🆕 in JMCC: snRNA-seq identifies the FN1-SDC4 axis as a driver of epicardial activation in pulmonary hypertension. Epicardial Sdc4 knockdown limits right ventricular remodeling, highlighting a potential therapeutic target 🎯 www.jmcc-online.com/article/S002...

🆕 in JMCC: PAI-1 deficiency drives sex-specific cardiac fibrosis after stress. Metformin reduces fibrosis and improves cardiac function in a sex- and stressor-dependent manner, with marked protection in females after AngII ♀️ www.jmcc-online.com/article/S002...

🆕 in JMCC: The deubiquitinase OTUD5 promotes pathological cardiac hypertrophy by stabilizing TRAF2 and activating NF-κB and AKT/GSK3β signaling, identifying the OTUD5-TRAF2 axis as a potential therapeutic target🎯 www.jmcc-online.com/article/S002...

🚨 New in JMCC: A KCNH2 mutation alters L-type Ca²⁺ current gating in LQT2 cardiomyocytes. Estradiol corrects key Ca²⁺ current defects and shortens repolarization, yet may paradoxically preserve susceptibility to early afterdepolarizations⚡️ www.jmcc-online.com/article/S002...

🆕 in JMCC: In vivo phosphoproteomics maps EGF- and NRG1β-driven ErbB signaling in the adult heart, revealing shared and ligand-specific networks spanning insulin signaling, Ca²⁺ handling, metabolism, and sarcomere regulation🫀 www.jmcc-online.com/article/S002...

🆕 in JMCC: SK channels become functionally active early in human ventricular remodeling despite unchanged expression. Their recruitment depends on Ca²⁺ handling and CaMKII signaling, with implications for SK-targeted AF therapies 💊 www.jmcc-online.com/article/S002...

🆕 in JMCC: Low-dose melatonin promotes coronary angiogenesis and improves cardiac function after MI by targeting endothelial LRRC8A and activating AKT/eNOS/HIF1α signaling, revealing a potential strategy for ischemic heart disease 🫀 www.jmcc-online.com/article/S002...

🚨 New in JMCC: This Letter to the Editor shows that dietary BCAA availability modifies exercise-induced cardiac growth in male mice, while improved exercise capacity can occur independently of cardiac growth in both sexes ♀️ ♂️ www.jmcc-online.com/article/S002...

🚨 New in JMCC: The C-terminal peptide of cardiac troponin T binds the thin filament and reduces Ca²⁺ sensitivity, while HCM mutations disrupt these effects, revealing a potential strategy to correct myocardial hyperactivation 💪🏼 www.jmcc-online.com/article/S002...

🆕 in JMCC: Quercetin improves cardiac redox balance and antioxidant defenses in diabetic rats but fails to restore mitochondrial respiration, suggesting antioxidant therapy alone may not reverse T2DM-related cardiac bioenergetic dysfunction ⚡️ www.jmcc-online.com/article/S002...

🚨 Please join us for our next ISHR MCI Seminar on Wednesday, September 9 featuring Drs Mingtao Zhao and John Calvert, who will share their latest research🔬🧬🫀 Register today and save your spot! us02web.zoom.us/webinar/regi...

⭐ Editor's Choice | 🆕 in JMCC: This study uncovers a stepwise mechanism of enhancer activation in plastic vascular smooth muscle cells, revealing how H2A.Z-driven enhancer maturation shapes cell plasticity and vascular remodeling throughout adult life. www.jmcc-online.com/article/S002...

🆕 in JMCC: Enhancing mitochondrial SK channels restores mitochondrial Ca²⁺ and redox homeostasis, suppresses pro-arrhythmic Ca²⁺ release, and rescues Ca²⁺ cycling in HFpEF cardiomyocytes, highlighting a promising antiarrhythmic strategy⚡️ www.jmcc-online.com/article/S002...

🚨 New in JMCC: This review highlights how single-cell multi-omics and computational approaches are transforming our understanding of cardiac aging, revealing cell type-specific remodeling and new therapeutic targets in aging hearts 💊 ❤️‍🩹 www.jmcc-online.com/article/S002...

🆕 in JMCC: L-menthol protects cardiomyocytes from lipid overload by preserving TRPM8 signaling, mitochondrial Ca²⁺ homeostasis, and mitochondrial function. Stabilizing TRPM8 may represent a new therapeutic strategy for metabolic heart disease🫀 www.jmcc-online.com/article/S002...

🚨 New in JMCC: Integrated single-cell multi-omics identifies fibroblast-like smooth muscle cells as a progenitor-like population driving aortic aneurysm progression through a KAT5-mediated metabolism-epigenetic axis regulating phenotypic switching 🧬 www.jmcc-online.com/article/S002...

🆕 in JMCC: A CRISPR-generated non-phosphorylatable phospholamban (PLB) mouse model reveals that PLB phosphorylation is essential for a full adrenergic response, preserving SR Ca²⁺ load, Ca²⁺ reuptake, and excitation-contraction coupling ⚡️ www.jmcc-online.com/article/S002...

New in JMCC! Zu and colleagues uncover the functional divergence of hoxb5 paralogues, identifying hoxb5a as the dominant regulator of cardiac morphogenesis and calcium handling in vertebrate heart development. www.jmcc-online.com/article/S002...

Evolutionary differentiation of duplicated hoxb5 paralogs orchestrates calcium signaling and contractility

hox genes are evolutionarily conserved transcription factors essential for anterior–posterior body patterning, yet their specific contributions to cardiac morphogenesis and calcium signaling remain…

jmcc-online.com

New in JMCC! Phosphorylation of βIII-tubulin at Ser172 restores microtubule network organization and protects against arrhythmias and cardiac fibrosis in Duchenne muscular dystrophy cardiomyopathy. www.jmcc-online.com/article/S002...

Phospho-mimic βIII-tubulin rescues microtubule and cardiac defects in Duchenne muscular dystrophy mice

Duchenne muscular dystrophy (DMD) cardiomyopathy is caused by mutations in the dystrophin gene and characterized by profound cytoskeletal disorganization, particularly pathological remodeling of the…

jmcc-online.com

New in JMCC! A five small molecule cocktail (5SM) promotes cardiac regeneration post-MI via activation of the DYRK1B–PKA–CREB–TGFβ/BMP signaling axis. www.jmcc-online.com/article/S002...

Small-molecule cocktail 5SM induces heart regeneration by upregulating TGFβ/BMP signaling

Zebrafish and neonatal mammals possess a remarkable capacity for cardiac regeneration following injury, a property that is largely absent in adult mammals. We have recently identified a cocktail of…

jmcc-online.com

New in JMCC! Transient expression of OCT4, SOX2, and KLF4 enhances post-MI cardiac regeneration by promoting cardiomyocyte dedifferentiation. www.jmcc-online.com/article/S002...

OSK-mediated partial reprogramming induces cardiomyocyte dedifferentiation, overcomes cytokinesis barriers, and promotes post-MI endogenous cardiac regeneration

Myocardial infarction (MI) leads to irreversible loss of cardiomyocytes (CMs), owing to the limited regenerative capacity of the adult mammalian heart. Previous studies indicate that the Yamanaka…

jmcc-online.com

New in JMCC! This review provides an overview of the mechanisms linking metabolic syndrome to cardiovascular disease and emerging therapeutic strategies to reduce cardiovascular risk. www.jmcc-online.com/article/S002...

Pathophysiology and pharmacotherapy of cardiovascular complications in metabolic syndrome

Metabolic syndrome (MetS) symbolises a cluster of interrelated risk factors including central obesity, dyslipidemia, insulin resistance and hypertension, those significantly increase the risk of…

jmcc-online.com

New in JMCC! Lycorine hydrochloride attenuates neointimal hyperplasia and suppresses PDGF-BB-induced vascular smooth muscle cell phenotypic switching via a MAPK-dependent mechanism. www.jmcc-online.com/article/S002...

Lycorine hydrochloride reveals a novel role in preventing neointimal hyperplasia through MAPK-mediated phenotypic switching of smooth muscle cells

Neointimal hyperplasia results from irregular vascular smooth muscle cell (VSMC) proliferation and migration. Lycorine hydrochloride (LH), known for its cardioprotective properties, was investigated…

jmcc-online.com

New in JMCC! Contrary to preclinical models, JPH2 protein abundance is not reduced in failing human hearts despite significant T-tubule remodeling, highlighting the need for human tissue-based validation of candidate therapeutic targets. www.jmcc-online.com/article/S002...

Junctophilin-2 abundance is unaltered in human heart failure samples with disrupted T-tubules and contractility

T-tubules are structural components of the cardiomyocyte plasma membrane that are imperative for efficient excitation-contraction coupling and cardiac contraction. Junctophilin-2 (JPH2) has been…

jmcc-online.com

🆕in JMCC: Peroxisomes are critical regulators of lipid metabolism, redox balance, & cellular homeostasis, yet their roles in the 🫀 remain underexplored. This review by Rungreang et al highlights emerging evidence linking peroxisomes to cardiac health and disease www.jmcc-online.com/article/S002...

🆕 in JMCC: Roman et al. uncover a mechanism underlying sex differences in cardiac ischemia/reperfusion injury. Increased S-nitrosylation of MCU in female hearts limits mitochondrial calcium accumulation during ischemia♀️♂️🫀 www.jmcc-online.com/article/S002...

🆕 in JMCC: Zhou et al. reveal strikingly similar metabolic signatures in human end-stage ischemic and nonischemic cardiomyopathy. Both exhibit altered amino acid metabolism, oxidative stress, purine breakdown, and depleted glutathione ⚡️🫀 www.jmcc-online.com/article/S002...

🆕 in JMCC: Liu et al. identify hematopoietic PI3Kγ as a key driver of abdominal aortic aneurysm progression. PI3Kγ promotes macrophage trafficking, aortic inflammation, and aneurysm growth, highlighting a potential therapeutic target 🎯 www.jmcc-online.com/article/S002...

🚨 New in JMCC: Jiang et al. identify the CYLD-RIPK1 axis as a key regulator of DNA damage and pathological cardiac hypertrophy. Targeting CYLD attenuated remodeling and preserved cardiac function in pressure-overloaded hearts 🎯 www.jmcc-online.com/article/S002...

🆕 in JMCC: Bacchini et al. show that aging and cardiomyopathy jointly reshape unfolded protein response pathways, highlighting defective proteostasis as a key contributor to myocardial dysfunction and heart failure 👴🏼👵🏼🫀 www.jmcc-online.com/article/S002...