The Border She Couldn't Cross | IDHub Case

Choosing malaria chemoprophylaxis when the patient is pregnant and the itinerary hits a resistance border. Featuring Plasmodium falciparum, Plasmodium vivax, Plasmodium ovale. Interactive infectious d...

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The Shield Down the Drain | IDHub Case

Invasive pneumococcal disease as the first clue to an acquired immunodeficiency. Featuring Streptococcus pneumoniae. Interactive infectious diseases case from IDHub.

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The PCR That Climbed | IDHub Case

A lung transplant recipient's rising CMV viral load despite ganciclovir leads through resistance genotyping, foscarnet toxicity, and ultimately to maribavir. Featuring Cytomegalovirus, CMV. Interactiv...

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Undercooked | IDHub Case

A veterinary technician with steak tartare, two cats, and three weeks of fever and posterior cervical lymphadenopathy. Featuring Toxoplasma gondii. Interactive infectious diseases case from IDHub.

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The Negative CrAg | IDHub Case

A leukemia patient with cleared candidemia on micafungin develops meningitis with a negative cryptococcal antigen — and a sanctuary-site drug failure. Featuring Candida tropicalis, Candida. Interactiv...

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The Nerve Below the Surface | IDHub Case

Progressive foot drop and hand weakness in an immigrant with no skin lesions — and a diagnosis hiding in the nerves. Featuring Mycobacterium leprae. Interactive infectious diseases case from IDHub.

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The Vet Who Lent His Name to the Soil | HistorID

Edmond Nocard was a French veterinarian at Pasteur's institute when he isolated a branching filament from a dying cow in 1888. The genus that bears his name turned out to live in soil worldwide, cause...

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The Cytokine Storm Within | IDHub Case

Diffuse lymphadenopathy, a hyperinflammatory state, and plasmablasts in an HIV-positive patient with an enhancing retroperitoneal mass. Featuring Human herpesvirus 8, HHV-8, KSHV. Interactive infectio...

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When Mechanisms Collide | IDHub Case

Three organisms, three kingdoms, and three antibiotic mechanisms of action tested in a single case of polymicrobial bacteremia from bowel perforation. Featuring Escherichia coli, Enterococcus faecium,...

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The Delayed Flight That Found a Virus | HistorID

In 1964, Anthony Epstein, Yvonne Barr, and Bert Achong found the first human cancer virus — after a fog-diverted flight accidentally solved the cell culture problem that had stalled them for years.

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The Bite You Didn't Feel | IDHub Case

An Amazon traveler returns with a dengue-like illness and a vector most clinicians do not think to ask about. Featuring Oropouche virus. Interactive infectious diseases case from IDHub.

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Legs from the Bush | IDHub Case

A safari traveler returns with fever, regional nodes, and multiple eschars on the legs. Featuring Rickettsia africae. Interactive infectious diseases case from IDHub.

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The Joint Pain Before the Murmur | IDHub Case

Culture-negative endocarditis, chronic arthralgias, and PAS-positive macrophages on valve tissue. Featuring Tropheryma whipplei. Interactive infectious diseases case from IDHub.

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The Culture That Changed the Scope | IDHub Case

Subacute endocarditis caused by Streptococcus gallolyticus subsp. gallolyticus leading to discovery of colorectal neoplasia — the strongest organism-disease association in clinical infectious diseases...

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The Spindle That Broke Panama | HistorID

Fusarium means 'spindle' in Latin, named for the canoe-shaped spores of a soil fungus that destroyed the banana industry in Panama and reshaped the political economy of Central America.

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Salt and Iron | IDHub Case

Necrotizing fasciitis with hemorrhagic bullae in a fisherman with hemochromatosis after a minor saltwater laceration — curved gram-negative rods and septic shock within 48 hours. Featuring Vibrio vuln...

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The Painted Disease | HistorID

Pinta means 'painted' in Spanish. It is the name of a skin disease caused by Treponema carateum, a spirochete indistinguishable from syphilis under a microscope but radically different in what it does...

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The Eosinophils Knew | IDHub Case

Eosinophilic appendicitis caused by a nematode with pathognomonic lateral alae, discovered on pathology after appendectomy in a young woman. Featuring Enterobius vermicularis. Interactive infectious d...

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False Unit, Real Problem | HistorID

Pseudomonas means 'false unit' in Greek and 'verdigris' in Latin. Neither name captures what actually makes this bacterium dangerous: it can eat crude oil. And anything that can eat oil can eat almost...

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Contaminant | IDHub Case

A gram-positive coccobacillus dismissed as a diphtheroid contaminant in a patient with advanced HIV and a cavitary lung lesion. Featuring Rhodococcus equi. Interactive infectious diseases case from ID...

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The Parasite That Wasn't | HistorID

In 1892, a 22-year-old Argentine medical student saw a round body under his microscope and thought it was a protozoan parasite. He named it Coccidioides — 'resembles Coccidia.' He was wrong about the ...

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The Water Was Warm | IDHub Case

A previously healthy young man in Texas develops fulminant meningoencephalitis days after swimming in a warm lake, with anosmia and motile trophozoites on CSF wet mount. Featuring Naegleria fowleri. I...

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The Nodules Before the Headache | IDHub Case

A kidney transplant recipient with recent rejection therapy develops cavitary pulmonary nodules and ring-enhancing brain lesions. Featuring Aspergillus fumigatus. Interactive infectious diseases case ...

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The Little Sprinkler | HistorID

Aspergillus is Latin for 'little sprinkler.' The name was coined in 1729 by a Catholic priest who looked at a mold under his microscope and saw the holy water wand he used every morning at Mass.

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The Red Fog Over San Francisco | HistorID

In 1950, the U.S. Navy sprayed a bright red bacterium over San Francisco to see how a biological weapon would spread through a city. The military thought the microbe was harmless. Eleven people ended ...

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The Wolf in CoNS Clothing | IDHub Case

A destructive native-valve endocarditis caused by a coagulase-negative staphylococcus that should never be dismissed as a contaminant. Featuring Staphylococcus lugdunensis. Interactive infectious dise...

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When West Nile Was Just a District | HistorID

Most people assume West Nile virus is named after the Nile River. It isn't. It's named after a colonial district in northwestern Uganda — a place most of the world had never heard of until a fever in ...

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The Summer Temporal Lobe Trap | IDHub Case

A 17-year-old with summer encephalitis, temporal PLEDs, hyponatremia, and a negative routine CSF panel. Featuring La Crosse virus. Interactive infectious diseases case from IDHub.

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The Persistent Burn | IDHub Case

Persistent urethritis in a young man after standard GC/CT treatment, with questions on microbiology, NAAT methodology, and resistance-driven sequential therapy. Featuring Mycoplasma genitalium. Intera...

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How Hepatitis Got Its Letters | HistorID

Hepatitis A, B, C, D, and E sound like a natural sequence — but the alphabetical naming system was an accident of history, not a plan. It started when a British physician replaced misleading names wit...

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