Interested in live tissue clearing? SeeDB-Live is now commercially available from Nacalai Tesque!  Product page: www.nacalai.co.jp/products/445/ Protocol: sites.google.com/site/seedbre...

Takeshi Imai@imailab.bsky.social · 5mo ago

Our live tissue clearing paper is out in @natmethods.nature.com! We achieved optical clearing of mammalian brain tissues without compromising normal neuronal function. Big congrats to Shigenori Inagaki and our wonderful collaborators! 🎉 www.nature.com/articles/s41... (1/10)

A Clear Solution: Seeing living brain cells fire signals at high magnification by matching the refractive index between tissue & lens 📹 Shigenori Inagaki et al @imailab.bsky.social, Kyushu University in @natmethods.nature.com ➡️ bpod.org.uk/archive/2026... with @rooph.bsky.social

SeeDB-Live is a tissue-clearing approach for live tissue slices or brains, improving image quality while having minimal effects on electrophysiological properties of neurons. @imailab.bsky.social www.nature.com/articles/s41...

Isotonic and minimally invasive optical clearing media for live cell imaging ex vivo and in vivo - Nature Methods

SeeDB-Live is a tissue-clearing approach for live samples such as tissue slices or the in vivo brain. It improves image quality while having minimal effects on electrophysiological properties of neuro...

nature.com

Our live tissue clearing paper is out in @natmethods.nature.com! We achieved optical clearing of mammalian brain tissues without compromising normal neuronal function. Big congrats to Shigenori Inagaki and our wonderful collaborators! 🎉 www.nature.com/articles/s41... (1/10)

Join us at TENSS 2026 to open black boxes, explain how things/brains work and debate the impact (or lack or it) of various new technologies on understanding of the brain and on society. tenss.ro Apply by: March 15th!

Our research on magneto-sensitive fluorescent proteins and some of their applications has now been published! Huge thank you to the many many people involved in making this happen. 🧪 www.nature.com/articles/s41...

Quantum spin resonance in engineered proteins for multimodal sensing - Nature

A recently developed class of magneto-sensitive fluorescent proteins are engineered to alter the properties of their response to magnetic fields and radio frequencies, enabling multimodal sensing of b...

nature.com

#ELMI2026 will take place in Coimbra, Portugal 🇵🇹from June 16-19 hosted by @ppbioimaging.bsky.social colleagues. Submit your abstracts for oral presentations by January 18! More information & registration🔽 ppbi.pt/wordpress/in...

Our new paper is out in Science Advances! We found that dendritic compartment-specific spine “formation” during adolescence is critical for cortical development. We also found that schizophrenia-related genes are important in this process. (1/6) www.science.org/doi/10.1126/...

Dendritic compartment-specific spine formation in layer 5 neurons underlies cortical circuit maturation during adolescence

Mouse models of schizophrenia show defects in adolescent spine formation in a specific dendritic compartment of L5 neurons.

science.org

In June 2001, I arrived in SFO with a suitcase, a student visa, and disproportionate dreams. My life since has been nothing but a dream. My heart is with the international students in the US today.

Our new paper is out in Science. What is the synaptic plasticity rule in the brain, we asked. It turns out there are multiple, even within individual neurons. Congrats Jake! www.science.org/doi/10.1126/...

Distinct synaptic plasticity rules operate across dendritic compartments in vivo during learning

Synaptic plasticity underlies learning by modifying specific synaptic inputs to reshape neural activity and behavior. However, the rules governing which synapses will undergo different forms of plasti...

science.org

✨New paper from my lab out now in @cp-cell.bsky.social! We identified pathways for airway protective reflexes—swallowing and coughing—in mice, driven by rare throat chemosensory cells that signal vagal nerves via channel synapses. cell.com/cell/fulltex...

If you are interested in what happens deep in the brain during puberty, please check our new paper in Neuron. We visualize how nutritional status shapes sexual maturation in female mice: A flagship study by an excellent postdoc Teppei Goto. (1/N

How does neural activity control developmental synapse elimination? Here is a new review paper from the lab: Activity-dependent synaptic competition and dendrite pruning in developing mitral cells. www.frontiersin.org/journals/neu...

A background in physics, and his own curiosity, have helped Dmitry Rinberg tackle the complexities of the neuroscience of smell. More on Rinberg sniffing out the mysteries of olfaction. By Lina Zeldovich www.thetransmitter.org/olfaction/sn...

The sympathetic nervous system may control selective organs, but how this specificity is achieved is unknown. Our new study @NatureComms www.nature.com/articles/s41...　uncovers a parallel labeled-line organization within the lower thoracic spinal cord. 1/

Parallel labeled-line organization of sympathetic outflow for selective organ regulation in mice - Nature Communications

How individual organs are specifically regulated by the sympathetic neurons at the cellular level remains not fully understood. Here, authors identify two molecularly distinct sympathetic pathways tha...

nature.com

From our recent paper: 7-color Tetbow image of the neocortex🌈 We can distinguish hundreds of neurons based on the combinatorial expression of 7 FPs. Here is the list of plasmids for Tetbow experiments if you are interested (all available from Addgene): sites.google.com/site/seedbre...

Hello, this is my first Bluesky post! We love neuroimaging🔬 Attached are covers from our lab featuring our favorite neurons, mitral cells in the olfactory bulb and L5 neurons in the neocortex. What's your #FavoriteNeuron?