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Tempera_Lab

@itphilly.bsky.social

We’re a virology and chromatin lab digging into how Epstein-Barr Virus (EBV) rewires the host cell to cause cancer. We mix epigenetics, 3D genome biology, and metabolism to figure out how it all works—and how to stop it.

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Tempera_Lab@itphilly.bsky.social · 6mo ago

Excited to share our new study: Integrated transcriptomic and methylome analysis reveals retinoic acid pathway activation after decitabine treatment in EBV-associated gastric cancer | mBio #EBV #Epigenetics #CancerResearch #GastricCancer #DNAme #Transcriptomics journals.asm.org/doi/10.1128/...

Integrated transcriptomic and methylome analysis reveals retinoic acid pathway activation after decitabine treatment in EBV-associated gastric cancer | mBio

EBV+ gastric cancer contains hypermethylated DNA, and despite this distinct molecular phenotype, there are currently no Epstein–Barr virus (EBV)-specific treatments available. Using an FDA-approved in...

journals.asm.org

Tempera_Lab@itphilly.bsky.social · 7mo ago

Honored and grateful to be promoted to Professor. Thank you to the mentors, colleagues, students, and collaborators who made this possible.

The Wistar Institute@wistar.org · 7mo ago

Congrats to Dr. Italo Tempera on his promotion to Professor! After postdoc training in Wistar's Lieberman lab, he launched his own lab at Temple before returning to Wistar in 2020. Since then, he's published in top‑tier journals and had major grant success. 👏 Congrats! bit.ly/49mwnTv

Tempera_Lab@itphilly.bsky.social · 10mo ago

🧬 New from our Lab! Integrated transcriptomic + methylome profiling reveals that Decitabine activates the retinoic acid pathway in EBV-associated gastric cancer, uncovering how DNA demethylation reshapes viral–host signaling. #Epigenetics #EBV #CancerResearch www.biorxiv.org/content/10.1...

Integrated transcriptomic and methylome analysis reveals retinoic acid pathway activation after decitabine treatment in EBV associated gastric cancer

Epstein-Barr virus associated gastric cancer (EBVaGC) accounts for ∼9–10% of gastric cancers worldwide and is defined by a distinctive molecular profile, including extreme hypermethylation of the DNA....

biorxiv.org

Tempera_Lab@itphilly.bsky.social · last yr.

We are excited to share our recent work: EBNA leader protein orchestrates chromatin architecture remodeling during Epstein-Barr virus-induced B cell transformation url: academic.oup.com/nar/article/...

EBNA leader protein orchestrates chromatin architecture remodeling during Epstein-Barr virus-induced B cell transformation

Abstract. Epstein-Barr virus Nuclear Antigen Leader Protein (EBNA-LP) plays a pivotal role in the transformation of B cells by Epstein-Barr virus (EBV), fu

academic.oup.com

Katie Phang@katiephang.bsky.social · 2y ago

RFK Jr.: “Thank you [to the NIH] for public service. We’re going to give infectious disease a break for about eight years.” Kennedy wants to take a “break” from studying infectious diseases like COVID-19 and measles. www.nbcnews.com/politics/pol...

RFK Jr. comes ‘home’ to his anti-vaccine group, commits to ‘a break’ for U.S. infectious disease research

He has suggested without evidence that researchers and pharmaceutical companies are driven by profit to neglect chronic conditions.

nbcnews.com