Team eDyNAmiC is proposing a more holistic perspective by integrating extrachromosomal DNA (ecDNA) into the broader Hallmarks of Cancer framework. Read why in a new review published today in @cellpress.bsky.social www.cell.com/cell/fulltex...

A recipe for chaos: Extrachromosomal DNA and the hallmarks of cancer

When oncogenic genetic elements untether from chromosomes and no longer follow Mendelian inheritance, genomic chaos and accelerated evolution ensues. In this review, Wong et al. discuss the mechanisti...

cell.com

The Hallmarks of Cancer series by Hanahan and Weinberg have been the guiding principles in how I come to understand and study cancer as a scientist. This year is the 25th anniversary of HoC since its first publication in 2020..!

We further laid out a roadmap to accelerate drug target discovery (esp. chemical proteomics approaches) and clinical deployment to actualize ecDNA-directed therapy. We hope this could be helpful for people who are interested in exploring the therapeutic space of ecDNA-driven cancers. [2/2]

I'm thrilled to start my first bluesky post by highlighting the review paper Hyerim and I have been working really hard together - published just yesterday on Nature Reviews Drug Discovery. In this review, we outlined the latest ecDNA biology and corresponding therapeutic vulnerabilities [1/2] -

Nature Reviews Drug Discovery@natrevdrugdiscov.nature.com · 6mo ago

Targeting extrachromosomal DNA in human cancers www.nature.com/articles/s41... rdcu.be/e2kVS This new Review discusses ecDNA biology, challenges faced by current therapeutic and detection approaches and discoveries that highlight emerging therapeutic vulnerabilities