Delighted to see this published! 🎉 Why do cells invest in such tight control of tubulin synthesis? @ac-almeida.bsky.social shows that even small increases in tubulin levels alter microtubule dynamics and disrupt multicellular architecture and viability. Bravo to the whole team 👏! 👉 rdcu.be/fu8ek

Tubulin autoregulation tunes microtubule dynamics to support multicellular architecture and viability

Nature Communications - Almeida AC et al. uncover the physiological role of a long-elusive feedback pathway that regulates tubulin biosynthesis. By tuning microtubule dynamics, this mechanism...

rdcu.be

Ana Coelho Almeida@ac-almeida.bsky.social · 2w ago

Hot off the press!! 🚨 Our work is now published in #NatureCommunications! We show that keeping tubulin levels in check is key for preserving microtubule dynamics, multicellular architecture and viability. A huge thank you to the @ivanagasic.bsky.social team for making this possible! 🙌 rdcu.be/fu8ek

The Mitotic Spindle Meeting in Dubrovnik, organized by Iva Tolić @ivatolic.bsky.social and Nenad Pavin, has been a real festival of mitosis! Fantastic science and community. While the spectacle goes on for another day, I’m leaving inspired and energized. #SpindleSroatia2026

The conference “Mitotic spindle: From living and synthetic systems to theory” is open! www.phy.pmf.unizg.hr/~mitosis/ Follow us #SpindleCroatia2026!

You are finishing your PhD and looking to continue in science? The Martin lab @biology-unige.bsky.social has an open postdoctoral position in cell biology to study cell-cell fusion. For more information, please consult mocel.unige.ch/research-gro.... Thanks for reposting!

New preprint from the lab 🎉: γ-tubulin is a novel target of the tubulin autoregulation pathway! Previously thought to exclusively target α- and β-tubulin mRNAs, we show that the TTC5–SCAPER–CNOT11 axis also degrades γ-tubulin mRNA, expanding the scope of this fundamental regulatory mechanism.

Sad to miss this year’s ASCB meeting! But the lab is represented - don’t t miss @ac-almeida.bsky.social and her poster P0101. She will take you into the world of tubulin quantity control, microtubule dynamics, cell and tissue architecture.

Ana Coelho Almeida@ac-almeida.bsky.social · 8mo ago

Heading to #CellBio2025 @ascbiology.bsky.social @embo.org? Stop by my poster P0101 tomorrow (Sun, 12:45 PM) in the session “Cytoskeleton and Motility-Microtubule Organization and Dynamics”. Looking forward to lively discussions on tubulin regulation & microtubule organization. See you in Philly!

Lab’s 2nd story aired today! Fantastic @ac-almeida.bsky.social cracks the cellular function of tubulin autoregulation - an over four decades old enigma! Read on to learn how she deployed human 3D cell culture models to link tubulin homeostasis to tissue organization & viability. Bravo Ana! 👏🏻🍾

Ana Coelho Almeida@ac-almeida.bsky.social · last yr.

🔎New preprint! We reveal a physiological role for tubulin autoregulation, fine-tuning microtubule dynamics and preserving 3D cellular architecture. Big thanks to @ivanagasic.bsky.social and team! Link below for all #cytoskeleton & #spheroid enthusiasts👇(1/5) www.biorxiv.org/content/10.1...

Arresting mitosis with visible light! Brilliant Victoria von Glasenapp from the Gotta and Winssinger labs @UNIGE develops a cool photo-caged PLK1 inhibitor, which we deploy in 3D spheroids to control mitosis with exquisite spatio-temporal precision. Check out the original article: lnkd.in/eTnzy5Nc

Spatio-temporal control of mitosis using light via a Plk1 inhibitor caged for activity and cellular permeability - Nature Communications

Light is a powerful tool for controlling biological processes. Here, the authors demonstrate its use to modulate inhibitor activity and diffusion, enabling precise control of cell division in multicel...

lnkd.in

When you come out of your midterm evaluation and your amazing team surprises you with these beauties 😍💐! Thank you, the ProMiCe team, for these flowers, support, and the brilliant work you are doing 🥰🙏!

Hello Bluesky community! What a better way to introduce myself and my research team than post our lab’s first paper freshly off press 🥳🍾 We reveal how tubulins regulate the stability of their mRNA via reversible sequestration of TTC5. Bravo A. Batiuk and all coauthors 👏🏻🥂 doi.org/10.1038/s414...

Soluble αβ-tubulins reversibly sequester TTC5 to regulate tubulin mRNA decay - Nature Communications

When tubulin proteins are present in excess, their encoding mRNAs are selectively degraded in a process initiated by the protein TTC5. Here, the authors show that tubulins themselves reversibly seques...

doi.org