Thrilled to see our paper on CAR-T cells and STING agonists in PDAC highlighted by @aga-gastro.bsky.social today! Very grateful to the brilliant and inspiring @v-hornung.bsky.social for his mentorship and scientific vision throughout this work. @lmu-klinikum.bsky.social @genecenter-lmu.bsky.social

@aga-gastro.bsky.social · 2w ago

Study finds that STING-deficient CAR-T cells + diABZI boost antitumor activity, increase CAR-T persistence, and improve tumor control in pancreatic cancer models, highlighting a potential new strategy for solid tumors. 🔗 https://ow.ly/JVzg50Zq3PM

I am very excited to share the second paper of my PhD published in @cp-cell.bsky.social. Many thanks to all co-authors, especially from Thomas Carell's group, and my supervisor @v-hornung.bsky.social for their great support and collaboration! www.cell.com/cell/fulltex...

Pseudouridine RNA avoids immune detection through impaired endolysosomal processing and TLR engagement

Toll-like receptors (TLRs) 7 and 8 detect RNA degradation products to sense infection. However, modified nucleosides common in self-RNA—most notably pseudouridine—evade recognition. This study finds t...

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