leader Awards, Committing $3.75 Million to Next-Generation Oncology Breakthroughs | The Mark Foundation for Cancer Research

The Mark Foundation for Cancer Research is proud to announce the recipients of the 2026 Emerging Leader Awards (ELA), recognizing five visionary early-career scientists poised to make significant impa...

themarkfoundation.org

Giant DNA viruses encode a hallmark translation initiation complex of eukaryotic life

In contrast to living organisms, viruses were long thought to lack protein synthesis machinery and instead depend on host factors to translate viral transcripts. Here, we discover that giant DNA virus...

biorxiv.org

Requirements for establishment and epigenetic stability of mammalian heterochromatin

Tatarakis et al. study how H3K9me3 heterochromatin is formed and inherited in mammalian cells. Using a synthetic heterochromatin assembly system and genetic screens, they uncover requirements for init...

cell.com

Covariation MS uncovers a protein that controls cysteine catabolism - Nature

A mass spectrometry-based approach globally identifies protein regulators of metabolism and reveals the role of LRRC58 in controlling cysteine catabolism.

nature.com

ScienceDirect.com | Science, health and medical journals, full text articles and books.

authors.elsevier.com

Structure and function of IWS1 in transcription elongation

Transcription elongation by RNA polymerase II is a tightly regulated process that requires coordinated interactions between elongation factors. IWS1 (Interacts with SPT6) has been implicated as a core...

biorxiv.org

Structure of the TXNL1-bound proteasome - Nature Structural & Molecular Biology

Gao, Nardone et al. report the cryo-EM structure of human TXNL1 bound to the proteasome and reveal interactions required for the stress-induced degradation of TXNL1, an abundant protein that may regul...

nature.com

“Revolutionary Science Comes from Unexpected Angles”

magazine.hms.harvard.edu

“I Think the Entire Future of the United States Is at Stake”

magazine.hms.harvard.edu

Outstanding life scientists elected to the EMBO Membership – Press releases – EMBO

Sixty-nine new members join the community of leading life scientists in Europe and beyond

embo.org

A host organelle integrates stolen chloroplasts for animal photosynthesis

Eukaryotic life evolved over a billion years ago when ancient cells engulfed and integrated prokaryotes to become modern mitochondria and chloroplasts…

sciencedirect.com

Structural basis for the midnolin-proteasome pathway and its role in suppressing myeloma

Nardone et al. elucidate the mechanism of the midnolin-proteasome pathway, showing how midnolin achieves nuclear substrate selection and how established proteasomal components are repurposed to enable...

cell.com

The 2025 Freeman Hrabowski Scholars | HHMI

Freeman Hrabowski Scholars are outstanding early career faculty who have the potential to become leaders in their research fields.

hhmi.org

DMXL1 promotes recruitment of V1-ATPase to lysosomes upon TRPML1 activation - Nature Structural & Molecular Biology

Lee et al. show that DMXL1, a regulator of V-ATPase assembly, is recruited to lysosomes upon TRPML1 activation in a manner dependent on conjugation of ATG8 proteins on lysosomal membranes (CASM) and p...

nature.com

hms.harvard.edu

EndoMAP.v1 charts the structural landscape of human early endosome complexes - Nature

A study presents EndoMAP.v1, a resource that combines information on protein interactions and crosslink-supported structural predictions to map the interaction landscape of early endosomes.

nature.com