Jason Zhang Lab @ UCLA
@jasonzhanglab.bsky.social
PI Personal Account: bsky.app/profile/jasonzxzhang.bsky.social 🔗 https://www.jasonzhanglab.com/ Jason Zhang lab at UCLA bioengineering. Generative AI protein design to understand cancer signaling
It was great to host Amgen for a joint meeting between the Zhang lab and @yamadahunter.bsky.social lab!
Excited to announce another publication (review) on de novo protein design! We cover the status quo, challenges, and future directions of protein design. Read here: www.nature.com/articles/s41...
The past, present and future of de novo protein design - Nature
A Review of de novo protein design highlights key methodological advances and achievements, current challenges and future applications.
nature.com
Two of our senior scientists haven’t tried in-n-out so we went as a lab!
The first publication while at UCLA! We developed and utilized generative AI protein design methods for targeting the disordered and highly charged C-terminus of RAS to generate RAS isoform specific binders/inhibitors: www.sciencedirect.com/science/arti...
De novo design of Ras isoform selective binders
The four major isoforms encoded by RAS proto-oncogenes are differentially associated with cancer, but there are few isoform-specific binding reagents …
sciencedirect.com