Data uncover a novel mechanism by which doxorubicin enhances neuroblastoma tumor susceptibility to γδT-cell–mediated killing through ULBP1 up-regulation, provides a strong rationale for combining chemotherapy with immunotherapy. Learn more: https://ow.ly/kaBX50ZvVVi.

Data suggest a significant role for CCR6-CCL20 signaling in regulating Ig isotype switching at the mucosal barrier during intestinal inflammation, thereby offering important insights into CCR6-mediated inflammatory pathologies. Learn more: https://ow.ly/3Wvr50ZvVT7

Explore the official Abstract Supplement published in The JI. An invaluable resource for catching up on the latest data, preliminary findings, and emerging trends shared by colleagues from around the globe. 🔗 https://ow.ly/2PYZ50ZuMM3.

Researchers identified a chronic critical illness after trauma is not driven by classic immunosuppression but is driven by an IL-17–skewed immune program and ineffective pathogen control. Learn more about how this could help patients: https://ow.ly/mx1Y50ZnO23.

New data underscores the role of mitochondrial health in shaping T cell functional diversity and response to immune checkpoint inhibitors, which researchers say holds insight for developing novel immunomonitoring strategies. Learn more in The JI: https://ow.ly/8mt050ZnO0r.

When determining how γδ T cells in the fetus respond to cytomegalovirus infection, researchers found that they exhibit a high degree of proliferation, activation, and memory differentiation. Read more in the new Clinical and Human Immunology Collection: https://ow.ly/UEBg50ZnNZo.

Data demonstrate that rheumatoid arthritis patients have both intrinsic differences in natural VDJ arrangements and overall B cell selection processes compared to healthy controls. Learn more in the Clinical and Human Immunology Special Collection: https://ow.ly/WP6J50ZnNVe.

A publication in the Clinical and Human Immunology special collection finds that notch signaling may contribute to long-term antigen-specific CD8+ T cell responses after mRNA vaccination. Learn more and read the whole collection in The JI: https://ow.ly/gWTS50ZnNRw.

Did you present your abstract at #IMMUNOLOGY2026? Expand your presentation by submitting a manuscript to The JI to be included in an upcoming special collection, Highlights of #IMMUNOLOGY2026™. Learn more: https://ow.ly/57wL50Zl988.

Whole-body irradiation is required for optimal CAR-T cell engraftment in mice, but irradiation can improve lupus disease, creating challenges for assessing CAR-T cell therapy. New research in The JI provides a framework to address this challenge: https://ow.ly/zgPW50ZhTkZ.

A #CuttingEdge article suggests TGFβ modulates the metabolic networks and immune signaling cascades of alveolar macrophages to control inflammatory pathways and that the role of type I IFNs is a key initial response to invading pathogens in the lungs. https://ow.ly/NWRl50ZhTkW.

Data identify NOP16 as a previously unrecognized modulator of class switch recombination, highlighting its relevance in adaptive immunity and extending its functional significance beyond cancer biology. Learn more in The JI: https://ow.ly/Mw7r50ZhTje.

Data identify a causal SNP and methylation mechanism that disrupts transcription factor binding, providing a theoretical foundation and molecular resources for disease-resistant breeding of grass carp, the most abundantly farmed freshwater fish. https://ow.ly/zfMX50ZhTiG.

New data identifies NDRG3 as a previously undescribed regulator of restimulation-induced cell death in T cells, suggesting NDRG3 as a target for autoimmune disorders and chimeric antigen receptor T cell treatment for cancer. Learn more: https://ow.ly/eLT050ZhTih.

Researchers observed a higher level of immune activation in patients with preeclampsia compared with uncomplicated pregnancies. The researchers suggest high levels of induced “memory” NK cells may play a role. Learn more: https://ow.ly/bitO50ZhTha.

Data identifies Th9 cells as contributors to endometriosis-associated immune dysregulation. Th9 cells exhibit diverse, context-dependent roles, facilitating inflammation in early disease, while contributing antiproliferative functions in later stages. https://ow.ly/7HOR50ZhTnE.

High-frequency influenza-specific CD8+ T cells with a tissue-resident phenotype that recognize conserved viral epitopes and have a functional phenotype distinct from cells found in blood were found in the lower airways during viral clearance. Read more: https://ow.ly/VH5450ZhTgV.

Researchers identified 2 healthy adult brothers lacking FcγRIIIb on neutrophils and described their neutrophil activation through FcγR engagement by opsonized Escherichia coli. Read the findings for insights into the functional relevance of FcγRIIIb: https://ow.ly/59th50ZhTfH.

Data reveal the mechanisms behind how PI3Kδ inhibition generates T cells capable of establishing and maintaining an antitumor immune response, suggesting a promising strategy for improving adoptive cell therapy outcomes in solid tumors. Read more: https://ow.ly/CVAC50ZhTnb.

A new Special Collection in The JI highlights the many roles of PI3K-δ in adaptive immunity, including a review on key milestones in knowledge of PI3K-δ, and two reviews discussing its role in B cells and T cells, respectively. Read the full collection: https://ow.ly/5F1c50ZhTep.

Porcine reproductive and respiratory syndrome virus (PRRSV) is one of the most economically important viral pathogens in the swine industry. New data increase our understanding of PRRSV pathogenesis and give clues on the development of antivirals. https://ow.ly/nSHn50ZhTmI.

New data highlight a critical role for CNS1-dependent peripherally induced Tregs in determining acute lung injury severity, providing insight into how Treg subpopulations may be harnessed to mitigate tissue damage. Learn more: https://ow.ly/nCsJ50ZhTcX.

New data support a mechanism by which IL-15 stimulates bystander memory CD8+ T cells to enter the central nervous system and contribute to injury independent of antigen-specific stimulation. Read more in The JI: https://ow.ly/mT2o50ZhTlz.

1C6 Tc1 and Tc17 cells induced experimental autoimmune encephalomyelitis upon adoptive transfer to NOD.Scid mice and data show in vivo expansion of CD4+ T cells despite 1C6 Tc cells being purified on CD8 expression prior to transfer. Learn more: https://ow.ly/heZQ50ZhTmt.

Researchers developed a systems-predicted neutralizing antibody platform that can quantify neutralization capacity at the multiplex level without requiring higher biosafety level containment. Learn more in The JI: https://ow.ly/Kfot50ZhTm5.

Data show low-intensity electroacupuncture reduces joint inflammation in collagen-induced arthritis rats, through modulation of lipoic acid metabolism and copper homeostasis, providing insight into its anti-inflammatory impact in rheumatoid arthritis. https://ow.ly/vBbz50ZhTlp.

Data indicate that within the first 15 days of life thymus-derived Foxp3+ Treg cell immunoregulation is sufficient to support the accumulation of an ever-increasing subpopulation of anergic NRP1+ CD73+ CD4+ T cells. Learn more in The JI: https://ow.ly/Ueko50ZeMs9.

Data show that ketone body β-hydroxybutyrate and multiple short-chain carboxylic acids can suppress NLRP3 inflammasome activation in acidic conditions, expanding the metabolites that can modulate this key proinflammatory pathway during energetic stress. https://ow.ly/RjZz50ZeMrr.

Data show that lupus nephritis is characterized by progressive amplification of inflammatory, fibrotic, and immune activation programs that become anatomically compartmentalized within the kidney. Read how these data could direct new interventions: https://ow.ly/nipc50ZeMqC.

Data demonstrate that Ets1 is a positive regulator of germinal center Tfh cell differentiation and function during viral infection, highlighting a context-dependent role for Ets1 in GC Tfh cell responses. Learn more: https://ow.ly/MZuY50ZeMq2.