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IUSM SNRI Stem Cell Research Group

@iustemcell.bsky.social

Updates and information about the Stem Cell Research Group at the Indiana University School of Medicine Stark Neurosciences Research Institute

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IUSM SNRI Stem Cell Research Group@iustemcell.bsky.social · last yr.

New collaborative paper by #IUStemCell members Feng Guo and Scott Canfield, "Engineering blood–brain barrier microphysiological systems to model Alzheimer's disease monocyte penetration and infiltration" pubs.rsc.org/en/content/a...

Engineering blood–brain barrier microphysiological systems to model Alzheimer's disease monocyte penetration and infiltration

Alzheimer's disease (AD) is a progressive and neurodegenerative disease, predominantly causing dementia. Despite increasing clinical evidence suggesting the involvement of peripheral immune cells such...

pubs.rsc.org

IUSM SNRI Stem Cell Research Group@iustemcell.bsky.social · last yr.

Check out the latest research from the lab of #IUStemCell member Scott Canfield! In this study, they demonstrate that excessive alcohol levels impair the integrity of the blood-brain barrier in human stem cell-derived models, contributing to the onset or worsening of neurological disorders.

Alcohol diminishes barrier integrity in human stem cell-derived brain microvascular endothelial cells: Role of reactive oxygen species

The World Health Organization has linked alcohol consumption to over 200 diseases including neurodegenerative diseases. A dysfunctional blood–brain ba…

sciencedirect.com

IUSM SNRI Stem Cell Research Group@iustemcell.bsky.social · last yr.

Congratulations to Feng Guo and his lab for their recent exciting publication in @cp-cellstemcell.bsky.social where they pursue the use of diffusible scaffolds for functional maturation of midbrain organoids! Very cool work!

Vascular network-inspired diffusible scaffolds for engineering functional midbrain organoids

Guo and colleagues developed vascular network-inspired diffusible (VID) scaffolds for engineering midbrain organoids, providing a versatile technology for organoid development and therapeutic innovati...

cell.com