Ever wondered how different regions of the gut are established? 🤔 Stem cells, right? Turns out, not in the colon ❌. The microbiome 🦠 — via region-specific metabolism — is an important regulator of colonocyte identity. 📄 New paper out in Cell www.cell.com/cell/fulltex... 🧵 Thread below 👇
Microbiome-produced nicotinic acid controls colon regional identity and injury susceptibility
The gut epithelium is regionally patterned to support digestive functions. In the colon, this regionalization, which is extrinsically dictated by microbiome-derived signals rather than through intrins...
cell.com
