More on the reservoir. The AGING cohort in Argentina (defined as 50 or older!!!) looked at total DNA and pro-inflammatory cytokine profiles longitudinally over 1 year. No changes but a short follow up time. I’d be interested in following this cohort over time w longer follow up analyses #IAS2025

This #IAS2025 poster looked at the #HIV reservoir in the Rakai cohort Uganda, measured w QVOA. As we know, QVOA < total HIV DNA. Interestingly QVOA doubled over 5 years for women in the cohort pre- and post-menopause. More evidence that female sex hormones impact reservoir. IPDA data coming

Always an excellent and engaging speaker Katie Bar, #IAS2025 Track A rapporteur summarises 3 days packed with science in 14 minutes. What an amazing job! Check out the recording for a really nice overview of the basic sciences presented here in Kigali

#HIVcure in the poster hall at #IAS2035 on Thursday! Social & behavioural research done as part of FRESH cohort #ATI study in Africa. So important to include this work w the biomedical analysis. Family & partners of study participants underwent in-depth interviews - concerns raised abt risks

🕯️ 11 years ago, 298 lives were lost on #MH17, including IAS President Joep Lange & IAS Members Jacqueline van Tongeren, Pim de Kuijer, Martine de Schutter, Lucie van Mens & Glenn Thomas – on their way to #AIDS2014. We continue to honour their legacy through our work.

AGT-103-T: autologous gene modified CD4 T cells via lentiviral vectors #HIVcure clinical trial with #ATI - increased and sustained T cell expansion and on second ATI smaller viral rebound and quicker resuppression.

More from @westmeadinst.bsky.social at #IAS2025 at the cutting edge Basic Science session Josefina Marin presents on IMAP (immunoinformatic analysis pipeline) which selects peptides found within >85% Los Alamos database) - known as IMAP peptides.

So there have been a few #HIVcure clinical trials recently w dual long acting bNAbs 3bnc117+101074 -RIO: acute treated all male cohort mainly subtype B, Europe -FRESH: acute Rx, + VES, all female, SSA -Caskey study: chronic Rx + N803, USA -PAUSE: SSA majority female no bNAb sensitivity screening

CAR-T cells are hot right now in #HIVcure science. These cells can engineered to recognise HIV antigens to be used as a “shock & kill” agent. Fabulous summary of where we are at with CAR-T at #IAS2025 Currently studied in a few phase I safety clinical trials.

#IAS2025 ICHESA study looking at NK cell function in elite controller compared to non-controllers Elite controllers have distinct NK cell profiles and understanding mechanisms of immunological control in elite controllers can teach us a lot for #HIVcure

Another #HIVcure #ATI study from Southern Africa: PAUSE study a 3bnc117 & 101074 LS-J versions. bNAb screening NOT conducted pre-enrolment Primary endpoint again is viral rebound at 24w when therapeutic bNAb levels are still circulating - like RIO & Marina Caskey’s bNAb study presented yesterday

In the immunological control for #HIVcure session at #IAS2025, my friend @jespergunst.bsky.social presents beautifully about what we know & what we don’t know about predictors of post treatment control & post intervention control with a shout out to the HIV reservoirs consortium.

Poster for the FRESH cohort ATI study mentioned at the #IAS2025 #HIVcure preconference. Single arm toll like receptor agonist + 2 bNAbs w ATI in acute treated women w HIV This poster looked at VES pharmacodynamics and immune activation.

Study from Aus 🇦🇺🐨🦘 in the poster hall #IAS2025 Our friends at @westmeadinst.bsky.social looked at cells from blood & pleural effusion fluid from people w HIV w active pleural TB. TB coinfection impairs HIV specific CD8 T cells causing more genetically intact provirus in pleural effusion cells.

#HIVcure in the poster hall at #IAS2025 on Wednesday This poster from Duke Transplant Centre highlights the HOPE Act in USA: 500 transplants in PLWH receiving organ transplants from HIV+ donors. This is a rich opportunity to biobank discarded lymphoid tissue from the operation for research

#HIVcure in the poster hall on Tuesday at #IAS2025 This Thai cohort started on ART very very early in #HIV infection - Fiebig stage I-V. 5 years after brief ATI clinical and psychosocial outcomes were compared b/w those who underwent #ATI vs those who declined to do so

Gus Valen in the innovative virology section - from DIPS to TIPS. His team engineered a therapeutic from a natural process that causes viral load vascilations in plasma. Tested in monkey model - single dose TIPS led to lower viral set point. Track A #IAS2025

Joseph Eron - LEN plus 3bnc117 and 101074 (bought by Gilead and now “TAB and ZAB”). I think this was a TREATMENT study. 6 monthly dosing of LEN TAB and ZAB. 3 virological failures (but Joseph using the wording of viral rebound as if the participants underwent treatment interruption).

Zoe Stylianidou shows how her group’s hybrid CAR-T cells were able to secrete bNAbs in cell line models and also induce NK cell degranulation

Fabulous talk by Katie Bar about her team’s efforts to find complementary bNAbs that can be used together much like the work horses in the field - 3bnc117 and 101074. They’ve found some candidates and hopefully they have broader application and efficacy, particularly in non-subtype B HIV

Marina Caskey at the #bNAb session at #IAS2025: 2bNAbs - 3bnc117-LS and 10-1074-LS and N-803 (immunotherapy)

Track A session on strategies targeting the #HIV reservoir at #IAS2025! Marina Tuyishme presenting on the impact of latency reversal agents (LRAs) in blood and lymph nodes in people with and without HIV. Detailed analysis of the reservoir including transcriptomic data

#HIVcure front and centre at #IAS2025. The plenary session of Day 2 of the conference starts with an overview of immunological strategies towards an HIV cure, including an update on the San Fransisco and Esperanza exceptional elite controllers

It’s never too early in the morning to talk about #HIV transcription! The day kicks off at #IAS2025 with a session about silencing the transcriptionally active HIV reservoir and implication for #HIVcure strategies

So many powerful words from Rosemary Mburu at the opening ceremony of #IAS2025 “The path to ending the pandemic … is carried on the back of community.” “Community action is what gives science it’s soul” Powerful reminders that the #HIV response is only possible with strong community cooperation

Dr Laura Waters@drlaurajwaters.bsky.social · last yr.

Rosemary Mburu #ias2025 "Science is not just data! It is DIGNITY. Investment in people is not just nice to have, it's creating powerful agents for change. RESILIENCE MUST BE MET WITH RESPECT @iasociety.bsky.social

#IAS2025 has begun! After days of pre-conferences and symposia the conference officially starts with the opening ceremony. Standing room only in the auditorium and many in the spill over viewing rooms

We are hiring! If you are interested in infectious diseases, developing molecular diagnostics for clinical impact with wet and dry lab expertise this is the job for you! www.linkedin.com/jobs/view/42...

Final session for the #HIVcure preconference at #IAS2025 focuses entirely of cure clinical trials being done in Africa. It’s exciting to see more and more of these types of session at major HIV/AIDS conferences internationally

Back after lunch at the #IAS2025 #HIVcure preconference talking about viral diversity and how this impacts response to cure interventions.

The #HIVcure preconference at #IAS2025 continues with talks about the interplay of confections such as hepatitis B, CMV, tuberculosis and fungal components of our gut microbiome (or mycobiome!).