Dr. Jeffrey Millman
@jeffreymillman.bsky.social
Washington University School of Medicine Professor | Diabetes Researcher | Stem Cell Biologist | Bioengineer | Inventor | STEM Educator | Former MIT & Harvard | Former Biotech VP | https://sites.wustl.edu/millmanlab/
🚨 New paper from our lab! How do stem cell-derived islets respond to hypoxia and how does that compare to primary islets? Using single-cell RNA-seq, functional assays, & metabolic profiling, we found that the two islet sources respond in different ways www.nature.com/articles/s41...
🚨We have published our latest differentiation strategy for #stemcell derived islets. By depolymerizing F-actin at the beginning of differentiation, we enhanced β-cell formation, function, and safety for #diabetes cell therapy. 🧵below www.nature.com/articles/s41...
Depolymerizing F-actin accelerates the exit from pluripotency to enhance stem cell-derived islet differentiation - Nature Communications
This study demonstrates that cytoskeletal state at the onset of directed differentiation impacts the exit of stem cells from pluripotency and downstream lineage specification. These findings are utili...
nature.com
🚨 New paper from our lab in BMC Methods! We describe a simple, rapid, and cost-effective method to identify subcutaneously transplanted pancreatic human islet grafts using dithizone (DTZ) staining. #diabetes #stemcells #islets 🧵 link.springer.com/article/10.1...
Optimizing post-transplantation detection of subcutaneously transplanted islets using dithizone staining - BMC Methods
BMC Methods - Pancreatic islet transplantation is a promising therapeutic strategy to restore insulin independence in patients with type 1 diabetes mellitus. In addition to primary human islets,...
link.springer.com
🚨Excited to share our single-cell multi-omic atlas of #stemcell islet differentiation that predicts cell fate decisions and identifies causal regulators of lineage specification. You can start browsing the data now 👉 synbioelab.com/islettwin Preprint 👉 www.biorxiv.org/content/10.6...
From immigrating alone at 15 to pursuing a career in medicine - Check out the latest in our "Meet the Researcher" series. Tai Le is a post-bacc in my laboratory helping to develop a cure for diabetes endocrinology.wustl.edu/meet-the-res...
Meet the Researcher: Tai Le
Tai Lee of Millman Lab Most 15-year-olds are figuring out who they want to be. Tai Le was doing that too – just 9,000 miles from home, on his own. At just 15, Le immigrated to the United States fro…
endocrinology.wustl.edu
Honored to be appointed the Alan A. and Edith L. Wolff Professor of Endocrinology at @washumedicine. Grateful to my colleagues, trainees, and collaborators helping us to advance stem cell-derived islet therapies toward transformative treatments for type 1 diabetes.
Excited to share our new publications working with Dr. Albert Kim. We developed a stem cell model of glioblastoma (GBM) and uncovered how INSM1 programs a progenitor network that fuels GBM progression www.nature.com/articles/s41...
INSM1 governs a neuronal progenitor state that drives glioblastoma in a human stem cell model - Nature Communications
Glioblastoma (GBM) is characterized by a high degree of heterogeneity and plasticity due to interplay with neural developmental programs. Here, the authors develop a model of GBM by introducing sequen...
nature.com
(please share) Immediate #postdoc job opening in the Millman lab at WashU Med (St. Louis, MO). Want to develop next-generation pancreatic islets for the study and treatment of diabetes? Email your CV to apply sites.wustl.edu/millmanlab/
(please share) Immediate #postdoc job opening in the Millman lab at WashU Med (St. Louis, MO). Want to develop next-generation pancreatic islets for the study and treatment of diabetes? Email your CV to apply sites.wustl.edu/millmanlab/
Grateful to be celebrating this holiday season with these amazing scientists! We look forward to further advances in 2026! @WashUMedEndo @WashUDeptMed
Dr. Veronese-Paniagua and I just published a review examining type 1 diabetes (T1D) as the consequence of genetic susceptibility and environmental viral exposures converging to drive autoimmune destruction of pancreatic β cells. Check it out here! www.frontiersin.org/journals/end...
Frontiers | The perfect storm: unraveling the interplay of genetic predisposition and viral triggers in type 1 diabetes pathogenesis
Type 1 diabetes (T1D) is a chronic autoimmune disease characterized by the T cell-mediated destruction of insulin-secreting pancreatic β cells, leaving patie...
frontiersin.org
🚀 Ready to launch your postdoc journey? Check out WashU’s new Postdoc Passport for everything you need to get started. Register for the virtual event December 4th. postdoc.wustl.edu/prospective-...
PASSPoRT to WashU | Office of Postdoctoral Affairs | Washington University in St. Louis
Pathways to Advanced Scientific Skills through Postdoctoral Research Training (PASSPoRT) Register Here Thank you for considering WashU for your...
postdoc.wustl.edu
Congratulations #MillmanLab member Dr. Veronese Paniagua for successfully defending his PhD yesterday!
The #MillmanLab had a great time at the Breakthrough T1D walk yesterday! Happy to share our excitement for science with so many young people and support people living with #T1D!
The #MillmanLab is excited to be part of Vendor Village at the St. Louis @BreakthroughT1D Walk Sunday October 19! Come visit us to learn more about our cutting-edge research into stem cell-derived therapies for type 1 #diabetes and how we’re working toward a future without T1D.
The Millman Lab is proud to join the @BreakthroughT1D Walk in St. Louis on Oct 19 to support everyone living with type 1 diabetes. 🔗 Please consider donating to advance T1D research: www2.breakthrought1d.org/site/TR?fr_i...
Join our Breakthrough T1D Walk team and help create a world without type 1 diabetes (T1D).
Our team is walking and raising funds to support the most promising, cutting-edge science to create a world without T1D. Join us!
www2.breakthrought1d.org
Out today in @cp-cellreports.bsky.social! We found that coxsackievirus B3 (CVB3), associated with increased risk of #T1D, infects all human pancreas cell types, not just beta cells. Great collab w/ Hubert Tse (KUMC). Led by WashU DBBS PhD student Daniel Veronese-Paniagua www.cell.com/cell-reports...
Coxsackievirus B infection invokes unique cell-type-specific responses in primary human pancreatic islets
Veronese-Paniagua et al. demonstrate that coxsackievirus B3 infects all primary human islet cell types and elicits distinct cell-type-specific transcriptional and mitochondrial responses. They identif...
cell.com
[please retweet] I’m #hiring! The Millman Lab is looking for a postdoctoral researcher to lead an exciting new project focused on vascularized #stemcell-derived islets for #diabetes disease modeling and cell replacement therapy. Email me your CV and cover letter.
Join us for the 2025 Rachmiel Levine-Arthur Riggs Diabetes Research Symposium. We have an amazing program this year focusing on type 1 #diabetes. We have also extended the abstract submission deadline to Sept 19. Register and submit your abstract a www.levinesymposium.com
A few days ago marked my 10th anniversary as a faculty member at Washington University School of Medicine in St. Louis. I arrived in 2015 as an Assistant Professor, excited but nervous to start my own lab. Today, I’m a Full Professor, reflecting on an incredible decade. 🧵
New application note from R&D Systems showcases efficient, reproducible generation of iPSC-derived pancreatic islets based on our 2021 Nature Protocols paper. High purity (75–80% C-peptide+/NKX6.1+) & robust glucose-stimulated insulin secretion www.rndsystems.com/resources/li... #T1D
rndsystems.com
I had the privilege to work with several experts in T1D as part of a June 2024 international Expert Forum at ADA organized by the editors of Diabetes, Diabetes Care, and Diabetologia to write a review article on T1D heterogeneity, check it out! diabetesjournals.org/diabetes/art...
The Heterogeneity of Type 1 Diabetes: Implications for Pathogenesis, Prevention, and Treatment—2024 Diabetes, Diabetes Care, and Diabetologia Expert Forum
This article summarizes the current understanding of the heterogeneity of type 1 diabetes from a June 2024 international Expert Forum organized by the edit
diabetesjournals.org
New #diabetes publication in the NEJM. Sana Biotechnology provides evidence that gene-edited islets survive after transplantation into a patient without immunosuppressing drugs for several months www.nejm.org/doi/full/10....
Survival of Transplanted Allogeneic Beta Cells with No Immunosuppression | NEJM
The need to suppress a patient’s immune system after the transplantation of allogeneic cells is associated with wide-ranging side effects. We report the outcomes of transplantation of genetically m...
nejm.org
When you say yes to just one more committee and now you're chairing it
Meet Allison Kelley, a technician at WashU’s Millman Lab! A Biomedical Engineering grad from UMiami, she authored a new paper in Biotechnology & Bioengineering and is shaping her career at the intersection of science, medicine, and patent law #womeninSTEM sites.wustl.edu/millmanlab/p...
Meet the Researcher: Allison Kelley
By Erika Brown – July 7, 2025 Research Technicians are the backbone of research laboratories. They actively participate in various projects, acquiring knowledge that they can apply in their f…
sites.wustl.edu
Congratulations to @sydneal123.bsky.social on publication of the main body of work from her PhD thesis, now out in the Journal of Biomedical Materials Research Part A! dx.doi.org/10.1002/jbm....
Enhancing the Potency of Growth Factor‐Mimicking Peptides via Cross‐Presentation With Integrin Ligands
Growth factors enhance survival and integration of transplanted Mesenchymal Stromal Cells (MSC), but successful supplementation often requires supraphysiological growth factor doses, risking off-targ....
dx.doi.org
