Fucoidans from brown algae and diatoms drive marine carbon sequestration partly because they're hard to break down. Sichert et al. show how synergistic interactions between degraders are critical for their degradation, giving insights into ocean carbon cycling www.nature.com/articles/s41...

Synergistic degradation of fucoidans in the ocean - Nature

Efficient degradation of fucoidans depends on complementary bacterial guilds that cooperatively break backbone and side-chain sugars, revealing a conserved, globally relevant mechanism that shapes mar...

nature.com

A new perspective from IMSB's @nzamboni.bsky.social with Theodore Alexandrov. They map out how scaling up metabolomics, bridging single-cell resolution with large population cohorts, will have an impact on biology and medicine. www.nature.com/articles/s41...

Metabolomics across scales: from single cells to population studies - Nature

This Perspective reviews the potential and the challenges of metabolomics approaches, encompassing both single-cell and population-scale metabolomics.

nature.com

We are delighted to announce that Paola Picotti has been awarded the Otto Naegeli prize for biomedical research! otto-naegeli-preis.ch

Congratulations to the @imsb-eth.bsky.social founder Ruedi Aebersold, alongside @mannlab.bsky.social and John Yates. They have received the 2026 Gairdner Award for "establishing the foundations of modern systems proteomics" www.gairdner.org/resource-hub...

2026 Canada Gairdner Award Winners Announced

2026 Canada Gairdner Awards recognize world-leading scientists for breakthrough discoveries advancing human health.

gairdner.org

The Swiss Institute of Bioinformatics @sib.swiss highlights every year some outstanding outputs from SIB members. Have a look at some of the great bioinformatics research of SIB members from 2025 www.sib.swiss/news/discove...

Discover the SIB Remarkable Outputs 2025

Seven outstanding data resources, software tools, and peer-reviewed publications from our members have been recognized as SIB Remarkable Outputs – an annual spotlight on the excellence and diver...

sib.swiss

Our paper on disease mechanisms in synucleinopathies, led by Tetiana Serdiuk, is out at Molecular Systems Biology. #proteomics #structuralproteomics #neurodegeneration #Parkinsons #alphasynuclein #structuralbiology #ethz @imsb-eth.bsky.social @molsystbiol.org

In a recent issue of Cell Systems, 13 scientists provide their insights into "𝗪𝗵𝗮𝘁 𝗾𝘂𝗲𝘀𝘁𝗶𝗼𝗻𝘀 𝗰𝘂𝗿𝗿𝗲𝗻𝘁𝗹𝘆 𝗯𝗲𝘆𝗼𝗻𝗱 𝗿𝗲𝗮𝗰𝗵 𝗱𝗼 𝘆𝗼𝘂 𝗵𝗼𝗽𝗲 𝘀𝘆𝘀𝘁𝗲𝗺𝘀 𝗮𝗽𝗽𝗿𝗼𝗮𝗰𝗵𝗲𝘀 𝘄𝗶𝗹𝗹 𝗲𝗻𝗮𝗯𝗹𝗲 𝗮𝗱𝗱𝗿𝗲𝘀𝘀𝗶𝗻𝗴 𝗶𝗻 𝘁𝗵𝗲 𝗻𝗲𝘅𝘁 𝗱𝗲𝗰𝗮𝗱𝗲?", including IMSB's Paola Picotti @picottilab.bsky.social www.sciencedirect.com/science/arti...

What questions currently beyond reach do you hope systems approaches will enable addressing in the next decade?

sciencedirect.com

A new study lead by the Carvunis lab looks at the difficult challenge of studying microproteins through mass spectrometry, proposing protocols and analysis workflows for the MS-based detection of these proteins. www.nature.com/articles/s41...

We’re delighted to report a global structural proteome analysis within living cells! doi.org/10.1038/s443... #proteomics #structuralproteomics #massspectrometry #structuralbiology #ethz @imsb-eth.bsky.social

ETH Zurich@ethz.ch · last yr.

Teamwork is crucial for proteins. Little is known, however, about which protein teams are actually active in which tissues. A new large-scale study by systems biologists at ETH Zurich is now redrawing the map. ethz.ch/en/news-and-...

Berend Snijder, former Assistant Prof of or institute, will join the Botnar Institute of Immune Engineering (BIIE) a Faculty Professor and Research Group Leader. Until the move, he will remain a visitor group leader at the institute. immune.engineering/news/dr-bere...

Some words from our institute's chair Paola Picotti and from @kathrynslilley.bsky.social in celebration of Women and Girls in Science.

@eupaproteomics.bsky.social · 2y ago

Happy Women and Girls in Science Day! 🥳 Discover groundbreaking insights from @kathrynslilley.bsky.social and Paola Picotti—two remarkable leaders in sub-cellular proteomics and LiP-MS! 🎥 Watch their inspiring videos here: youtu.be/5fYcQyJPCzE?... and youtu.be/3kS6tB8WfmA?.... #February11 #Science

Fantastic work by @zampierilab.bsky.social‬ (formerly at IMSB) on studying drug mode of action using large scale metabolic profiling.

Zampieri Lab@zampierilab.bsky.social · 2y ago

We are very excited to share that the recent research from our lab has been published in Nature Biotechnology! Thanks to our lab members and our collaborators for contributing to this project and especially to Laurentz for driving this exciting research! www.nature.com/articles/s41...

The Institute of Molecular Systems Biology is happy to join Bluesky. At IMSB, we strive to develop, apply, and teach the interdisciplinary and quantitative science of systems biology. We are part of the Department of Biology of ETH Zurich.

Institute of Molecular Systems Biology

Institute of Molecular Systems Biology

imsb.ethz.ch