Deciding between HCR™ Gold or HCR™ Pro? HCR™ Gold delivers quantitative, multiplexed fluorescent imaging of up to 10 RNA and/or protein targets. HCR™ Pro supports ultra-sensitive, protease-free detection with fluorescent or chromogenic readouts. Explore here: www.molecularinstruments.com/shop

HCR™ Gold IF supports multiplexed protein detection across manual and automated workflows, so researchers can choose the setup that best fits their needs. Configure your manual HCR™ Gold IF kit: tinyurl.com/5n7dbher Interested in automated workflows? Contact us at info@molecularinstruments.com.

Thank you to everyone who spent time with us at SDB! It was a pleasure hearing about the developmental systems you’re working with and how #HCRtechnology supports your research. If we missed you at SDB, reach out to us at info@molecularinstruments.com. We’d be happy to connect!

Headed to SDB? This year, we’ll be joined by Leica Biosystems to talk about bringing HCR™ assays onto the automated BOND RX research stainer for less hands-on staining and a faster path from signal to interpretation. Stop by Booth #5 to connect with the MI and LBS teams! 📅 July 23–26

On World Brain Day, we recognize the scientists, clinicians, and research teams working to better understand the brain. Their discoveries continue to shape what we know about neural development, function, and disease. We’re proud to support the people and research moving neuroscience forward.

There’s still time to enter the Best-in-Suit: HCR™ Image Contest! This submission from Maria Jesús Vásquez Ramírez (Universidad Mayor) shows HCR™ Gold RNA-FISH in whole-mount zebrafish, capturing a key stage of ocular neurodevelopment with clear anatomical context. Submit here: lnkd.in/gyBws_yY

What can HCR™ imaging reveal about embryonic kidney development? In this webinar clip, the Miller Lab shares how they use Xenopus laevis to map gene expression to nephron segments and study kidney development. Watch: tinyurl.com/2ps48ats

SDB is one of our favorite places to catch up with the dev bio community, and it’s always fun to see how #HCRtechnology is being used across both model and non-model organisms. We’d love to hear what you’re working on and chat about how the HCR™ platform might fit! 📅 July 23–26 📍 Booth #5

HCR™ Gold IF is on the Leica Bio BOND RX research staining instrument! This workflow supports: • Compatibility with existing primaries • Parallel amplification of same-species primaries • Efficient, reproducible multiplex workflows To get started, reach out to info@molecularinstruments.com.

HCR™ HiFi Probes support high-fidelity detection of short targets, including miRNAs and siRNAs, in both manual and automated workflows. Shown here is let-7a-5p, a conserved tumor-suppressive miRNA that regulates cell differentiation and oncogenic pathways. Order today: tinyurl.com/4thytcry

Some images are hard to forget. This is your chance to share them! We’re looking for standout submissions that capture the detail, color, and character of HCR™ technology in action. If you’ve generated an image you keep coming back to, we'd love to see it. 📥Submit your image here: lnkd.in/gyBws_yY

HCR™ Gold IF is now available on the BOND RX research staining platform! Together, we’re making multiplex IF more accessible through automated workflows designed for efficiency, flexibility, and high-quality results. 🔗 Press release: tinyurl.com/uxjebewp 🔗 Brochure: tinyurl.com/4r8u5xm2

HCR™ HiFi Probes now support short target detection in manual workflows. Built with next-generation probe design, they deliver stronger on-target signal and background-suppressed performance for targets like microRNAs and siRNAs. Learn more: info@molecularinstruments.com

A preprint from Martik Lab revealed a layer of Twist1 regulation during cranial neural crest development. @laracbusby.bsky.social shared, "The sensitivity of HCR™ staining allowed us to observe transcripts that would have been missed with traditional ISH staining." Read more: tinyurl.com/32r6exrn

One of the most rewarding parts of being on the road is hearing how our users are putting #HCRtechnology to work in their own labs. From the Euro Evo Devo meeting to our HCR™ Office Hours, we loved connecting with researchers exploring a wide range of questions, organisms, and applications.

Got an HCR™ image you’re proud of? 🃏The HCR™ Image Contest: Best-in-Suit is open, and we’re looking for images that capture the detail, color, and character of your work. If you have a favorite result, send it our way! 📥 Submit your entry here: lnkd.in/gyBws_yY

Multiplex IF doesn’t have to be complicated. In Ep. 3 of our HCR™ HiFi Encoder series, we walk through the protocol and show just how easy it is to encode your primary antibodies for HCR™ Gold IF. View the full walkthrough here: tinyurl.com/4mw9baen

Episode 3: How to Encode

YouTube video by Molecular Instruments

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We’re looking forward to attending Euro Evo Devo! If you’ll be there, stop by and meet Joyce Yoo and Michelle Saylor from the MI team. We’d love to hear more about your research and talk about how #HCRtechnology could support your next set of experiments. Schedule a meeting: tinyurl.com/3a9fpzdv

Curious about the HCR™ HiFi Encoder workflow or want a quick visual guide to the simple 10-minute encoding process? Our HCR™ HiFi Encoder YouTube playlist brings everything together in one place to help you get started with confidence. Check out the playlist here: tinyurl.com/yzy9prh7

HCR™ HiFi Encoder - YouTube

Explore the breakthrough technology redefining multiplex IF. This series dives into the HCR™ HiFi Encoder, a powerful, fast, and flexible tool for encoding u...

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We’re heading to the European Society for Evolutionary Developmental Biology Meeting! If you’ll be there, stop by and say hello. We’d love to hear what you’re working on and share how the HCR™ platform can support your research. 📅 June 10–12 Register here: tinyurl.com/3ekpsxyt

A study from the Cepko Lab at Harvard used #HCRimaging to map gene expression in the developing chicken retina. “HCR™ [imaging] allowed us to scale spatial validation across many genes and developmental stages with high sensitivity and consistency.” — Heer Joisher Read more: tinyurl.com/mw9vrtew

It was great to see such a strong turnout at the In Situ Hybridization and Spatial Omics Symposium at the CRUK! If you’d like to follow up on any of the topics from the session, feel free to reach out to us at info@molecularinstruments.com. We’d be happy to continue the conversation!

We’re excited to be a part of the In Situ Hybridization and Spatial Omics Symposium at the Cancer Research UK Cambridge Institute! 🗓️ Wednesday (May 20) at 11:10 AM 📍 Lecture Theatre, CRUK Register here: tinyurl.com/5yc39x5f

We’ve got another exciting webinar for you! Our webinar with the Miller Lab is now on demand. Join Rachel Miller and Adrian Romero Mora as they explore how genetic variants can disrupt kidney development and contribute to congenital kidney diseases. Watch the recording here: youtu.be/czqh3VsYopI

Spatial Mapping of Kidney Development and Disease Mechanisms in Xenopus laevis | Webinar

YouTube video by Molecular Instruments

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Don’t miss your chance to stand out in the HCR™ Image Contest: Best-In-Suit! We’re looking for images that showcase the precision, originality, and real-world impact of your work. 📥 Submit your entry here: lnkd.in/gyBws_yY

Our webinar on Enabling Precision Medicine in Dermatology: A Clinically Validated LDT Powered by HCR™ Pro with Dr. William Damsky from Yale New Haven Hospital is now available to watch on demand. Watch the full recording here: youtu.be/gPyPR0p917s

Enabling Precision Medicine in Dermatology: A Clinically Validated LDT Powered by HCR™ Pro | Webinar

YouTube video by Molecular Instruments

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It was a pleasure meeting everyone who joined us for yesterday’s Lunch and Learn at Northwestern University! We always appreciate the opportunity to connect with the academic community. Interested in hosting a Lunch and Learn with MI? Feel free to reach out to us at info@molecularinstruments.com.

We’re excited to share that MI will be attending the Indica Labs HALO® User Group Meeting! If you’re in the Boston area, we would love to connect. Our team will be on-site to answer any questions you may have about adding #HCRtechnology to your workflows. 🗓️ May 12th 📍Le Méridien Boston Cambridge

We're excited to be working with Empire Genomics, a Biocare Medical company, to bring HCR™ Pro RNA-ISH kits to the NeoPATH Pro automated staining platform. Together, this creates a faster, more scalable path for labs looking to expand RNA-ISH workflows in tissue-based research.

Our final #MIatAACR recap features a poster created with Hamamatsu on 9-plex spatial co-detection of clinically relevant protein and RNA targets in FFPE tumors. Thank you to everyone who stopped by our poster sessions at #AACR2026! View all of our posters here: tinyurl.com/5w9yc6wc