Leanne Holt
@holtlm90.bsky.social
Assistant Professor in the Center for Substance Abuse Research at LKSOM Temple University 👩🔬 | Astrocytes are awesome 🌠🧠 | Dogs are the best 🐶
Really excited to share this review article written with @olsenlab-vt.bsky.social! We highlight that astrocytes exhibit the same activity-dependent plasticity mechanisms as neurons across learning and memory www.sciencedirect.com/science/arti...
Cellular and molecular mechanisms of astrocyte plasticity in learning and memory
Learning and memory arise from coordinated activity-dependent plasticity across neural circuits and brain regions. Astrocytes are increasingly recogni…
sciencedirect.com
Thrilled to wrap up the year and my postdoc work in the Nester lab with this publication 🥳! We show that astrocytic CREB regulates astrocyte calcium and D1-MSN activity to drive behavioral response to cocaine. pubmed.ncbi.nlm.nih.gov/41406210/
Repair after CNS injury is not strictly local! We find that lesion-remote #astrocytes (LRAs) exhibit striking spatiotemporal heterogeneity across spared regions of the injured spinal cord and shape neural repair far from the injury epicenter! www.nature.com/articles/s41...
Lesion-remote astrocytes govern microglia-mediated white matter repair - Nature
After spinal cord injury, lesion-remote astrocytes acquire heterogeneous, spatially restricted reactivity states that shape neuroinflammation, neural repair and neurological recovery.
nature.com
Really excited to announce that the Holt lab will be starting in January 2026 in the Center for Substance Use Research at Temple University Lewis Katz School of Medicine. Interested in the role of gene regulation, astrocytes, and addiction? I'm hiring at all positions-DM or email me! l-holt-lab.com
