Genomic epidemiology of invasive meningococcal disease in Scotland before, during, and after the COVID-19 pandemic: a retrospective observational study

The COVID-19 pandemic was associated with changes in IMD capsular distribution in Scotland, concomitant with a decline in clonal complex 11. In 2025–26, 4 years after physical restrictions eased, geno...

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Safety of biopsy in phaeochromocytoma and paraganglioma: an international, multicentre, retrospective cohort study

Percutaneous biopsy of PPGLs was associated with a low mortality rate. Serious complication rates were also low, most of which were not catecholamine-related. These findings challenge current recommen...

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Evaluation of the effect of multimorbidity on difficult-to-treat asthma using a novel score (MiDAS): a multinational study of asthma cohorts

MiDAS highlights the co-occurrence of multimorbidity with the worst outcomes in difficult-to-treat asthma. These findings strongly indicate that an airway-centric approach is inadequate and that holis...

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A Novel Breast Arterial Calcification Age-Based Percentile Nomogram for the Incremental Prediction of Incidental Cardiovascular Events:

jacc.org

World Stroke Organization (WSO) rehabilitation certification program - Jessica Nolan, Kwah Li Khim, Dorcas BC Gandhi, Jussara A Oliveira Baggio, Shamala Thilarajah, Marina Charalambous, Emily A Steven...

Background: Rehabilitation has been identified by the World Stroke Organization (WSO) as a key priority to reduce the global burden of stroke. Global access to ...

journals.sagepub.com

Whole-population trends in obesity across dimensions of inequality in England, 2019–25: a retrospective, longitudinal cohort study of 54 million adults

Obesity affects nearly one in three adults in England, with disproportionate burden among disadvantaged groups and widening disparities since the COVID-19 pandemic. Increasing rates among individuals ...

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PKCα-mediated nuclear translocation of cGAS stabilizes β-catenin and drives metastasis

Zhang et al. reveal that nuclear cGAS promotes breast cancer metastasis by stabilizing β-catenin independently of STING. PKCα-mediated phosphorylation drives cGAS nuclear entry, where it prevents TRIM...

cell.com

AI-driven clinical decision support for early diagnosis and treatment planning in patients with suspected sleep apnea using clinical and demographic data before sleep studies - npj Primary Care Respir...

npj Primary Care Respiratory Medicine - AI-driven clinical decision support for early diagnosis and treatment planning in patients with suspected sleep apnea using clinical and demographic data...

nature.com

Diagnostic tests and headache misdiagnoses in individuals with resistant and refractory migraine – data from the REFINE study - Federico De Santis, Chiara Rosignoli, Agnese Onofri, Mark Braschinsky, O...

Background Individuals with difficult-to-treat migraine, including resistant migraine (ResM) and refractory migraine (RefM), might experience treatment delays, ...

journals.sagepub.com

Clinical Manifestations, Tumor Associations, and Long-Term Outcomes of Anti-KLHL11 Encephalitis | Neurology Neuroimmunology & Neuroinflammation

Background and ObjectivesAnti–Kelch-like protein 11 (KLHL11) encephalitis was discovered in middle-aged men with testicular seminoma and rhombencephalitis, defining a new type of paraneoplastic neurol...

neurology.org

Frontiers | From metabolic substrate to epigenetic regulation: roles and mechanisms of lactylation in brain health and disease

Lactate, traditionally regarded as a metabolic byproduct of glycolysis, is now recognized as a critical signaling molecule in the central nervous system. Eme...

frontiersin.org

Garlic-derived metabolite activates LKB1, promotes adipose eNAMPT secretion, and improves age-related muscle function via hypothalamic signaling

Suzuki and Yoshioka et al. show that the garlic-derived metabolite S-1-propenyl-L-cysteine (S1PC) increases circulating eNAMPT, a key NAD+ biosynthetic enzyme, in mice and humans by activating a criti...

cell.com

DGAT-driven futile lipid cycling has a pronounced, yet concealed, thermogenic function

Through comprehensive phenotyping of complex mouse models and in vitro studies, the authors uncovered that futile lipid cycling has a sizable thermogenic output. However, in its absence, alternative m...

cell.com

Mitochondria-lysosome coupling contributes to lysosome acidification and aging

While classical models propose that lysosomes/vacuoles are acidified using free cytosolic protons, Liu et al. reveal that mitochondrial electron transport provides a substantial proton source through ...

cell.com

Therapy and biomarker dependent progression-free survival in infant sonic hedgehog medulloblastoma: a multi-national retrospective cohort study

Our findings show that iMBSHH outcomes and prognostic biomarkers are therapy dependent. In our retrospective patient group, non-metastatic iMBSHH treated with high-dose or IVT-MTX chemotherapy-only ha...

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Polyendocrine metabolic ovarian syndrome, the new name for polycystic ovary syndrome: a multistep global consensus process

Polyendocrine metabolic ovarian syndrome (PMOS), previously named polycystic ovary syndrome (PCOS), affects one in eight women. However, the term PCOS is inaccurate, implying pathological ovarian cyst...

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Association between antihypertensive treatment and hospitalisation or death due to falls according to sex, ethnicity, and social deprivation status: an observational cohort study in English primary ca...

All subgroups of patients with antihypertensive prescriptions had an increased risk of hospitalisation or death due to falls versus those who were unexposed. No significant difference in risk of falls...

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Deep learning model for pathological invasiveness prediction using smartphone-based surgical resection images in clinical stage IA lung adenocarcinoma (SuRImage): a prospective, multicentric, diagnost...

This first-in-field diagnostic study focused on intraoperative diagnosis based on surgical resection images in stage IA LUAD and provides insights into the macroscopic morphological features for patho...

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The association between 10-year cardiovascular risk and fracture incidence in postmenopausal women: a prospective analysis from the Women's Health Initiative

A higher 10-year predicted CVD risk was associated with higher MOF and hip fracture risk after adjustment for sociodemographic, lifestyle, and clinical factors. CVD risk may have implications for frac...

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Nucleoprotein and glycoprotein based serological assays for detection of Marburg virus infections

The MARV anti-NPct MR assay provides a rapid, high-throughput, species-agnostic tool expected to differentiate natural infection from vaccine-induced immunity, addressing a critical gap in the current...

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Interleukin-27 remodels the bone marrow niche to suppress B-cell development and leukaemia progression in mouse models

IL-27 constrains B-cell haematopoiesis and B-ALL progression through coordinated progenitor inhibition and BM niche remodelling, revealing a cytokine-driven strategy with the potential to enhance leuk...

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Genetics of educational resilience after adverse childhood experiences

ACEs were associated with lower educational attainment, irrespective of genetic predisposition to education. A potential novel variant, rs2743239, was linked to educational resilience specifically amo...

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Continuous glucose monitoring versus self-monitoring of blood glucose in individuals with type 2 diabetes: a randomised, multicentre, open-label, superiority trial

In adults with type 2 diabetes on basal insulin plus modern therapies, real-time CGM improved glycaemic control versus SMBG during self-management and under clinician-supported management.

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Tumor-immune-neural circuit disrupts energy homeostasis in cancer cachexia

Shi et al. delineate an interplay among tumor cells, immune cells, and the nervous system that drives cancer cachexia and anorexia. Specifically, tumor-derived CSF1 induces macrophage GDF15, which sig...

cell.com

TGFβ induces an atypical EMT to evade immune mechanosurveillance in lung adenocarcinoma dormant metastasis - Nature Cancer

Wang et al. report that LUAD cells entering dormancy transition into a TGFβ-induced atypical mesenchymal state characterized by a soft spheroidal morphology and strong EMT signature, which protects di...

nature.com

A convergent uPAR-positive tumor ecosystem creates broad vulnerability to CAR T cell therapy

Synergizing with senescence-inducing therapies, uPAR CAR T cells eradicate primary and metastatic solid tumors with minimal myelodepletion by targeting both tumor cells and the stroma in preclinical m...

cell.com

Prevalence and determinants of sacroiliac joint bone marrow oedema in the general population in Germany: a population-based cross-sectional study

Sacroiliac bone marrow oedema affects nearly one-third of adults, showing associations with pregnancy, overweight, and occupational physical stress rather than inflammatory disease. This prevalence ex...

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Kidney outcomes with GLP-1 receptor agonists in people with type 2 diabetes already receiving SGLT2 inhibitors: a target trial emulation study using UK primary care data

These real-world data suggest that the kidney-protective benefits of GLP-1 receptor agonists observed in randomised trials of individuals with type 2 diabetes might also extend to individuals already ...

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Azurocidin-1 as a mediator of bronchiectasis severity, epithelial defence, and target of dipeptidyl peptidase-1 inhibition: an international, multicohort study

AZU1 was identified as a novel marker of disease severity in bronchiectasis, associated with bacterial infection and exacerbation, and targeted by DPP1 inhibition.

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