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James DeGregori

@jdegregori.bsky.social

Prof at U of Colorado SOM. Researcher in the evolutionary biology of cancer, AML, and aging. Completely dog-dependent. Waiting for the next puzzling result....

21 Posts274 Follower 194 Folgt

Rob Noble @robjohnnoble.bsky.social · 3w ago

Nice to see this properly published: a framework for designing therapies targeting tumor-level dynamics rather than cell number. Led by Fred Thomas with contributions from @amdujon.bsky.social, @jdegregori.bsky.social, me, and many others apparently not on Bluesky. www.nature.com/articles/s41...

When effective anticancer therapies are, in fact, destabilizing the tumor’s Group Phenotypic Composition - npj Precision Oncology

npj Precision Oncology - When effective anticancer therapies are, in fact, destabilizing the tumor’s Group Phenotypic Composition

nature.com

CU Anschutz Cancer Center @cucancercenter.bsky.social · 5mo ago

#SkinCancerAwarenessMonth: Interim Director @jdegregori.bsky.social, shares his experience of having two instances of squamous cell carcinoma and how you can prevent skin cancer. Learn more about skin cancer: https://bit.ly/467Yv97

@edwardevansjr.bsky.social · 3mo ago

So many people to thank for huge efforts: Ferriol Calvet in Nuria Bigas Lopez lab in Barcelona, Fabio Marongiu in Sardinia, Emilia Lim in Vancouver, @charlesswanton.bsky.social, Faiz Jabbar, my primary research mentor @jdegregori.bsky.social , and so many more. It was a huge collaborative efort.

James DeGregori @jdegregori.bsky.social · 2mo ago

Join us in October at the Keystone Symposia on Hormonal Influences on Immunity and Cancer! hubs.la/Q04hBrFR0

Hormonal Influences on Immunity and Cancer Across the Lifespan | Keystone Symposia

Join us at the Keystone Symposia on Hormonal Influences on Immunity and Cancer Across the Lifespan, October 2026, in Breckenridge, with field leaders!

hubs.la

James DeGregori @jdegregori.bsky.social · 6mo ago

Explore emerging research with field leaders @keystoneSymposia.bsky.social Hormonal Influences on Immunity and Cancer Across the Lifespan, this October in Breckenridge! keysym.us/KSHormoneInflu27 #KSHormoneInflu27 www.keystonesymposia.org/conferences/...

Hormonal Influences on Immunity and Cancer Across the Lifespan | Keystone Symposia

Join us at the Keystone Symposia on Hormonal Influences on Immunity and Cancer Across the Lifespan, October 2026, in Breckenridge, with field leaders!

keysym.us

James DeGregori @jdegregori.bsky.social · 8mo ago

Of Barriers and Loops—How Evolution Limits Most Cancer Risks to Older Ages url: aacrjournals.org/cancerdiscov...

Of Barriers and Loops—How Evolution Limits Most Cancer Risks to Older Ages

AbstractThe risks and health consequences of cancers increase dramatically at older ages. To develop interventions to limit the impact of cancers, from preventative to therapeutic, we must seek both e...

aacrjournals.org

Rob Noble @robjohnnoble.bsky.social · 12mo ago

Join @cmaley.bsky.social, @lucielaplane.bsky.social, Joel Brown and Benjamin Spada for a live EvoChat discussion about "How we define cancer matters", hosted by the International Society for Evolution, Ecology and Cancer (ISEEC). Oct 1st at 8am PST, 11am EST, 5pm CEST ucsb.zoom.us/j/8313111375...

Abstract: Current definitions of cancer describe what cancer does but not what it is. Furthermore, they derive largely from human cases and may not apply to other multicellular organisms, especially those lacking a basal membrane. Comparative oncology, however, has shown that cancer occurs across a broad diversity of organisms. What definition should be adopted when framing cancer in a comparative and evolutionary perspective? And can an evolution-based definition be applied in clinical oncology? We will show that a universal definition of cancer not only helps provide a basis for progress in comparative oncology, but can also help to explain the diversity of cancer phenomena within humans.

Aguirre-Ghiso Lab @jaguirreghisolab.bsky.social · last yr.

Important findings from the @soledadsosalab.bsky.social at the @cdi-einstein.bsky.social at Montefiore Einstein Comprehensive Cancer Center on the mechanisms of dormant cutaneous melanoma awakening via midkine dependent signaling. Congrats on this story! www.biorxiv.org/content/10.1...

Midkine inhibits dormancy of disseminated melanoma cells

A significant factor in cancer-related mortality in melanoma is the appearance of intrinsically aggressive distal metastases. This recurrence frequently results from the awakening of dormant dissemina...

biorxiv.org

James DeGregori @jdegregori.bsky.social · last yr.

Check out the symposium on “Cancer in an evolutionary framework: across species and within individuals” at the ESEB conference in Barcelona this August. Flyer: www.canva.com/design/DAGjV... Abstract submission closes this Friday: eseb2025.com/call-for-abs...

Call for Abstracts – ESEB 2025. Congress of the European Society for Evolutionary Biology. Barcelona. Spain

eseb2025.com

James DeGregori @jdegregori.bsky.social · 2y ago

Check out the editorial from Montano, Seidl and me announcing a new virtual issue spanning multiple Wiley journals on Aging and Cancer. Reach out if you are interested in contributing! onlinelibrary.wiley.com/doi/10.1111/...

Aging and Cancer—Inextricably Linked Across the Lifespan

Aging (as old man wind) alters the trajectory of cancer (dangerous seas) through changes in the immune system and metabolism (among many others), leading to altered cancer epidemiology, pathogenesis,...

onlinelibrary.wiley.com

Rob Noble @robjohnnoble.bsky.social · 2y ago

Sign up now for a live discussion "From Elephants to Humans: Evolutionary Insights into Cancer" on Weds 22nd, 11am EST. @amyboddy.bsky.social, @athenaaktipis.bsky.social & me will explore how ecology and #evolbio shape #cancer across the tree of life. Free registration: asu.zoom.us/meeting/regi...

Welcome! You are invited to join a meeting: Discover How Evolution Shapes Cancer Across Species. After registering, you will receive a confirmation email about joining the meeting.

Join us for a live and unfiltered discussion of cancer across life, "From Elephants to Humans: Evolutionary Insights into Cancer," featuring Amy Boddy (UCSB) and Rob Noble (CSGUL). We will explore how...

asu.zoom.us

James DeGregori @jdegregori.bsky.social · 2y ago

And while I'm promoting the science of Aging and Cancer, check out the last issue of the journal Aging AND Cancer: onlinelibrary.wiley.com/toc/26438909...

Aging and Cancer: Vol 5, No 3

Aging AND Cancer is an open access, international journal focusing on aging as a central component of cancer evolution and progression.

onlinelibrary.wiley.com

James DeGregori @jdegregori.bsky.social · 2y ago

Check out the conference in Hainan China on Aging and Cancer. It's Dec 13-14 (starting 12th for those in the West), there is a virtual option (yea, you don't need to fly to China), a great line up of speakers, and it's FREE. www.icacconference.com/2024/

衰老与肿瘤国际研究中心

icacconference.com