UPENN_ITMAT
@itmat.bsky.social
ITMAT was launched formally in January 2005; the first Institute of Translational Medicine And Therapeutics in the world.
Foundation to understand #BiologicalMechanism of #CentromereEvolution and its implications for #Chromosome segregation fidelity and #HumanDisease doi.org/10.1038/s415... @glennislogsdon.bsky.social #Centromere #TranslationalScience
A global view of human centromere variation and evolution - Nature
Complete sequencing of more than 2,000 centromeres from diverse humans reveals structures and elevated mutation rates that shape the evolution of these critically important regions.
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Plasticity in #CellCellCommunication may be central for how cell fate is robustly established in complex patterned tissues doi.org/10.1038/s415... @ksusztak.bsky.social #SingleCellRNASequencing #SpatialTranscriptomics #KidneyDevelopment
Single-cell spatial mapping of human kidney development implicates the microenvironment in guiding cell fate decisions - Nature Genetics
The spatial organization of human kidney development is explored using single-cell RNA sequencing and spatial transcriptomics, highlighting the crucial role of microenvironmental signals in guiding ce...
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Telomere length within normal human range represents critical determinant of hematopoietic reserve capacity under proliferative stress doi.org/10.1016/j.jb... #TelomereBiologyDisorders #DyskeratosisCongenita #HoyeraalHreidarssonSyndrome
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Uncovering new #TherapeuticOpportunities to reduce #Dyslipidemia and susceptibility to #LiverDisease by studying variants of glucokinase regulatory protein doi.org/10.1016/j.mo... @PaulTitchenell #GKRP #CholesterolMetabolism #TranslationalScience
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WHERE ART AND SCIENCE MEET: community still life + student showcase. ITMAT Education invites you to draw, observe and reflect this Thursday from 5-7 PM at the Institute of Contemporary Art, RSVP required, virtual option available, details on flyer
Neither #Microbiome nor LPS-TLR4 #Signaling is required for #CerebralCavernousMalformations formation in the adult #MouseModel insight.jci.org/articles/vie... #Brain #VascularMalformation #NullResult #TranslationalScience
JCI Insight - Growth of PIK3CA-driven cerebral cavernous malformations does not require microbiome stimulation
insight.jci.org
Disentangling the role of #CircadianClocks in #Tanycytes with implications for sex-specific modulation of #BodyComposition and #Neurogenesis doi.org/10.1016/j.ce... @amitaseh @chronosleepinst #SexualDimorphism #Neuroscience #TranslationalScience
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Structured #Workforce feedback through embedded well-being consultants reduces lag between problem identification & solution implementation in #ClinicalCare catalyst.nejm.org/doi/10.1056/... #HealthSystemInnovation #BurnoutPrevention #TranslationalScience
The Blue Coats Program to Improve and Sustain Workforce Well-Being
Between August 2022 and April 2025, the Blue Coats team conducted multiweek interventions across multiple clinical sites to understand the daily frictions, delays, and tensions that shape the lived...
catalyst.nejm.org
Finetuning #Pharmacotherapy options for managing #Hypertension in #HeartFailure With #PreservedEjectionFraction
Prospective longitudinal cohort study of #BreastCancer patients determines potential #MolecularBiomarkers for #Cancer therapy-related #CardioToxicity doi.org/10.1093/eurh... #CardioOncology #CardioOnc #TranslationalS
Validate User
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#AI leverages biological data at scale for CAR T cell target discovery doi.org/10.1016/j.ce... @carlhjune #CARTcelltherapy #CellTherapy #CARTCell #LLM #TranslationalScience
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#MechanicalStress to #MetabolicDysfunction & #Contractile impairment with #Cytoskeletal #Remodeling & #AMPK #Signaling as potential #TherapeuticTargets in #HeartFailure doi.org/10.1016/j.ce... @MarguliesLab #TranslationalScience
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#UrinaryProteomics offer insight into #PatientOutcomes for #CongenitalDiaphragmaticHernia & #FallotTetralogy while reducing #PatientBurden
Moving towards a one-time therapy to permanently correct #Phenylketonuria metabolism doi.org/10.1016/j.om... @kiranmusunuru.bsky.social @ahrensnicklas.bsky.social #LipidNanoparticles #Nanomedicine #TranslationalScience
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Boosting the #Diagnostic rate for patients with suspected #Mendelian #GeneticDisorders doi.org/10.1016/j.gi... @yosephbarash.bsky.social #GenomeSequencing #ExomeSequencing #TranslationalScience
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Integrated multimodal #Imaging, #Omics & #Clinical approaches in the Penn Medicine BioBank advance understanding of #CoronaryMicrovascular #Biology
#CARTCell mediated desensitization strategies in #KidneyTransplant recipients at high risk of antibody-mediated #TransplantRejection www.nejm.org/doi/pdf/10.1... #CARTcelltherapy #Kidney #HLAsensitization #TranslationalScience
Kidney Transplantation in Two Highly Sensitized Candidates after CAR T-Cell Therapy | NEJM
HLA sensitization poses a major challenge to kidney transplantation for patients with end-stage kidney disease, especially for highly sensitized candidates. Attempts at antibody elimination (desens...
nejm.org
Harnessing the unexpected relationship between #Endocytosis and #CARTfunction: Pairing Rab5 with CAR expression may improve CART therapy outcomes doi.org/10.1084/jem.... #CARTcelltherapy #CellTherapy #CARTCell #TranslationalScience
Rab5 improves CAR T cell efficacy via reducing fratricide and maintaining surface CAR levels
Gu et al. show CAR T cell endocytic activity is lost after continuous tumor engagement. Introduction of Rab5 maintains functional CARs on the cell surface
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What are the mechanisms for NREM-to-REM sleep transitions? Check out www.nature.com/articles/s41... #Sleep #DeepSleep #REMsleep #SleepScience #TranslationalScience
Low-dimensional population dynamics in the brainstem gate REM sleep - Nature Neuroscience
Lozano et al. show that REM sleep is gated by low-dimensional brainstem network dynamics, in which opposing neuron populations across the midbrain and pons determine when transitions into REM sleep ca...
nature.com
The devil is in the detail: Cautionary tale on the evaluation of #CardiacTissue exposed to #Cardioplegia doi.org/10.1073/pnas... @AranyLab #Metabolomics #CardiacMetabolism #TranslationalScience
PNAS
Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...
doi.org
A #CaseReport highlights strategies to evaluate genotoxic effects associated with #AAVTherapy www.nejm.org/doi/full/10.... #Mucopolysaccharidosis #MPSI #GeneTherapy #TranslationalScience
Neuroepithelial Tumor with AAV Integration after Intracisternal Magna Vector Delivery | NEJM
Recombinant adeno-associated virus (AAV) vectors are predominantly nonintegrating, but rare genomic integration events have been associated with oncogenesis in neonatal murine models. Here we repor...
nejm.org
Uncovering the mechanisms how flexible & dynamic nature of genome architecture is hijacked in disease doi.org/10.1016/j.mo... #GenomeOrganization #FriedreichsAtaxia #FriedreichsAtaxiaNews #FACommunity #Frataxin #TranslationalScience
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Potential avenues for natural receptor ligand-based targeting of mRNA-LNPs to modify #EffectorTcell rapidly, efficiently, and transiently in vivo www.science.org/doi/epdf/10.... @ejohnwherry.bsky.social @drewweissmanlab.bsky.social #mRNA #LNPs
In vivo reprogramming of cytotoxic effector CD8 T cells via fractalkine-conjugated mRNA-LNPs
Fractalkine-conjugated mRNA-LNPs effectively target cytotoxic effector CD8 T cells for transient in vivo reprogramming.
science.org
New avenues to prevent and/or arrest #CerebralCavernousMalformation growth through targeting #TyrosineKinase TIE2 receptor doi.org/10.1084/jem....
TIE2 links MEKK3–KLF2/4 and PI3K signaling in cerebral cavernous malformation
Endothelial cell gain of MEKK3–KLF2/4 signaling confers CCM by increasing PI3K signaling. We show that the TIE2 receptor links MEKK3–KLF2/4 and PI3K signal
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Targeting endothelial #NAD synthesis limits pathological #Angiogenesis doi.org/10.1016/j.cm... @AranyLab #EndothelialCells #MetabolicRewiring #HypervascularDisease #TranslationalScience
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Advancing #Treatment options for #UnresectableHepatocellularCarcinoma by combining #TransarterialEmbolization with #PharmacologicInhibition of #Lactate dehydrogenase doi.org/10.1097/hep.... @PigiLab #TranslationalScience
Locoregional lactate dehydrogenase inhibition potentiates... : Hepatology
grams the tumor microenvironment (TME) toward glycolytic dependency, creating an opportunity to sensitize hepatocellular carcinoma (HCC) to metabolic inhibition. This study investigated whether pharma...
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#MechanisticInsight into #ConcentricHypertrophy: Activation of different kinases in distinct #Subcellular compartments spatially regulate global #ProteinSynthesis www.science.org/doi/epdf/10.... @Prosser_Lab #Cardiomyopathy #TranslationalScience
mTORC1 and nuclear ERK spatially control translation in cardiomyocytes through 4EBP1 phosphorylation
Nuclear ERK activation relocalizes protein synthesis in cardiomyocytes to promote concentric hypertrophy.
science.org
Cell-type-specific #EpigeneticAdaptation to support #BetaCellFunction with age www.nature.com/articles/s42... @kaestner_klaus #DiabetesResearch #MetabolicHealth #TranslationalScience
Epigenetic adaptation of beta cells across lifespan and disease - Nature Metabolism
Mapping of genome-wide DNA methylation patterns in human islet alpha and beta cells highlights age and type 2 diabetes dependent adaptations and compensatory responses to altered metabolic demands.
nature.com
Temporal regulation of #GlucoseMetabolism is governed by the endogenous #CircadianClock & less dependent on feeding rhythms doi.org/10.1371/jour... @WeljieLab #Physiology #MetabolicHealth #TranslationalScience
Glucose is dynamically regulated by time of day in humans and Drosophila
Circadian clocks are known to regulate metabolism, but the details of how they regulate glucose processing remains unclear. By integrating human metabolite profiling with isotope-tracing in Drosophila...
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