1 in 10 people who used psychedelics in the past year reported experiencing physical or sexual violence during that use. That's from a new paper I co-authored in World Psychiatry, using a nationally representative US sample. The numbers are sobering.

Really resonate with this post about science "I have also stood at the edge of what we know and felt something else entirely. The places where a question opens into a larger question. Where the boundary between what I understand and what I am being asked to become starts to thin...

Looks like Osmind's ketamine "me too" formulation is getting closer to FDA approval, to add to esketamine. This time via IV, rather than intranasal. ir.nrxpharma.com/news-release...

New in JAMA Network Open: Psilocybin beat the nicotine patch 4-to-1 for smoking cessation (40.5% vs 10% for prolonged abstinence). Important study and impressive headline — but what happens when you look under the hood? A thread to unpack this finding. 🧵#psychedelicscience

PIPS is hiring a Research Associate to work on clinical trials of psychedelic-assisted therapy (MDMA, psilocybin). Starting summer 2026. Great for post-bac folks looking for research experience before grad school. portlandpsychotherapy.com/behavioral-science-research-coordinator-in-portland-oregon/

Research Associate in clinical psychedelic science - Portland Psychotherapy

Join an active clinical research lab at the forefront of psychedelic science. As a Research Associate, you will contribute to multiple clinical trials of Research Associate in clinical psychedelic sci...

portlandpsychotherapy.com

I was just interviewed on the Mentally Flexible Podcast about ACT and Psychedelics. It was a fun interview and I think covered some interesting ground about shame, transcendent emotions, and psychedelic experience. Hope you enjoy it! podcasts.apple.com/us/podcast/j...

Jason Luoma, PhD | ACT & Psychedelic Science

Podcast Episode · Mentally Flexible · March 5 · 52m

podcasts.apple.com

There seem to be a number of sources of data suggest that psychedelics may exert their effects through heightening positive affect and motivational systems (e.g., reward responding), not solely through dampening or reducing negative affect, which is more characteristic of antidepressants. A thread.

🧵 First clinical trial ever conducted in a state-regulated psychedelic program just published. Oregon's psilocybin program has served 20,000+ people but the majority are wealthy out-of-state travelers. This study targeted low-income participants to test feasibility. #psychedelicscience

approval to study psilocybin/COMP360 assisted therapy for PTSD we shall see if it is more effective than MDMA www.lucid.news/legislation-...

Legislation, Industry, and the Future of Psilocybin for PTSD - Lucid News

The FDA acceptance of Compass Pathway’s Investigational New Drug Application for their COMP360 compound as a possible therapy for PTSD introduces a new area of possible therapies using psilocybin.

lucid.news

Psychedelics are FDA "breakthrough therapies" - but breakthrough for whom? New analysis reveals 85% of US psychedelic trial participants are non-Hispanic White, raising urgent questions about who actually benefits from this "revolution" in mental health. 🧵 #psychedelicscience

Important new Nature Medicine review talks about the two neuroscience mechanisms related to psychedelics that appear to be replicating across species, brain scales, and research labs. The story: Acute chaos + lasting plasticity = therapeutic change 🧵#psychedelicscience

🌿 Announcing the 2026 Perspective Psychedelic Training Retreat for healthcare professionals July 3-10, 2026 | Netherlands A week-long immersive training in psychedelic-assisted therapy grounded in ACT. Applications open now: perspectiveretreats.com/application-process

After being held in two of them as a boy, I fought for decades urging America to never again build concentration camps and put human beings in them. It breaks my heart to watch this happen twice now in my own lifetime.

🧪IMPORTANT! This graphic explains how science all over the US is funded. Congress approved a 2% increase in the #NIH budget for FY 26. Buried in the bill- Shift of ~40% of grants to MYF. This will still result in a 35% DECREASE in the NUMBER of grants funded per yr. Russel Vought is behind this.

Fun 2025 post about random facts zhengdongwang.com/2025/12/21/t...

The best facts I heard this year

Zhengdong Wang’s personal website

zhengdongwang.com

Psychedelics don’t require ethical exemptions. We argue against “ethical exceptionalism” while supporting context-sensitive policies that uphold shared research and clinical standards. Distinctive effects ≠ new ethics. OA Link: www.researchgate.net/publication/...

(PDF) Are Psychedelics Ethically Exceptional After All? Some Further Reflections

PDF | In this response to commentators on our target article, we clarify and refine our position on claims of psychedelic ethical exceptionalism.... | Find, read and cite all the research you need on…

researchgate.net

Our clinical research postdoc in psychedelic science is still receiving applications through January 6th! Come join our awesome team! share.google/8eoBuA33dYa1...

Postdoctoral Research Fellowship in Clinical Psychedelic Science - Portland Psychotherapy

The Portland Institute for Psychedelic Science and Portland Psychotherapy Clinic, Research, & Training Center are offering a two-year research Postdoctoral Research Fellowship in Clinical Psychedelic ...

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Great to see some studies coming out on psilocybin for PTSD. Lots of facilitators in Oregon are using psilocybin to treat PTSD, but so far we are lacking data. Only one previous open label trial has been published that I know of. The authors just published a qualitative study from that study. A🧵

Ive seen this in papers I've reviewed. People, you can't trust the references that chatgpt generates! That's not how llms work. search.app/CRgw2

AI Is Inventing Academic Papers That Don't Exist -- And They're Being Cited in Real Journals

Academic articles from authors using large language model are creating an ecosystem of fake research that threatens human knowledge itself.

search.app

New psilocybin cognition study shows "significant improvements" in processing speed & executive function after treatment. But dig into the data and the picture gets complicated. A thread on why statistical significance does not equal clinical meaningfulness 🧵 #psychedelicscience

🐁 Very concerning finding: Psilocybin promotes brain tumour growth Authors caution against use of 5-HT2A agonists like psilocybin in patients with glioma, "given the profound and sustained tumor growth-promoting effects observed." Extends to other serotonergic drugs like LSD.

Another article about Oregon’s psilocybin system for those interested. From my vantage point seems like the system is relatively stable but probably shrinking some from increased competition from Colorado. Fewer people from the Midwest and east coast these days.

David@daverino.bsky.social · 8mo ago

“Many worry about how the program’s rules & fees have pushed the cost of a psilocybin session as high as $3,000, putting it out of reach for many just as psychedelics are gaining mainstream acceptance as a mental health treatment www.theguardian.com/us-news/2025...

This new @michellemonje.bsky.social preprint shows that #psilocybin promotes the rapid and persistent growth of... xenografted glioma in mice. 🫠 www.biorxiv.org/content/10.6... Enduring but maladaptive plasticity induced by #psychedelics. h/t @tylerekins.bsky.social @theborislab.bsky.social

Seems like the The "Memory Wars" are coming back - now with psychedelics. A few studies coming out, this one showing 42% of people with post-psychedelic difficulties linked them to childhood trauma. Centrally, some said they recovered memories they had NO prior recollection of. #psychedelicscience

Critical commentary on a recent paper reporting emergence of dissociated traumatic memories during psilocybin treatment now out in the Journal of Eating Disorders, with @trpwolff.bsky.social, @manojdoss.bsky.social, Lilian Kloft-Heller, and @henryotgaar.bsky.social. doi.org/10.1186/s403...

Questioning the recovery of dissociated traumatic memories under psilocybin: comment on “Therapeutic emergence of dissociated traumatic memories during psilocybin treatment for anorexia nervosa” - Journal of Eating Disorders

In their recent case report article, Peck and colleagues suggested that two patients recovered dissociated traumatic memories during psilocybin treatment for anorexia nervosa. These case reports are of clinical and scientific interest and confirm that psychedelics may induce vivid memory-like experiences. However, the reports warrant scrutiny. Here, based on what is known about recovered memories and the effects of psychedelics, we argue that the authors may not have adequately considered alternative explanations. The cases do not necessarily demonstrate that psilocybin induces recovery of dissociated traumatic memories or could treat dissociative amnesia. We further caution against the authors’ suggestion of explicitly preparing patients for the emergence of forgotten material.

doi.org

Looks like we have a 7th placebo controlled trial on microdosing psychedelics showing microdosing did not outperform placebo, this time for depression. #psychedelicscience www.linkedin.com/posts/justin...

Microdosing in Depression Trial Initial Results | Justin Hanka | 17 comments

I'm still in disbelief! 😯 After so many years of clinical trials and hope for this treatment for depression, the initial results are in, and its not what we expected or hoped for, but we learned a ...

linkedin.com

Two more rigorous placebo-controlled trials just came out that were negative on microdosing, this time with psilocybin. I think these are the 5th and 6th RCTs with negative results. NO cognitive or mood benefits compared to placebo. 🧵 #psychedelicscience

I had missed this interesting podcast from 2023 with Matt Johnson at Johns Hopkins, talking about his history of psychedelic research and thoughts on his groundbreaking study on psilocybin-assisted therapy for smoking cessation. #psychedelicscience

A comprehensive living systematic review on psychedelics & MDMA for mental disorders just launched - this a really important new resource for tracking the evidence in real-time. #psychedelicscience

Super important new paper on reports of challenging experiences by therapists who have participated in research trials of psychedelic-assisted therapy. Reveals huge rift between what providers believe is necessary and what industry is developing as a standard. #psychedelicscience