The preparation is important- Mark Plummer nicely outlining the importance of understanding what is studied in Vit C trials Ascorbic acid is the acidic, protonated form of Vit C (used in many trials and may explain the harm 1/2 #ccrdownunder #VITACCtrial

Next up VITaCC results session (Early high-dose vitamin C in post-cardiac arrest syndrome) up next at #CCRdownunder #VITACCtrial

Congratulations to the RSI trial team #CCRdownunder

NEJM.org@nejm.org · 8mo ago

In a randomized trial involving critically ill patients undergoing intubation in EDs or ICUs, the use of ketamine for the induction of anesthesia did not lead to significantly lower in-hospital mortality than etomidate. Full trial results: nej.md/44EOlxB @criticalcarereviews.com

Next up RSI results session (Etomidate vs Ketamine for intubation) up next at #CCRdownunder #RSItrial

#ARISEAFRICAtrial is a stepped wedge cluster- this design is useful for interventions delivered at the ICU/hospital level and individual randomisation is difficult. Clusters transition from control to intervention at different times www.bmj.com/content/350/... #ccrdownunder @criticalcarereviews.com

The stepped wedge cluster randomised trial: rationale, design, analysis, and reporting

#### Summary points

bmj.com

First up on Day 2 of #CCRdownunder is #ARISEAFRICAtrial. Post your questions using the hash tags and follow the live stream here: criticalcarereviews.com @criticalcarereviews.com

Research Summary: Early use of automated closed-loop ventilation did not increase ventilator-free days at day 28 compared with protocolized conventional ventilation. #CCRdownunder ja.ma/48AgJCj

Last session of the day- ACTiVE Trial #ACTIVEtrial #ccrdownunder

Among adults undergoing cardiac surgery at high risk of bleeding and platelet transfusion, cryopreserved platelets did not meet noninferiority for controlling postoperative bleeding and were less effective than liquid-stored platelets. #CCRdownunder ja.ma/4rEC06z

Next up #ccrdownunder - #CLIPIItrial Post your questions at #ccrdownunder and #CLIPIItrial or at the livestream: criticalcarereviews.com @criticalcarereviews.com

A wonderful example of extensive PPIE in a trial, including trying to address aspects of diversity and ensure wide engagement in a complex intervention- look forward to the primary results publication pmc.ncbi.nlm.nih.gov/articles/PMC... #irehabtrial #CCRDownUnder

Remote multicomponent rehabilitation compared to standard care for survivors of critical illness after hospital discharge (iRehab): a protocol for a randomised controlled assessor-blind clinical and cost-effectiveness trial

The consequences of critical illness can be substantial and multifactorial, encompassing physical deconditioning, mental health impairments, fatigue, and declines in health-related quality of life. We hypothesise that for people discharged after ...

pmc.ncbi.nlm.nih.gov

Second at #ccrdownunder - #IREHABtrial Post your questions at #ccrdownunder and #IREHABtrial or at the livestream: criticalcarereviews.com

ImmunoSep uses a double-dummy design. What is this? It is a design to maintain blinding when 2 treatments can't be made identical- all participants receive 2 treatments- one which is active and the other which is placebo #ccrdownunder

JAMA@jama.com · 8mo ago

RCT: Among patients with #sepsis, a precision immunotherapy strategy targeting macrophage activation-like syndrome and sepsis-induced immunoparalysis improved organ dysfunction by day 9 compared to placebo.#CCRdownunder ja.ma/3MkSb95

RCT: Among patients with #sepsis, a precision immunotherapy strategy targeting macrophage activation-like syndrome and sepsis-induced immunoparalysis improved organ dysfunction by day 9 compared to placebo.#CCRdownunder ja.ma/3MkSb95

Up first at #ccrdownunder - #IMMUNOSEPtrial Post your questions at #ccrdownunder and #IMMUNOSEPtrial or at the livestream: criticalcarereviews.com

Looking forward to #ccrdownunder- if you are following along please include this hashtag in any posts and I can moderate your questions online- enjoy the live!!!

Very proud to be here as part of the TARGET PROTEIN study team and support Lee-anne Chapple, Matt Summers and Adam Deane (with Sandy Peake) #CCR25 jamanetwork.com/journals/jam...

Always a good conference to follow for innovative trial designs in the context of critical care 👇🏻 #CCR25

Marion Campbell@marionkcampbell.bsky.social · last yr.

#CCR25 … here we go! Three days of deep discussion of the top trials in critical care. If you are not in the room, do connect via livestream - see criticalcarereviews.com

Congratulations to all the sites of TARGET PROTEIN, the ANZICS CTG and all members of the management committee #CCR25

JAMA@jama.com · last yr.

Augmenting enteral protein did not improve outcomes for critically ill patients compared with standard protein levels in the intensive care setting. #CCR25 @criticalcarereviews.com https://ja.ma/4kuYRxv

Thank you to Fresenius Kabi for a fabulous #FRANCASIA25 in beautiful Taiwan. It was my privilege to be part of the speaking team and share knowledge. The combined program of ICU, oncology and surgery provides the opportunity to learn from each field Some key takeaways 1/

I am thrilled to receive an #NHMRC EL2 fellowship. I aim to use novel trial design to investigate nutrition interventions in critical illness. I also wish to acknowledge the many deserving applicants who missed out @monashuniversity.bsky.social www.monash.edu/medicine/new...

Critical care, climate health and stronger health services to be the focus of Investigator Grant successes

Improvements to acute and critical care medicine, tackling the health impacts of climate change, and driving more equitable, sustainable health services will be a major focus for researchers in our Sc...

monash.edu

Hi all!! I have recently come across from X (@ICUnutrition)- I am an A/Prof and Critical Care Dietitian- you can see more about my work here: www.monash.edu/medicine/sph... Follow along if you want to receive my updates!