Glad to share our benchmark study in Genome Biology on highly variable gene (HVG) selection methods for single-cell RNA-seq. We show that a hybrid strategy performs best, now implemented in the mixhvg R package. rdcu.be/eUfjt

Zeng et al. developed a mutation-associated neoantigen (MANA) score, based on the expression of ENTPD1, CXCL13, and IL7R, that can identify neoantigen- and tumor-associated antigen-specific TILs across cancers. bit.ly/4hIhgFB   @jhubiostat.bsky.social  @jihk.bsky.social

Exciting collaboration with the Jackson, Pardoll, Yegnasubramanian, and Bettegowda Labs - now published in Science! Grateful for the contributions of our current and past group members: Runzhe Li, Zhicheng Ji, Wenpin Hou, and Wentao Zhan. #TeamScience

PennMedCSO@pennmedcso.bsky.social · 2y ago

New research from @Dr_CJackson (@PennNSG) out in @science.org identifies 14 distinct immune-suppressing cell subsets in #glioblastoma tumors, shedding light on how the tumors evade the immune system & spread ft. Kate Jones www.science.org/doi/full/10....

Thrilled to introduce FUNCODE, a new ENCODE4 resource quantifying cross-species conservation of DNA elements' dynamic activities - going beyond sequence conservation - using ENCODE data. Check out the preprint: www.biorxiv.org/content/10.1....