Check how their research identifies SHP1 as a critical intracellular checkpoint that promotes tumor immune evasion by concurrently suppressing DC antigen presentation and the formation of central memory CD8+ T cells, nominating it as a promising therapeutic target for immunotherapy-resistant cancers

“SHP1 expression in tumor-associated dendritic cells drives immunoevasion via impairing CD8+ memory T cell responses” 🔵 Yuan Zhang‘s latest research is now available to read in #Oncogenesis. ▶️ Read the full open access article here: www.nature.com/articles/s41...

This review is included in the review collection "Metabolic Reprogramming in Cancer: Mechanisms and Therapeutic Opportunities", edited by Shensi Shen (@seansi.bsky.social) and Jean Ehrland Ricci (@jer-06.bsky.social). 🔗 Discover the Review Collection: www.nature.com/collections/...

and (3) explores the therapeutic potential of targeting iron-dependent processes beyond the scope of ferroptosis.

This review (1) discusses how iron-dependent pathways contribute to tumor development, (2) describes the relevance of iron crosstalk within the tumor microenvironment in promoting tumor growth, metabolic reprogramming and immune evasion...

“Iron and metabolic rewiring in cancer” 🔵 Excited to share the latest review from Naiara Santana-Codina, now available in #Oncogenesis. ▶️ Read the full review here: www.nature.com/articles/s41...

“Ubiquitin-specific protease 11 suppresses cuproptosis in colorectal cancer by regulating the ubiquitination and stability of ISCU” 🔵 Songling Yan‘s latest research is now available to read in #Oncogenesis. ▶️ Read the full open access article here: www.nature.com/articles/s41...

Check how this study reveals a novel regulatory pathway wherein USP11 promotes CRC progression by stabilizing ISCU and suppressing cuproptosis, contributing to tumor resistance against cuproptotic stress and highlights a potential therapeutic target for sensitizing CRC to copper-induced cell death.

It also describes approaches to target this signalling pathway, where aberrant, with the goal of eradicating the CSC population responsible for cancer initiation and progression, and importantly, patient relapse to many clinical therapeutics.

This review provides an overview of the role of Sphingosine 1-phosphate in stem cell biology in both normal physiology and disease.

“Sphingosine 1-phosphate signalling in cancer stem cells” 🔵 We're pleased to share the latest review by Jason A. Powell, and Stuart M. Pitson, now available in #Oncogenesis. ▶️ Read the full review here: www.nature.com/articles/s41...

Check how their findings support a model whereby HPCAL1 promotes CRC aggressiveness by sustaining canonical Wnt signaling, thereby functioning as a critical facilitator of the cellular plasticity required for metastatic progression.

“HPCAL1 promotes colorectal cancer progression via TCF7/p65-mediated Wnt ligand upregulation and Wnt/β-catenin pathway activation” 🔵 Zunmin Zhu‘s latest research is now available to read in #Oncogenesis. ▶️ Read the full open access article here: www.nature.com/articles/s41...

Check how their data strongly indicates that treatment with gemcitabine is well tolerated by FA/BRCA deficient mice and may provide an alternative treatment modality for chemoradiotherapy of HNSCC in Fanconi patients.

“Gemcitabine as chemotherapy of head and neck cancer in Fanconi anemia patients” 🔵 Interesting research led by Ruud H. Brakenhoff was featured in #Oncogenesis. ▶️ Read the full open access article here: www.nature.com/articles/s41...

“Inhibition of LIMK by Cofilin-1 peptidomimetics enhances actin depolymerization and reduces metastasis of non-small cell lung cancer” 🔵 Yi-Jang Lee‘s latest research is now available to read in #Oncogenesis. ▶️ Read the full open access article here: www.nature.com/articles/s41...

Check how their findings reveal the underlying mechanism of PLEKHA4 in regulating glioblastoma cell glycolysis and indicate a potential new target for GBM treatment.

Check how this work identifies the enhanced vulnerability of cyclin E-overexpressing TNBC cells to CDC7 kinase inhibition and substantial synergy when combined with CDK8 inhibition.

“Cyclin E modulates vulnerability to CDC7 kinase inhibition” 🔵 Agnieszka K. Witkiewicz‘s latest research is now available to read in #Oncogenesis. ▶️ Read the full open access article here: www.nature.com/articles/s41...

happy to share our review collection “Metabolic Reprogramming in Cancer: Mechanisms and Therapeutic Opportunities” @oncogenesisnature.bsky.social . A big thank you to all contributing authors. If you are interested in cancer metabolism, I encourage you to read these expert reviews. enjoy!!

Oncogenesis@oncogenesisnature.bsky.social · 2mo ago

🚀📚 Excited to share the launch of the review collection "Metabolic Reprogramming in Cancer: Mechanisms and Therapeutic Opportunities", edited by Shensi Shen (@seansi.bsky.social) and Jean-Ehrland Ricci (@jer-06.bsky.social). 📖 Discover the Review Collection: www.nature.com/collections/...

Check how this study shows that while prostasin deficiency does not affect primary tumor growth, it results in a significantly increased of metastasis due to the crucial role of fibronectin in tight junctions.

“Metastasis suppressing properties of the cell-surface anchored serine protease prostasin: new functional and mechanistic insights from breast cancer” 🔵 Karin List‘s latest research is now available to read in #Oncogenesis. ▶️ Read the full open access article here: www.nature.com/articles/s41...

Check how this study uncovers a mechanism whereby FBP1 can be regulated by a protein O-GlcNAcylation-polyubiquitination axis, paving the way to cancer cell metabolic reprogramming and tumour progression in pancreatic cancer.

“O-GlcNAcylation of FBP1 promotes pancreatic cancer progression by facilitating its Lys48-linked polyubiquitination in hypoxic environments” 🔵 Interesting research led by Wei Feng was featured in #Oncogenesis. ▶️ Read the full open access article here: www.nature.com/articles/s41...

Why does IRE1 sometimes promote tumors and sometimes fight them? We identify DPM1 as the rheostat controlling IRE1 activity. Low DPM1 sustains immunogenic IRE1 signaling, enhances CD8+ T-cell surveillance, and predicts better immunotherapy responses. www.nature.com/articles/s41...

Check how their findings demonstrate that PRMT6-dependent EZH2 methylation plays an important role in driving breast tumour growth, revealing a new epigenetic mechanism of PRMT6 in the breast cancer and highlighting PRMT6 inhibition as a potentially therapeutic strategy.

“PRMT6-mediated EZH2 arginine methylation is critical for breast cancer development” 🔵 Zhenhai Yu‘s latest research is now available to read in #Oncogenesis. ▶️ Read the full open access article here: www.nature.com/articles/s41...

Check how this study suggests that combining stemness gene intervention with TKIs may be a viable approach for treating FLT3-ITD+ AML and other tyrosine kinase-mutated leukemias.

“FLT3 inhibition upregulates OCT4/NANOG to promote maintenance and TKI resistance of FLT3-ITD+ acute myeloid leukemia” 🔵 Interesting research led by Yaming Xi was featured in #Oncogenesis. ▶️ Read the full open access article here: www.nature.com/articles/s41...

Check how this study identifies a previously unrecognized regulatory mechanism whereby cholesterol metabolic pathway drives TNBC lung metastasis through the SCAP-SREBP2-CCDC25-NETs signaling axis.