#ResultatScientifique🔎| Camille Attané et ses collaborateurs décrivent une population de cellules jusqu'alors inconnue dans la moelle osseuse humaine ! 👋 @ipbstoulouse.bsky.social 📕 @cp-cellreports.bsky.social À lire sur notre site internet ! ⤵️

Un nouveau type de cellules graisseuses sans noyau découvertes dans la moelle osseuse humaine

Dans u

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𝐍𝐚𝐭𝐮𝐫𝐚𝐥 𝐏𝐡𝐨𝐏𝐑 𝐯𝐚𝐫𝐢𝐚𝐧𝐭𝐬 𝐟𝐫𝐨𝐦 𝐝𝐢𝐟𝐟𝐞𝐫𝐞𝐧𝐭 𝐓𝐁 𝐛𝐚𝐜𝐢𝐥𝐥𝐮𝐬 𝐥𝐢𝐧𝐞𝐚𝐠𝐞𝐬 𝐬𝐞𝐧𝐬𝐞 𝐡𝐨𝐬𝐭-𝐥𝐢𝐤𝐞 𝐜𝐮𝐞𝐬 𝐝𝐢𝐟𝐟𝐞𝐫𝐞𝐧𝐭𝐥𝐲 Zn and Cd emerge as new PhoPR inducers, and variant-specific signaling differences translate into different virulence outcomes. 📖 shorturl.at/ZBrAh ✍️ E. Meunier & coll. @ipbstoulouse.bsky.social @asm.org

𝐋’𝐈𝐏𝐁𝐒 𝐯𝐢𝐞𝐧𝐭 𝐝’𝐚𝐜𝐪𝐮𝐞́𝐫𝐢𝐫 𝐥’𝐮𝐧 𝐝𝐞𝐬 𝐭𝐨𝐮𝐭 𝐩𝐫𝐞𝐦𝐢𝐞𝐫𝐬 𝐬𝐩𝐞𝐜𝐭𝐫𝐨𝐦𝐞̀𝐭𝐫𝐞𝐬 𝐝𝐞 𝐦𝐚𝐬𝐬𝐞 𝐎𝐫𝐛𝐢𝐭𝐫𝐚𝐩™ 𝐀𝐬𝐭𝐫𝐚𝐥™ 𝐙𝐨𝐨𝐦 𝐢𝐧𝐬𝐭𝐚𝐥𝐥𝐞́𝐬 𝐞𝐧 𝐅𝐫𝐚𝐧𝐜𝐞. Une avancée majeure pour la #protéomique à haut débit et à cellule unique, avec des perspectives inédites pour le phénotypage à grande échelle. #singlecell @genotoul.bsky.social

Truly humbled and deeply honored to have been elected a Fellow of the European Academy of #Microbiology, @femsmicro.org Profoundly grateful to my mentors, collaborators, colleagues, and students, past and present, whose guidance, creativity, and dedication have shaped this journey 🙏 ♥️

I’m pleased 🤗 to share our new preprint exploring the mode of action and resistance of the antitubercular drug pyrazinamide (PZA) 💊 Thanks to everyone who have participated 🙌 We hope these findings will help the fight against drug resistance in tuberculosis. www.biorxiv.org/content/10.6...

Our new paper is out in @lsajournal.org We explored how glycolysis inhibition in tuberculosis-infected macrophages can reduce HIV-1 spread. 🔗 Read it here: doi.org/10.26508/lsa... Huge thanks to @Zoi Vahlas, @lucianabalboa.bsky.social, @oneyrolles.bsky.social & @chrisverollet.bsky.social

How can bacterial pathogens weather metal ion stress during infection? @pierredupuy.bsky.social, @oneyrolles.bsky.social et al implicate ‘effluxosomes’, membrane clusters of metal-binding chaperones & exporters coordinating M. tuberculosis resistance to toxic metals link.springer.com/article/10.1...

Membrane-associated effluxosomes coordinate multi-metal resistance in Mycobacterium tuberculosis - The EMBO Journal

Bacterial pathogens must withstand metal-induced stress during infection, yet the mechanisms by which they sense and respond to toxic metal ions remain incompletely understood. Here, we uncover a prev...

link.springer.com

#ResultatScientifique🔎| La bactérie responsable de la tuberculose est capable d'évacuer les métaux toxiques pour résister au système immunitaire ✍️ @oneyrolles.bsky.social 🤝 @ipbstoulouse.bsky.social 📕 buff.ly/4R5iaMB ▶️

Tuberculose : comment la bactérie évacue les métaux toxiques pour résister au système immunitaire

Le bacille de la tuberculose survit dans les cellules immunitaires en neutralisant des métaux toxiques comme le zinc.

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🥳 𝐄𝐱𝐜𝐢𝐭𝐞𝐝 𝐭𝐨 𝐬𝐡𝐚𝐫𝐞 𝐨𝐮𝐫 𝐥𝐚𝐭𝐞𝐬𝐭 𝐰𝐨𝐫𝐤 𝐬𝐡𝐨𝐰𝐢𝐧𝐠 𝐡𝐨𝐰 𝐩𝐨𝐥𝐲𝐬𝐢𝐚𝐥𝐲𝐥𝐚𝐭𝐢𝐨𝐧, 𝐚 𝐫𝐚𝐫𝐞 𝐩𝐫𝐨𝐭𝐞𝐢𝐧 𝐦𝐨𝐝𝐢𝐟𝐢𝐜𝐚𝐭𝐢𝐨𝐧, 𝐫𝐞𝐠𝐮𝐥𝐚𝐭𝐞𝐬 𝐢𝐧𝐟𝐥𝐚𝐦𝐦𝐚𝐭𝐨𝐫𝐲 𝐦𝐨𝐧𝐨𝐜𝐲𝐭𝐞 𝐦𝐨𝐛𝐢𝐥𝐢𝐳𝐚𝐭𝐢𝐨𝐧 𝐟𝐫𝐨𝐦 𝐭𝐡𝐞 𝐛𝐨𝐧𝐞 𝐦𝐚𝐫𝐫𝐨𝐰. ✍️ Aurélien Boyancé, Nelly Gilles, @yoannrombouts.bsky.social & coll. @ipbstoulouse.bsky.social 📖 shorturl.at/IDwza 👇 A short thread...

𝐖𝐞 𝐚𝐫𝐞 𝐩𝐥𝐞𝐚𝐬𝐞𝐝 𝐭𝐨 𝐬𝐡𝐚𝐫𝐞 𝐞𝐱𝐜𝐢𝐭𝐢𝐧𝐠 𝐧𝐞𝐰𝐬 𝐢𝐧 𝐈𝐧𝐝𝐨-𝐅𝐫𝐞𝐧𝐜𝐡 𝐬𝐜𝐢𝐞𝐧𝐭𝐢𝐟𝐢𝐜 𝐜𝐨𝐥𝐥𝐚𝐛𝐨𝐫𝐚𝐭𝐢𝐨𝐧 🇮🇳🇫🇷 With IFCPAR/CEFIPRA funding, Albertus Viljoen will co-coordinate a project with Prof. Madhavan K. Nampoothiri (CSIR-NIIST, India) on mycobacterial biofilms and antimicrobial resistance. More details: shorturl.at/EI0VY

Albertus Viljoen Leads Indo-French Collaborative Research on Mycobacterial Biofilms - IPBS-Toulouse

The Indo-French Centre for the Promotion of Advanced Research (IFCPAR/CEFIPRA) fosters cutting-edge scientific collaboration between[…]

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🚨 We are excited to announce that @virginiestevenin.bsky.social has been awarded a starting grant from the @frm-officiel.bsky.social to establish her research team at IPBS and study the nutrition of pathogenic bacteria inside human host cells. More info: shorturl.at/U6zSa #MicroSky #Salmonella

🚨 We are excited to announce that @virginiestevenin.bsky.social has been awarded a starting grant from the @frm-officiel.bsky.social to establish her research team at IPBS and study the nutrition of pathogenic bacteria inside human host cells. More info: shorturl.at/U6zSa #MicroSky #Salmonella

🚨 𝐍𝐞𝐰 𝐩𝐫𝐞𝐩𝐫𝐢𝐧𝐭 𝐟𝐫𝐨𝐦 𝐨𝐮𝐫 𝐥𝐚𝐛, 𝐚𝐧𝐝 𝐚 𝐟𝐢𝐫𝐬𝐭 𝐢𝐧 𝐭𝐡𝐞 𝐓𝐁 𝐟𝐢𝐞𝐥𝐝! 🚨 We’re thrilled to share our new study revealing how the chromatin regulator SP140 preserves protective T cell immunity during #tuberculosis infection by restraining harmful type I IFN responses. 📖 𝗥𝗲𝗮𝗱 𝘁𝗵𝗲 𝗽𝗿𝗲𝗽𝗿𝗶𝗻𝘁: shorturl.at/r5jd9

𝗜𝗣𝗕𝗦 𝗿𝗲𝘀𝗲𝗮𝗿𝗰𝗵𝗲𝗿𝘀 𝗶𝘀𝗼𝗹𝗮𝘁𝗲𝗱 𝗵𝘂𝗺𝗮𝗻 𝗿𝗲𝗴𝘂𝗹𝗮𝘁𝗼𝗿𝘆 𝗯𝗼𝗻𝗲 𝗺𝗮𝗿𝗿𝗼𝘄 𝗮𝗱𝗶𝗽𝗼𝗰𝘆𝘁𝗲𝘀 𝗳𝗼𝗿 𝘁𝗵𝗲 𝗳𝗶𝗿𝘀𝘁 𝘁𝗶𝗺𝗲! These anucleate fat cells still metabolize lipids and glucose, support blood cell production, and may shape the bone marrow niche and hematopoiesis.🩸 📖 shorturl.at/bunUV #Hematopoiesis #Adipocytes #BoneMarrow

Hey friends. I’m looking for a postdoc interested in studying host-pathogen interactions and immunology of tuberculosis. Send me some good people! We have a great group here! Email me joanne@pitt.edu. Thanks!

IPBS researchers created LiveLung-TB, a BSL-3 imaging platform that visualizes real-time immune responses in Mtb-infected lungs. They found most CD4 T cells fail to reach infected cells, revealing physical barriers that limit TB immunity—a new window into host-pathogen dynamics! 🔬🫁 #Tuberculosis

#RésultatScientifique 🔎 | Comment les filaments d'actine s'organisent à l'intérieur des cellules et des tissus vivants 🔬 @institutfresnel.bsky.social 🤝 @univ-amu.fr @centralemed.bsky.social @cnrs.fr 📍 @cnrs-dr12.bsky.social

Comment les filaments d'actine s'organisent à l'intérieur des cellules et des tissus vivants

En utilisant la microscopie de fluorescence résolue en polarisation, les biologistes et physiciens de l'Institut Fresnel, associés à une équipe internat

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We are thrilled to congratulate @lucianabalboa.bsky.social, co-leader of our IPBS/CNRS-CONICET lab, for receiving a special mention in the L’Oréal-UNESCO “For Women in Science” Award 2025. This honor recognizes her exceptional career & dedication to research in infectious diseases. shorturl.at/Gfo4a

A huge thank you to our PhD students, the organizing committee, and our guest speakers @mblokesch.bsky.social, F. Mechta-Grigoriou & E. Crubezy for making the 10th IPBS Student Symposium such a success. Kudos to everyone involved! On to the 11th Symposium! 🎉

Un immense merci à nos doctorants, au comité organisateur et à nos orateurs invités @mblokesch.bsky.social, F. Mechta-Grigoriou & E. Crubezy, pour la réussite de ce superbe 10e Symposium des étudiants de l’IPBS. Bravo à toutes et à tous ! Cap sur le 11e Symposium !

Exciting #postdoc opportunity in KL Ung's group! Understanding the molecular mechanisms of cell wall remodeling in pathogens Learn more: shorturl.at/gPuFV Deadline: January 15, 2026 Contact: recruit@ipbs.fr #Protein #Biochemistry #StructuralBiology #Biophysics #CryoEM

Exciting #postdoc opportunity in T. Gensollen's group! How early-life interactions between the immune system and microbiota shape lifelong immune imprinting and disease risk Learn more: shorturl.at/F8hqE Deadline: January 15, 2026 Contact: recruit@ipbs.fr #Immunology #Microbiology #Microbiota #Omics

Des chercheurs de l’IPBS (@chrisverollet.bsky.social et coll.) ont découvert que la protéine moésine régule les ostéoclastes, les cellules qui résorbent l’os. Sans elle, les os s’affaiblissent. Une piste prometteuse contre l’ #ostéoporose. 📘 @jcb.org shorturl.at/OhNSa

La protéine Moésine régule le remodelage osseux en modulant la fusion et l’activité des ostéoclastes - IPBS-Toulouse

Des chercheurs de l’Institut de Pharmacologie et Biologie Structurale (IPBS) ont mis en évidence un[…]

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Too much cell fusion can break your bones, literally! IPBS researchers @chrisverollet.bsky.social & coll. found that moesin keeps bone-resorbing cells (osteoclasts) in check. Without it, bones weaken, a discovery that could inspire new #osteoporosis treatments. 📘 @jcb.org shorturl.at/N0Esc

Moesin Protein Controls Bone Remodeling by Regulating Osteoclast Fusion and Function - IPBS-Toulouse

Researchers at the Institut de Pharmacologie et Biologie Structurale (IPBS) have uncovered a pivotal role[…]

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Vous êtes doctorant-e-s à Toulouse, toutes disciplines confondues, et souhaitez partager vos recherches avec le grand public dans une ambiance conviviale ? Rejoignez le PhD-Pub Toulouse ! 📍 Lieu : Pub l’Autruche,Toulouse 📢 Les inscriptions pour la saison 2026 sont ouvertes -> phd-pub.ipbs.fr

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La saison 2025-2026 du PhD-Pub Toulouse ouvre ses portes !Vous êtes doctorant à Toulouse, toutes disciplines confondues, et souhaitez partager vos recherches avec le grand public dans une ambiance conviviale ?

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Le PhD-Pub Toulouse, c'est 4 présentations de 10 minutes, accessibles et interactives, des échanges libres entre le public et les doctorants, alors rejoignez nous pour échanger et s'amuser en parlant science le 21 octobre. Tous les informations et les portraits des doctorants : phd-pub.ipbs.fr

Pink October campain: In 2025, IPBS researchers advance the fight against breast cancer with innovative therapies and patient-focused treatments. Together, we progress science and hope for a cancer-free world. www.ipbs.fr/a-year-of-ca... #PinkOctober #BreastCancer #IPBS #Research #Hope

#ResultatScientifique🔎| Un transporteur spécifique du bacille de la tuberculose pourrait être la cible de médicaments ? ✍️ @oneyrolles.bsky.social 🤝 @ipbstoulouse.bsky.social 📕 @pnas.org | buff.ly/XAynagm

Un point faible du bacille de la tuberculose identifié

Dans une étude parue dans PNAS, des scientifiques dévoilent que la survie d

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Excited to share Wendy Le Mouëllic’s PhD work, now published in @pnas.org! It reveals that M. tuberculosis depends on inorganic sulfate import to survive inside host cells—fueling essential processes such as redox balance and stress resistance. Huge congrats to Wendy & colleagues! shorturl.at/WbFQC

Inorganic sulfate is critical for Mycobacterium tuberculosis lung tissue colonization and redox balance | PNAS

Tuberculosis remains the deadliest infectious disease caused by a single pathogen, highlighting the urgent need for novel therapies. A deeper under...

pnas.org

Another memorable #TBVACHORIZON WP1 working group meeting in Basel, Switzerland! Grateful to #TBVI and many thanks to Daniel Pinschewer and colleagues for the warm welcome and inspiring discussions. @unibas.ch @horizoneu.bsky.social