Papers are like buses... You wait for ages, then two come along at once. Huge congrats to @bornanovak.bsky.social and @jefflotthammer.bsky.social for pushing and driving every aspect of this work, preprinted ~1 year ago to the day (Friday before BPS), now published! www.nature.com/articles/s41...

Accurate predictions of disordered protein ensembles with STARLING - Nature

The deep learning model STARLING can generate accurate ensembles of intrinsically disordered regions of proteins using only protein sequence as input.

nature.com

Borna Novak@bornanovak.bsky.social · last yr.

Excited to announce the newest member of the flock - STARLING (conSTruction of intrinsicAlly disoRdered proteins ensembles efficientLy vIa multi-dimeNsional Generative models). www.biorxiv.org/content/10.1...

modern day Picasso right here 👌🏻😂

Alex Holehouse@alexholehouse.bsky.social · last yr.

Now published in JCIM! Thanks to reviewers and our editor for pushing us to (hopefully) clarify a few things and ensure it's clear what PENGUIN is trying to do (and what it's NOT trying to do). Also, in case you were unsure, graphic design is our passion. pubs.acs.org/doi/full/10....

This tool is 🔥🔥🔥 Going to be a game changer. Congrats @bornanovak.bsky.social @jefflotthammer.bsky.social and @alexholehouse.bsky.social

Borna Novak@bornanovak.bsky.social · last yr.

Excited to announce the newest member of the flock - STARLING (conSTruction of intrinsicAlly disoRdered proteins ensembles efficientLy vIa multi-dimeNsional Generative models). www.biorxiv.org/content/10.1...

It was a pleasure to work closely together with Borna on this work. It’s super exciting pushing beyond what was possible with ALBATROSS alone. Like usual, we strive very hard to make sure our tools are not only as accurate as possible but also widely accessible for both experts and non-experts.

GitHub - idptools/starling: STARLING - conSTruction of intrinsicAlly disoRdered proteins ensembles efficientLy vIa multi-dimeNsional Generative models

STARLING - conSTruction of intrinsicAlly disoRdered proteins ensembles efficientLy vIa multi-dimeNsional Generative models - idptools/starling

github.com

Borna Novak@bornanovak.bsky.social · last yr.

Excited to announce the newest member of the flock - STARLING (conSTruction of intrinsicAlly disoRdered proteins ensembles efficientLy vIa multi-dimeNsional Generative models). www.biorxiv.org/content/10.1...

Yall I can hardly contain my excitement! I'm happy to share that I’m joining the new cohort of @HHMINews #HannaGrayFellows! I'm grateful for the opportunity to advance my research and connect with this great community.

HHMI@hhmi-science.bsky.social · 2y ago

Today we're thrilled to announce our 2024 #HannaGrayFellows! Please join us in welcoming and celebrating these outstanding early career scientists!

I’m excited to share my most recent manuscript describing an approach to assess local conformational sampling in simulations of intrinsically disordered proteins. This one’s for my computational biophysics aficionados www.biorxiv.org/content/10.1... a 🧵

Disentangling folding from energetic traps in simulations of disordered proteins

Protein conformational heterogeneity plays an essential role in a myriad of different biological processes. Extensive conformational heterogeneity is especially characteristic of intrinsically disorde...

biorxiv.org

A labor of love - our review on why IDRs matter for cellular function is live in Nat. Rev. Mol. Cell. Biol: www.nature.com/articles/s41... Working with Birthe Kraglund on this was such a pleasure, and we hope this review will be helpful to a broad audience!