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Indrek Kalvet

@ikalvet.bsky.social

🇪🇪 De Novo enzyme design • HHMI Postdoc at the Institute for Protein Design at University of Washington

4 Posts246 Follower 80 Folgt

Nature Catalysis @natcatal.nature.com · 11mo ago

New online! De novo design and evolution of an artificial metathase for cytoplasmic olefin metathesis

De novo design and evolution of an artificial metathase for cytoplasmic olefin metathesis

Nature Catalysis, Published online: 03 November 2025; doi:10.1038/s41929-025-01436-0The creation of artificial metalloenzymes compatible with complex biological settings could enable broad applications. Now a de novo-designed artificial metalloenzyme containing an abiological ruthenium cofactor is reported and optimized for ring-closing metathesis in the cytoplasm of whole cells.

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Indrek Kalvet @ikalvet.bsky.social · last yr.

RFdiffusion2 is now live! github.com/RosettaCommo... You can now design proteins, and in particular enzymes from just partially defined amino acid side chains, and without defining their sequence position or order!

Indrek Kalvet @ikalvet.bsky.social · 2y ago

We are happy to share that the code and weights of PLACER (formerly known as ChemNet) are now public! This method allows for rapid evaluation of protein side chain and ligand conformational ensembles, with uses in ligand docking and enzyme evaluation. github.com/baker-labora...

GitHub - baker-laboratory/PLACER: PLACER is graph neural network for local prediction of protein-ligand conformational ensembles.

PLACER is graph neural network for local prediction of protein-ligand conformational ensembles. - baker-laboratory/PLACER

github.com