The forces that shape cells, tissues – and medicine: How #mechanobiology has evolved👇🏽 www.linkedin.com/posts/eth-d-...

The forces that shape cells, tissues – and medicine | ETH-Department of Biosystems Science and Engineering (D-BSSE)

Researchers from D-BSSE, institutions in Basel and their international collaborators show how #mechanobiology is evolving – from studying individual molecules to understanding complex cellular systems...

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Thrilled to see our #DCM paper out in @cp-newton.bsky.social! 🎉 How do cells self-organize into complex patterns so quickly during development? We show that #directed #cell #migration — chemotaxis, durotaxis, differential adhesion — is a surprisingly fast & versatile patterning engine. 🧵👇

Newton@cp-newton.bsky.social · 2mo ago

Online now: Directed cell migration is a versatile mechanism for rapid developmental pattern formation #newton #physics

🧰 New tool alert! ⚙️ #MorphoGrad, an open-source toolbox for simulating reaction–diffusion systems in 1D and 2D tissues, with cell-to-cell parameter heterogeneity & graphical user interface. No heavy coding required. Explore complex morphogen gradient models interactively. doi.org/10.1016/j.xp...

MorphoGrad: A MATLAB toolbox for simulating steady-state morphogen gradients under cell-to-cell variability

Studying morphogen gradient-based tissue patterning in silico while accounting for biological variability remains challenging. Here, we present a MATLAB-based protocol for simulating steady-state morp...

cell.com

🔬⚙️💻 Excited to share #OptiCell3D, our new image-based framework for inferring cell mechanical properties with high precision from 3D microscopy. www.biorxiv.org/content/10.6... #ComputationalBiology #CellBiology #Biophysics #OpenSource

The @ethz.ch Animal Facility featured our work on how the lung gets its energy-efficient shape and how it remodels in disease like COPD 🐭🫁 — as part of their spotlight on responsible animal research. 🧵(1/4)

What determines the sharpness of cell fate boundaries in gradient-based patterning? We quantified #transition #zone #widths (TZW) across seven progenitor domain boundaries spanning the entire dorsal-ventral axis of the developing #mouse #neural #tube. Preprint: doi.org/10.64898/202... 🧵 1/6

"Within the competition to bring this field to a new level, SimuCell3D is remarkable and will mark a clear evolution of the topic." 🥁That’s what the committee said about this #SIBRemarkableOutputs 2024 👉Discover the output: tinyurl.com/53arz2rz @iberd.bsky.social

Out now: Simulating Organogenesis in #COMSOL: Tissue Patterning with Directed Cell Migration We provide a detailed walkthrough of how to implement #DCM partial integro-differential equation models - enabling accessible simulations of tissue patterning and morphogenesis. arxiv.org/pdf/2509.08930

Online now: Morphogen gradients can convey position and time in growing tissues #newton #physics

Morphogen gradients can convey position and time in growing tissues

Morphogen gradients are known to guide spatial patterning, but can they also encode time? Vetter and Iber propose that a co-expanding morphogen source generates transient signals, allowing cells to measure time without additional molecular clocks. The Sonic Hedgehog gradient in the mouse neural tube is used to show how this mechanism can act as a timer. Opposing gradients synchronize differentiation across the tissue, providing a simple, widely applicable strategy for coordinating space and time during development.

dlvr.it

Our paper "Morphogen gradients can convey position and time in growing tissues" is now out in Newton ‪@cp-newton.bsky.social‬ Quite fitting to see this novel idea that morphogen gradients not only encode position, but can also time & synchronise development over long distances out in a new journal.

How can cells self-organize rapidly into complex patterns during development? Let’s explore a powerful and underappreciated mechanism: Directed Cell Migration (DCM). Preprint @biorxivpreprint.bsky.social : doi.org/10.1101/2025... 👇Thread 🧵(1/11)

Let me add our paper to this review of mechanical drivers of NT folding. We showed that mammalian spinal #neuraltube folding is primarily driven by #mesoderm expansion and #zippering. #Hingepoints emerge as a result of these extrinsic forces. www.pnas.org/doi/10.1073/... x.com/DagmarIber/s...

Dagmar Iber on X: "How do #embryos fold their neural plate into a closed #neuraltube? Check out our latest #mechanobiology #preprint on the mechanical basis of mammalian spinal neurulation: https://t.co/McOxom009T #development #DevBio #morphogenesis @veerle_goederen, Roman Vetter, Katie McDole https://t.co/hfczsM7Rqu" / X

How do #embryos fold their neural plate into a closed #neuraltube? Check out our latest #mechanobiology #preprint on the mechanical basis of mammalian spinal neurulation: https://t.co/McOxom009T #development #DevBio #morphogenesis @veerle_goederen, Roman Vetter, Katie McDole https://t.co/hfczsM7Rqu

x.com

epithelial mechanics fan club@epimechfc.bsky.social · last yr.

How does the 3D neural tube develop from a sheet of 2D neural epithelium? I am @wangjianxiong.bsky.social from @melaniedwhite.bsky.social. Join me, we will go through five fantastic articles to understand neural tube (NT) formation from a live and mechanical perspective.

Epithelial tissues are well-known to invade free space and stop proliferation at confluency. Do we know what regulates cell proliferation spatially and temporally? 🧵by @dedenonmathieu.bsky.social

Are you a C++ expert and interested in making 3D cell-based tissue simulations with #SimuCell3D ever more powerful? Please apply and join us as #Master student, #PhD student or #Post-Doc!! jobs.ethz.ch/job/view/JOP... jobs.ethz.ch/job/view/JOP... x.com/DagmarIber/s...

PhD Position - 3D Cell-Based Tissue Simulation Framework

jobs.ethz.ch

SimuCell3D … for simulating tissue mechanics with cell polarization. @iberd.bsky.social Dimension: 3D Software language: C++ Download: git.bsse.ethz.ch/iber/Publica... bsky.app/profile/epim...

🚀 Introducing #PINNverse — a game-changer for parameter estimation in differential equations! 🧠💡 No forward solves. Better accuracy. Robust to noise. Preprint: doi.org/10.48550/arX... #SciComm #MachineLearning #InverseProblems #PINNs

What a beautiful cover for our #mechanobiology paper "Morphometry and mechanical instability at the onset of epithelial bladder cancer": doi.org/10.1038/s415... - thx @naturephysics.bsky.social !! News & Views "Tissue wrinkles foreshadow cancer" doi.org/10.1038/s415...

🚨 We are thrilled to announce our amazing list of keynote speakers!! @PCusachs @GeorgHalder @hirashima0203.bsky.social @iberd.bsky.social @johannaivaska.bsky.social @gijsjekoenderink.bsky.social @laurentnguyen.com @renkawitzteam.bsky.social @Sixt_Lab ...

Pleased to share our latest review "Coordination of nephrogenesis with branching of the urinary collecting system, the vasculature and the nervous system" authors.elsevier.com/a/1kXJ6Fzn7S...

Thoughtful perspective by Alexander Mietke on our recent work on #bladdercancer @naturephysics.bsky.social : www.nature.com/articles/s41...

Tissue wrinkles foreshadow cancer - Nature Physics

In a cancer mouse model, wrinkling patterns in bladder-lining tissue differ from their healthy counterparts. Changes in tissue-mechanical properties that alter elastic buckling instabilities explain t...

nature.com

Dagmar Iber & CoBi@iberd.bsky.social · 2y ago

Our paper "Morphometry and mechanical instability at the onset of epithelial bladder cancer" is now out in @naturephysics.bsky.social : rdcu.be/d5rTP #BladderCancer #Cancer #Tumor #Biomechanics #Morphometry #ComputationalModeling

How does an #embryo build an energy-efficient #fractal #lung in time for the first breath at birth? 🫁 Discover the mechanical forces shaping the bronchial tree in our latest preprint: #LungDevelopment #Mechanobiology doi.org/10.1101/2025... 👇Thread 🧵(1/9)

Our paper "Morphometry and mechanical instability at the onset of epithelial bladder cancer" is now out in @naturephysics.bsky.social : rdcu.be/d5rTP #BladderCancer #Cancer #Tumor #Biomechanics #Morphometry #ComputationalModeling

Morphometry and mechanical instability at the onset of epithelial bladder cancer

Nature Physics - Carcinoma subtypes are normally linked to specific genetic alterations, but tissue mechanical changes also play a role. Now, aberrant morphologies resembling bladder carcinoma are...

rdcu.be

We are looking for a #PostDoc with experience in #BioImage Analysis @ETH in #Basel, CH. Our mission: translate image-derived insights into mechanistic models of development & disease #lightsheet #ultrasound #CT www.jobs.ethz.ch/job/view/JOP...

Post-Doc Position: Bio-Image Analysis

jobs.ethz.ch