First Bluesky post for my new preprint! Super fun project with guidance from @abbybuch.bsky.social and @willowcoyote.bsky.social. We applied saturation mutagenesis to the Lamin A protein in #hiPSC derived cardiac cells to uncover cell type-specific mutation effects 1/ www.biorxiv.org/content/10.6...

Cardiomyocyte vulnerability to lamin polymer disruption revealed by saturation mutagenesis

Hundreds of mutations to the broadly expressed LMNA gene cause disease primarily within cardiac, muscular, and adipose tissues (1). Tissue-specific pathogenesis arises when mutant protein dysfunction ...

biorxiv.org

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