📣 Call for Papers! 📣 We welcome papers on Voltage-Gated Sodium Channels for a special issue, initiated in the context of the second Worldwide Sodium Channel Conference #WSCC26 in Switzerland, February 4 - 6, 2026. Submit here 👉 rupress.org/jgp/pages/ca... #IonChannels #CallForPapers

New Commentary: Zhang Feng discusses a new study from Stephens et al. (rupress.org/jgp/article/... ) showing how a hydrophobic interaction network between TM3 and TM4 stabilizes an ion-conductive conformation of the TMEM16A chloride channel. rupress.org/jgp/article/... #ChlorideChannels #IonChannels

Werner Melzer highlights new study from Rios and Pizarro (rupress.org/jgp/article/... ) which simulates allosteric interactions within the couplon using Markov chain modelling to successfully describe many characteristics of whole-cell and microdomain Ca2+ signals. rupress.org/jgp/article/...

📣 Call for Papers 📣 JGP welcomes papers on the topic of the @sgpweb.bsky.social 2026 meeting, “Membrane Excitability and Reproductive Biology,” to be published throughout the year and highlighted in a special issue! Learn more and submit here 👉 rupress.org/JGP/pages/ca...

Allosteric interactions between RyR channels justify intracellular Ca2+ release of skeletal muscle in quantitative detail. New study from Eduardo Rios (Rush University) and Gonzalo Pizarro (Universidad de la República, Uruguay): rupress.org/jgp/article/... #Biophysics #IonChannels #SkeletalMuscle

📣 2026 #CallForPapers on #Myofilaments is now open! The review process will be overseen by JGP Editor Henk Granzier, with Guest Editors and subject experts Brett Colson, Jonathan Kirk @jonathankirk.bsky.social, Julian Stelzer, and Jennifer Van Eyk. 👉 rupress.org/JGP/pages/ca...

#Electrophysiology in nanoscale compartments. New study from Madeleine R. Howell, Rosalind J. Xu, and Adam E. Cohen @harvard.edu: rupress.org/jgp/article/... #Biophysics #IonChannels

“JGP is also a journal I turn to for rigorous, impactful science, and it's wonderful when scientific excellence and a commitment to equity go hand in hand.”— Theanne Griffith (@doctheagrif.bsky.social). JGP, where scientists set the course 👉 hubs.la/Q04lcxPj0

Half of muscle RyR channels lack voltage sensor contact-so how do they activate? New model from Rios and Pizarro shows that allosteric propagation through the couplon explains it all. rupress.org/jgp/article/... #Biophysics #IonChannels #ComputationalBiology #SkeletalMuscle

Howell, Xu, & Cohen (@harvard.edu) provide a framework for predicting & interpreting bioelectrical dynamics in small structures, such as bacteria, viruses, & intracellular vesicles, where they are strongly affected by stochastic gating of single #ionchannels. rupress.org/jgp/article/... #Biophysics

Model prokaryotic potassium channels: Predictive power and relevance to eukaryotic channels. New Review from Philipp Schmidpeter (UTSA) and Crina Nimigean @weillcornell.bsky.social: rupress.org/jgp/article/... #Biophysics #Biochemistry #MembraneTransport #Lipids #membranes #IonChannels

Kinetic reconstruction of graded membrane excitability in #Paramecium. New tudy from Takashi Tominaga and Yoko Tominaga (Tokushima Bunri University): rupress.org/jgp/article/... #CellularPhysiology

#CallForPapers 📣 You are invited to submit papers on the topic “What’s Hot in #Myofilament Structure, Elasticity, and Regulatory Networks in Muscle Function and Disease.” Learn more & submit here 👉 rupress.org/JGP/pages/ca...

Evolution, hibernation, and inactivation of voltage-gated Na channels. New Hypothesis from John S. Willis @universityofga.bsky.social: rupress.org/jgp/article/... #IonChannels #Biochemistry #Biophysics #MolecularPhysiology #CardiacMuscle

From our July issue: rupress.org/jgp/issue/15... Representative images of HEK293 cells transfected with a membrane marker (red), Kv1.3-YFP (green), and KCNE4-CFP variants (blue). From Magalí Colomer-Molera, Daniel Sastre, and Antonio Felipe @ub.edu: doi.org/10.1085/jgp....

“JGP’s commitment signals to early-career scientists from underrepresented backgrounds that the broader biophysics and physiology community is invested in their success.” Theanne Griffith (@doctheagrif.bsky.social). Share your work in a journal by and for scientists 👉 hubs.la/Q04lcxPj0

Conformational changes upon pore blocker removal reveal conductive states of TMEM16A. New study from Christina A. Stephens, Frank V. Marcoline, Christian J. Peters (University of Illinois College of Medicine), and Michael Grabe (UCSF): rupress.org/jgp/article/... #ProteinStructure #ProteinDynamics

Philipp Schmidpeter (UTSA) & Crina Nimigean @weillcornell.bsky.social review how structurally simple prokaryotic potassium channels have consistently informed mechanisms in complex eukaryotic channels. rupress.org/jgp/article/... #Biophysics #Biochemistry #MembraneTransport #Lipids #IonChannels

Hearts of hibernating mammals continue to beat at near 0°C thanks to continued excitability. Several members of a minor group of voltage-gated Na channels in the heart are found to contain a mutation unique to hibernators. From John S. Willis @universityofga.bsky.social: rupress.org/jgp/article/...

Takashi Tominaga and Yoko Tominaga develop a kinetic framework for the major membrane-current components in #Paramecium. The framework integrates late-component, leak, and inward Ca2⁺ currents, including Ca2⁺-dependent inactivation and slow recovery. rupress.org/jgp/article/...

Label-free real-time imaging of mitochondrial matrix volume changes and permeability transition in living cells. New Methods and Approaches from Yaw Akosah, Paolo Bernardi, Evgeny V. Pavlov and colleagues (New York University): rupress.org/jgp/article/... #CellBiology #Mitochondria

On the mechanism of #hypomagnesemia with treatment-resistant seizures caused by variants of the Na⁺,K⁺-ATPase α1 subunit (ATP1A1). New study from Nicolas Colmano, Daniel Self, Pablo Artigas (Texas Tech University Health Sciences Center) and colleagues: rupress.org/jgp/article/... #Biophysics

📣 Call for Papers 📣 JGP welcomes submissions that focus on increasing our understanding of the role of voltage-gated sodium channels in the broad physiological and pathophysiological context. 👉 rupress.org/jgp/pages/ca... #IonChannels #CallForPapers #WSCC26

Differential regulation of β1-dependent voltage shifts and kinetic modulation by an extracellular glutamate in NaV1.6 VSDIV. New study by Maxime Lammens, Frank Bosmans et al. (Ghent University) rupress.org/jgp/article/... #IonChannels #Biophysics #MolecularPharmacology

Our July issue is here! rupress.org/jgp/issue/15... The cover shows neural coding in the electrosensory system of weakly electric fish. From Amin Akhshi, Maurice J. Chacron, Anmar Khadra et al. doi.org/10.1085/jgp....

Mechanistic insights into DCPIB inhibition of VRAC: Electrostatic control and binding plasticity. New study from Héctor Gaitán-Peñas, Salomé Llabrés, Marina Pedrola, Rodolfo Lavilla, Raul Estevez and colleagues @ub.edu: rupress.org/jgp/article/... #ComputationalBiology #ChlorideChannels

The conductive state of the TMEM16A channel has not been determined, making it difficult to understand how the channel operates. Stephens, Marcoline, Peters, and Grabe use molecular simulations to show that the 1PBC-bound structure opens upon inhibitor removal. rupress.org/jgp/article/...

An #epilepsy-associated Kᵥ3.1 potassium channel variant acts via dominant positive effect. New study from Jerome Clatot, Ethan M. Goldberg @ethangoldberg.bsky.social and colleagues @childrensphila.bsky.social: rupress.org/jgp/article/... #IonChannels #Biophysics #Pathophysiology

Along with membrane potential and respiration, mitochondrial matrix volume is a critical parameter that is linked to physiological and pathological states. Akosah et al. present an assay for detection of the dynamic changes in mitochondrial matrix volume in living cells. rupress.org/jgp/article/...

Na/K pump α1 subunit variants cause several disease phenotypes. Colmano, Self, Artigas et al. show that all variants known to cause hypomagnesemia and seizures carry aberrant leak currents and have both reduced function and reduced plasmalemma expression. rupress.org/jgp/article/...