A #ScienceTranslationalMedicine study of T cells from patients with #lupus nephritis shows these cells are activated by local cytokines and could mediate injury in inflamed kidneys, with some T cells reactive to potentially latent Epstein-Barr virus and cytomegalovirus. https://scim.ag/4w0m54w
Cytokine-mediated activation of kidney-infiltrating CD8+ T cells enables their contribution to inflammation in human lupus nephritis
Kidney-infiltrating CD8+ T cells in human lupus nephritis are activated via local cytokines and have the capacity to amplify local inflammation.
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