For our Cohort of the Week, a landmark Cell study shows biological baselines aren't fixed. Layering #antibody responses to 37 microbial antigens over deep #MultiOmics gave unique insight into how geographic exposure history drives biological aging. doi.org/10.1016/j.ce...

How does a lifetime of environmental exposures shape how we age? By adding antibody #Reactomics to plasma #Proteomics, we can map immune history to see how past infections contribute to #CellularAging and chronic disease. Potentially transformational. doi.org/10.1038/s415...

Plasma proteomic signatures of cellular aging predict human disease - Nature Medicine

The biological age of individual cell types can be evaluated using plasma proteomics, revealing diverse aging profiles across more than 40 cell types and links between the accelerated aging of specifi...

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A landmark study in Cell tracks proteomic signals to predict lung cancer 5+ years early. Want the full picture? Adding Infinity Bio’s antibody reactomics uncovers the precise infectious & environmental triggers contributing to the inflammatory response tracked by proteomics analysis.

New research in Cell Reports Medicine identifies specific gut species linked to Type 2 Diabetes risk. But an important question remains: does the host's immune response actively prevent or allow this microbial colonization? doi.org/10.1016/j.xc... Antibody reactomics can help solve this mystery.

By mapping proteomes across 5 major cohorts, a new Nature Aging study shows how APOE2 & APOE4 shape Alzheimer’s through entirely different pathways. Multi-omic profiling is unlocking hidden disease mechanisms. What omic layers are your cohort missing? rdcu.be/fkVs9

A landmark study on the new HHGP-HK Asian cohort revealed that standard health scores like PhenoAge fall short outside European populations. Large, diverse cohorts are critical to uncovering true global disease associations and validating biomarkers for everyone. #PrecisionMedicine

Large, diverse cohorts are vital for #PrecisionMedicine. "Matching" gut #Microbiome fingerprints across 674 geographical diverse #Melanoma patients creates accurate treatment outcome predictions. These microbial markers provide a durable benchmark for #Immunotherapy success. doi.org/10.1016/j.ce...

Large diverse cohorts are the engine of #PrecisionMedicine New research using the #UCLAATLAS Biobank proves that ancestry-diverse genomic data uncovers novel disease associations, such as previously unreported risk loci. What other health critical ancestral differences await discovery?

New study in Nature shows #ImmuneAgeing starts early with T cell reprogramming and GATA3 activity. Adding antibody reactome profiling to these cohorts can reveal the extrinsic viral and environmental triggers of #Aging —a vital layer for the #MultiOmics stack. rdcu.be/fcrJT #HumanHealth

A new #HumanImmuneHealthAtlas published in Nature reveals that #ImmuneAgeing is a non-linear process starting earlier than we thought. By mapping these molecular transitions, we can better tailor vaccines and therapies to biological age, not just the clock. rdcu.be/fcrJT #Immunology #SystemsBiology

A new @cellcellpress.bsky.social study of 2,279 brain samples reveals deep molecular diversity in #Neurodegeneration. By mapping #Proteomics & PTMs, we move closer to #PrecisionMedicine and improved stratification between seemingly similar neurodegenerative diseases. www.cell.com/cell/fulltex...

New research in @natmed.nature.com reveals IgG1 producing #Bcells are key to cancer #immunotherapy success. Data from 2k+ patients show these cells coordinate with T-cells to drive anti-tumor immunity. A shift toward humoral-cellular strategies could transform outcomes. rdcu.be/e90xd

Humoral IgG1 responses to tumor antigens underpin clinical outcomes in immune checkpoint blockade

Nature Medicine - Transcriptomic and clinical data analyses from multiple cohorts of patients with cancer receiving immunotherapy find that PD-1 blockade potentiates tumor-specific IgG1 plasma cell...

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New study from #LifelinesNEXT cohort: a map of 31k+ gut viruses in mother-infant pairs. Key findings: vaginal birth & breastfeeding drive viral diversity, linked to future allergy risk. Large-scale longitudinal measurements generate unique findings for human health. doi.org/10.64898/202...

Thrilled to welcome Brian McKelligon as the new CEO of Infinity Bio! Brian's leadership will accelerate the reach of our #MIPSA technology and the inSIGHTs it delivers to researchers worldwide. Welcome to the team, Brian! #InfinityBio #AntibodyReactomics www.businesswire.com/news/home/20...

#MultipleSclerosis progression insights via #proteomic profiling: New study on MS reveals anti-viral response as a continuous disease driver, implicating #EBV infection beyond just a trigger. Highlights include sex-specific pathways for injury, repair & resilience. rdcu.be/e7ZWe #MSResearch

Infinity Bio's Katy Shaw-Saliba & Ben Larman just published a new study screening 85 Ig batches against 283,000+ viral peptides, uncovering pandemic-driven immune shifts & autoantibody changes. Discoveries like this begin with decoding the antibody reactome. doi.org/10.1002/eji....

Viral Immunity in Immunoglobulin Products: Global Immunity Debt and Autoimmunity in the Postpandemic Era

Immunoglobulin products derived from pooled global plasma reflect population-level antiviral immunity. Analysis of batches from 2017 to 2023 reveals pandemic-driven shifts in viral antibody profiles ...

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Researchers identified proteomic markers for #LymphoidCancer risk up to 10yrs before diagnosis. This large-scale discovery reveals how early molecular signatures like sCD23 can drive risk stratification & #EarlyDetection rdcu.be/e6GBZ%E2%80%8B #Proteomics #PrecisionMedicine #Biomarkers #Lymphoma

New research in #SjogrensDisease uses salivary & serum #Proteomics to link biomarkers with #HLA alleles and autoantibodies. Large-scale, multi-omic analysis like this reveals a dynamic immune record, paving the way for high-resolution patient stratification. doi.org/10.1016/j.ar...

Groundbreaking study in @natmetabolism.nature.com uses #MultiOmics to reveal #genes & #proteins causal to #T2D. With 85% of effects tissue-specific, large-scale profiling across ancestries is key to unlocking #global therapeutic targets. rdcu.be/e4zRC #PrecisionMedicine #TranslationalResearch

New Cohort of the Week from @nataging.nature.com! By analyzing nearly 1,000 human CSF samples, researchers mapped thousands of protein changes linked to #BrainAging and AD. #Proteomics on large human cohorts set the foundation for CNS markers of an aging brain. pmc.ncbi.nlm.nih.gov/articles/PMC...

A new study in @natcomms.nature.com re-analyzed WGS data from ~750k individuals to find viral "dark matter". By mapping viral reads, researchers linked persistent #EBV to #chronicdiseases like Lupus and Dementia. Large-scale omics are key to unlocking new disease #biomarkers Article: rdcu.be/e2cAt

New study in @natcomms.nature.com: A 29-protein blood signature predicts #cancer in patients with vague symptoms. Crucially, it distinguishes malignancy from #autoimmune & infectious diseases. A vital triage tool to prioritize life-saving diagnostics. #PrecisionMedicine Read: rdcu.be/eZ6bE

A new study leverages a well characterized infant cohort to explore our #microbiome & immune health. Researchers analyzed 647 infants in the #COPSAC cohort & found environmental exposure (daycare, siblings) reduced anellovirus abundance, consistent with immune "training." #Virome #ImmuneSystem

New Nature Medicine research maps blood #biomarkers related to #aging. By analyzing 54 biomarkers related to accumulated disease over 15 years, researchers identified key "biological signatures" predictive of aging. Large cohort studies are transformative for predictive health! #geroscience

New research reveals a link between Epstein-Barr virus (EBV) & Primary Sclerosing Cholangitis. Systematic #immuneprofiling shows that #PSC associated T & B cells target #EBV, suggesting it may drive pathogenesis. www.nature.com/articles/s41... #Omics #LiverDisease #Autoimmunity #Bcell #Tcell

Great news in neurodegeneration research! Hok-A-Hin et al. used large-scale CSF proteomics on a multicenter cohort to identify new biomarkers for Frontotemporal Dementia (FTD). Importantly, identified biomarker panels distinguish FTD from Alzheimer’s in presymptomatic cases. lnkd.in/eatVVT6K

New research sheds light on the food allergy. Gill, et al. found that children with food sensitization have gE B-cells that are less mature, more diverse. This was abrogated (stopped) by having a pet dog in the first year of life, supporting the hygiene hypothesis. doi.org/10.1111/all....

Cohort of the Week: Exciting new study on a large cohort of Guillain-Barré syndrome patients. Glycolipid complex auto-antibody patterns cluster into groups linked to clinical features. A step towards personalized medicine for the diagnosis, prognosis, & treatment of GBS. doi.org/10.1093/brai...

Lupus (SLE) symptoms are notoriously varied. New research groups patients into 6 'serological subsets' based on autoantibody profiles. Links to genetic factors (NCF2, HLA) help predict specific outcomes, like blood disorders or lower rates of kidney disease. www.translationalres.com/article/S193...

Diagnosing TB in children is a persistent challenge, as sputum-based tests are often ineffective. A new study used advanced plasma proteomics to identify a non-sputum-based biosignature for TB. The identified signatures meet WHO accuracy guidelines for a pediatric TB diagnostic. Read: rdcu.be/eOtzp