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Jeff Mugridge

@jeffmugridge.bsky.social

I'm a scientist! Asst Prof at Univ of Delaware | RNA biochemistry, RNA modifications, (metallo)enzymology, structural biology, and chemistry | Postdoc at UCSF | PhD at UCBerkeley | he/him mugridgelab.org

98 Posts675 Follower570 Folgt
Jeff Mugridge@jeffmugridge.bsky.social · 4w ago

As the lab graduates more PhDs, I'm really feeling just how painful it is to constantly be losing your most senior people! 😭 (that's the goal of course! But it's still tough to always be sending off your best folks who've built up deep expertise on projects and techniques!)

Mugridge Lab@mugridgelab.bsky.social · 4w ago

Lots of turnover in the lab over the past academic year! Brittany Shimanski and Luke Calzini both finished PhDs (the 3rd + 4th PhDs from the lab)! Each did nice work on the selectivity and regulation of RNA demethylases; read their preprints here: doi.org/10.1101/2025... doi.org/10.1101/2025...

Luke and Brittany with a custom m6Am cap cake to celebrate their PhDs and their work on RNA demethylase FTO (which demethylates m6Am RNA modifications)
Jeff Mugridge@jeffmugridge.bsky.social · last mo.

💥 Final version of our Elp3 paper is now live @natcomms.nature.com! We show how the radical SAM enzyme Elp3 uses a molecular tunnel to transport acetate molecules and modify tRNA! We think our proposed mechanism answers long-standing questions about how this important enzyme works! rdcu.be/fq2bw

Elp3 uses a conserved molecular tunnel to transport acetate between distant active sites and catalyze tRNA wobble base modification

Nature Communications - tRNA modifications are essential for accurate translation, but how Elp3 catalyses them across distant active sites was unclear. Here, the authors show that Elp3 uses a...

rdcu.be

Jeff Mugridge@jeffmugridge.bsky.social · last yr.

💥Latest preprint from our lab is now live! We propose a crazy(!?) new mechanism for how the radical SAM enzyme Elp3 (a subunit of the Elongator complex) modifies tRNA! #RNAsky #enzymes 🧵...

Graphical abstract shows molecules of acetate traveling through a molecular tunnel in Elp3 that connects its distant active sites
bioRxiv Biochemistry@biorxiv-biochem.bsky.social · last yr.

Elp3 uses a conserved molecular tunnel to transport acetate between distant active sites and catalyze tRNA wobble base modification https://www.biorxiv.org/content/10.1101/2025.05.07.652618v1

Max Kozlov@maxkozlov.bsky.social · last yr.

🚨 BIG week for lawsuits against the NIH. Now 16 states have sued NIH and HHS for "engag[ing] in a concerted, and multi-pronged effort to disrupt NIH’s grants." "The result of these disruptions has been, in a word, devastating," they write. ag.ny.gov/press-releas...

Attorney General James Sues Trump Administration for Illegally Cutting Funding for Medical Research

NEW YORK – New York Attorney General Letitia James and a coalition of 15 other attorneys general today filed a lawsuit against the Trump administration for its

ag.ny.gov

SmithLabUMBC@smithlabumbc.bsky.social · last yr.

Our 28-yr U-RISE/MARC NIH grant that has served over 500 students and made us one of the top institutions producing African American students who go on to receive MD/PhDs in the United States was just cancelled yesterday. What a unnecessary and tragic end to such an impactful program...

Joshua Weitz@joshuasweitz.bsky.social · last yr.

Working with an interdisciplinary team, we have developed a website to communicate how the White House's proposed cuts to health research would cause losses of $16B and 68,500 jobs. Find out how your community may be impacted. Explore more at SCIMaP: scienceimpacts.org a 🧵

US map via scienceimpacts.org visualization of economic loss due to IDC cuts to 15% as part of Feb 7, 2025 executive order, with shading denoting intensity of cuts.
Philip Gourevitch@pgourevitch.bsky.social · last yr.

powerful detailed account of ICE captivity "To put things into perspective: I had a Canadian passport, lawyers, resources, media attention, friends, family and even politicians advocating for me...Imagine what this system is like for every other person in there" www.theguardian.com/us-news/2025...

I’m the Canadian who was detained by Ice for two weeks. It felt like I had been kidnapped

I was stuck in a freezing cell without explanation despite eventually having lawyers and media attention. Yet, compared with others, I was lucky

theguardian.com

Jeff Mugridge@jeffmugridge.bsky.social · last yr.

Anyone have tips for making active homemade Phusion polymerase? We have a plasmid (no his tag), and are doing purification by heat denaturation and then sizing, from which we get *a lot* of purified protein. But we can't see any polymerase activity from these purified preps!

Science Homecoming@sciencehomecoming.bsky.social · last yr.

Happy Homecoming to Biochemistry Professor and High School Science Olympian Jeff Mugridge from Central New York who wrote for The Post Standard about the rewards of science funding for NY health and economy 🍎 🧪🧬🔬🏠@jeffmugridge.bsky.social www.syracuse.com/opinion/2025...

Protect science funding driving innovation, investment in Syracuse (Guest Opinion by Jeffrey Mugridge)

Severe cuts to budgets and staff threaten to undermine the next generation of American scientists, writes professor who discovered his love of science as a Liverpool High student.

syracuse.com

Jeff Mugridge@jeffmugridge.bsky.social · last yr.

I wrote an opinion piece for my hometown newspaper in Central NY about attacks on NIH/NSF/research and why this harms not just US science but local jobs and economies. Thanks @sciencehomecoming.bsky.social for sparking these efforts! I encourage others to join in! www.syracuse.com/opinion/2025...

Protect science funding driving innovation, investment in Syracuse (Guest Opinion by Jeffrey Mugridge)

Severe cuts to budgets and staff threaten to undermine the next generation of American scientists, writes professor who discovered his love of science as a Liverpool High student.

syracuse.com