IBC2
@ibc2-gu.bsky.social
This is the Institute of Biochemistry II at Goethe University Frankfurt, Germany. Our research focuses on cellular #signaling, #ubiquitin, #autophagy, #pexophagy, #ER-phagy, #TPD, #degraders, #molecularglues, #proteomics, #CRISPR, #cancer, #infection.
We introduce #ProxiCapture, an affinity-proteomics platform to map degrader-induced interactions in native cell & tissue lysates. We uncover a context-dependent “glueable” proteome and a scalable route to accelerate molecular glue discovery 🤗 @ibc2-gu.bsky.social @goetheuni.bsky.social
bioRxiv Cancer Bio@biorxiv-cancer.bsky.social · 7mo agoProxiCapture Reveals Context-Dependent CRBN Interactore Landscape of Molecular Glue Degraders https://www.biorxiv.org/content/10.64898/2026.01.05.697692v1
Raymond Deshaies @caltech.edu is biochemist & cell biologist, his work is highly relevant for the development of innovative pharmaceuticals. In 2025, he will assume the Friedrich Merz Visiting Fellowship. Read more about Prof. Deshaies in the #UniReport 🔗 aktuelles.uni-frankfurt.de/english/heal...
Healing Cancer through Targeted Protein Degradation | Aktuelles aus der Goethe-Universität Frankfurt
Prof. Dr. Raymond Deshaies from the California Institute of Technology (U.S.A.) will assume the Friedrich Merz Visiting Fellowship in 2025. Raymond Deshaies is a biochemist and cell biologist known fo...
aktuelles.uni-frankfurt.de
So proud of this work by #rukmini mukherjee on intersection of Cell Biology and Microbiology
The EMBO Journal@embojournal.org · last yr.Autophagy-lysosome pathways are known targets of intracellular bacteria – Ivan Đikić @idikic.bsky.social et al find Legionella uses phosphoribosyl-ubiquitination via SidE to alter autophagic SNAREs & create a bacteria-containing vacuole unable to fuse with lysosomes www.embopress.org/doi/full/10....
Check out our latest paper: #Legionella SidE effectors phosphoribosyl-ubiquitinate SNAREs STX17 & SNAP29, stalling #autophagy and fueling bacterial growth. Dive into how pathogens hijack #ubiquitin driven autophagy @embojournal.org @ibc2-gu.bsky.social @idikic.bsky.social doi.org/10.1038/s443...
Phosphoribosyl ubiquitination of SNARE proteins regulates autophagy during Legionella infection | The EMBO Journal
imageimageAmong the hundreds of proteins that are secreted by Legionella pneumophila (the causative agent of Legionnaires’ disease) during infection, the SidE class of effectors modify host proteins b...
doi.org
🚀 An inspiring milestone worth sharing! 🎥 Yesterday marked the official kick-off event for the 2nd phase of our BMBF-funded #Cluster4Future @proxidrugs.bsky.social. Thanks to all scientists, stakeholders, citizens & schools for actively participating and making it a very special day for us!
Getting ready for day 3 of #FCQC2025! Excited to learn what is new in the fields of “Proteinopathies & neurodegeneration” and “Emerging therapeutics”. @enablefrankfurt.bsky.social @ibc2-gu.bsky.social @proxidrugs.bsky.social
🤩 2nd day of #FCQC2025 conference in Frankfurt was filled with inspiring lectures, vibrant discussions, great posters and a lot of joy of meeting colleagues from all over the world! A huge thanks to all organizers & supporters! @goetheuni.bsky.social @sfb1177.bsky.social @proxidrugs.bsky.social
After an inspiring first day, we’re excited to dive into the second day of #FCQC2025 filled with amazing talks on „Organelles in biology and disease“ and „RNA and protein quality control“. @enablefrankfurt.bsky.social @proxidrugs.bsky.social @ibc2-gu.bsky.social @dfg.de
Great kick off of our #FCQC2025! Looking forward to the next days full of inspiring sessions, meaningful conversations, and exciting new connections 🙌 @sfb1177.bsky.social @enablefrankfurt.bsky.social @proxidrugs.bsky.social @goetheuni.bsky.social
What a timing! We just heard about this amazing story a moment ago at the #FCQC2025, and we can already dig further and read the paper! 😁 Congratulations, Leo and team! #ubiquitin #proteasome
Leo Kiss@leokiss.bsky.social · last yr.Super excited to share our latest work on deciphering the #Ubiquitin Code “𝗨𝗯𝗶𝗥𝗘𝗔𝗗 𝗱𝗲𝗰𝗶𝗽𝗵𝗲𝗿𝘀 𝗽𝗿𝗼𝘁𝗲𝗮𝘀𝗼𝗺𝗮𝗹 𝗱𝗲𝗴𝗿𝗮𝗱𝗮𝘁𝗶𝗼𝗻 𝗰𝗼𝗱𝗲 𝗼𝗳 𝗵𝗼𝗺𝗼𝘁𝘆𝗽𝗶𝗰 𝗮𝗻𝗱 𝗯𝗿𝗮𝗻𝗰𝗵𝗲𝗱 𝗞48 𝗮𝗻𝗱 𝗞63 𝘂𝗯𝗶𝗾𝘂𝗶𝘁𝗶𝗻 𝗰𝗵𝗮𝗶𝗻𝘀” @cp-molcell.bsky.social 1/8 www.cell.com/molecular-ce...
🚨 Save the date! 🚨 We're thrilled to announce our International Symposium on Cell & Structural Biology of Host-Pathogen Interaction 📅 Sept 10-12, 2025 📍 @cssbhamburg.bsky.social Hamburg Registration starts soon For more info: humansandmicrobes2025.de
We are pleased to introduce the 4th Frankfurt Conference on Quality Control in Life Processes organized by @idikic.bsky.social, Maike Windbergs & Volker Dötsch. The program is now available—more updates to come. fcqc.de @proxidrugs.bsky.social @enablefrankfurt.bsky.social #FCQC2025 #autophagy
‘Easy to handle’ Cereblon – a new tool for drug discovery and molecular glue screening 👍 www.sciencedirect.com/science/arti... Congrats to the Đikić lab and Merck KGaA, in collaboration with Enamine Ltd, the Nowak Lab, the Langer Lab and iBET 😀 #CRBN #TPD #PROTAC
An impressive display of technologies was used to discover how cryptic #splicing causes #celldeath and leads to development of human #diseases. www.science.org/doi/10.1126/... It was a real joy to work together with @prieto-garcia.bsky.social and all other collaborators. Many thx 👍😀
Cristian Prieto-Garcia@prieto-garcia.bsky.social · 2y agoIt is finally out! My first Science paper is online and it does not seem real😃. I am Incredibly happy! Really thanks to all my coauthors and special mention to my incredible supervisor Ivan Dikic for all the support and trust ! 🫶. #RNA #Proteostasis #ubiquitin #autophagy #RP doi.org/10.1126/scie...
Happy to join Bluesky! Please connect @idikic.bsky.social @manuelkaulich.bsky.social @prieto-garcia.bsky.social @hartungingo.bsky.social@diefenbacherlab.bsky.social
