Journal of Neuroimmunology
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Official Journal of Neuroimmunology News Twitter. Latest articles on Immune & Brain interface research. Fellow @JNI_Journal for latest research news
MS relapses are associated with marked but partially reversible oxidative stress. Multiple oxidative biomarkers were ⬆️ during relapse and ⬇️ after recovery, supporting redox imbalance as a hallmark of acute MS activity. ##MSResearch #Neurology sciencedirect.com/science/articl…
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Positive #MOG antibodies and steroid responsiveness don’t always tell the full story. This case of concurrent #MOGAD and spinal AVM highlights the importance of vascular imaging when presumed #myelitis recovery is incomplete. #Neurology #MOGAD #Neuroimmunology Paper 👇
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mmune-checkpoint-inhibitors related CNS #neurotoxicity can mimic paraneoplastic and autoimmune encephalitis, making diagnosis challenging. High-risk anti-neuronal antibodies may predict poorer outcomes, while post-ICI meningoencephalitis responds well to corticosteroids. 👇👇
IRE1α/ASK1 signaling drives ER stress–mediated neuronal 🧠 apoptosis via the p38-CHOP pathway and caspase-3 activation.❌Blocking this pathway 😘➡️reduced infarct size & neurological damage: a promising therapeutic target for stroke. Check out the paper 👇 www.sciencedirect.com/science/arti...
Ischemic stroke induced neuronal apoptosis via IRE1α/ASK1 signaling in mice
Neuronal apoptosis mediated by endoplasmic reticulum (ER) stress exerts crucial pathophysiological functions in the central nervous system. Inositol-r…
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High/moderate-efficacy DMTs cut sNfL ~40% and are associated with bigger gains in disability & relapse reduction; compared to first-line therapies. sNfL decline tracks EDSS/motor improvement (age-independent), but not psychiatric outcomes → biomarker potential. Paper below ⬇️⬇️
Tracking the invisible: Impact of disease-modifying therapies on serum neurofilament light chain and clinical outcomes in treatment-naïve multiple sclerosis
Disease-modifying therapies (DMTs) are widely used to manage multiple sclerosis (MS), but their effects on serum neurofilament light chain (sNfL), par…
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Persistent CNS inflammation in HIV continues despite ART. ↑ MMP-2 & MMP-9 in CSF point to localized brain inflammation. No differences across HIV subtypes or Tat variants. #HIV #NeuroHIV Check the paper below 👇 www.sciencedirect.com/science/arti...
Metalloproteinase imbalance in HIV-1: Subtype comparison in CSF and serum
Persistent central nervous system (CNS) inflammation, driven by ongoing HIV replication in the CNS reservoir despite antiretroviral therapy (ART), con…
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1 in 5 neurosarcoidosis exhibit comorbid autoimmune disease, family history of autoimmunity, or nonspecific autoantibody seropositivity. These overlapping features represent potential sources of diagnostic ambiguity and may impact treatment strategies. Check the paper below 👇
Systemic and neurologic autoimmune disorders and antibody seropositivity associated with neurosarcoidosis
Comorbid autoimmune disorders and non-specific antibody seropositivity have been commonly reported in prior studies of systemic rheumatologic disorder…
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FoxF2, a key regulator in remyelination in progressive MS 🧠 FoxF2+ Astrocyte links to TGFβ signaling and coordinates myelin repair, immune response, and metabolism. Its loss disrupts regenerative gene networks. #MultipleSclerosis #Neuroscience Check out the paper below 👇
Astrocyte-specific FoxF2 modulates immune and myelin repair: Evidence from multiple sclerosis lesions and an animal model
As multiple sclerosis (MS) progresses, myelin repair becomes inefficient. To gain insight into the underlying causes, we RNA-sequenced postmortem brai…
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Soluble c-Met ↑ in CSF & plasma, CSF c-Met links to NfL/GFAP, plasma ADAM10 ↓. Suggests compartment-specific c-Met shedding in early MS. #MultipleSclerosis #Biomarkers #Neuroinflammation Check the paper👇: www.sciencedirect.com/science/arti...
Soluble c-Met correlates with NfL and GFAP levels in the CSF of patients with multiple sclerosis
The hepatocyte growth factor (HGF)/c-Met pathway plays an important role in several inflammatory conditions, regulating phenotypic plasticity within b…
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🧠👶🏻 Upcoming release of a special issue dedicated to Pediatric Neuroimmunology. Call for paper, check details below and submit your work: sciencedirect.com/special-issue/…
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🧠🦠 Open Call: Gut–Brain Axis Special Issue Exploring microbiome and CNS communication & translational insights. Submit your work 👉 www.sciencedirect.com/special-issu... #GutBrainAxis #Microbiome #CallForPapers
Journal of Neuroimmunology | Gut-brain axis | ScienceDirect.com by Elsevier
The bidirectional communication between the gastrointestinal tract and the central nervous system—the gut–brain axis—has emerged as a dynamic area of biomedical research with profound implications for...
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An inspiring Welcome & Kenneth P. Johnson Memorial Lecture #ACTRIMS2026, beautifully presented by Chair Dr. Danny Reich. Moments like these remind us why academic community matters
Largest genetic study to date: the MTHFR C677T variant is associated with a 9% lower risk of multiple sclerosis, with no impact on disease severity 🧬 #MultipleSclerosis #genetics #cureMS Check out the paper below 👇 www.jni-journal.com/article/S016...
Genetically reduced MTHFR activity confers protection against multiple sclerosis
Methylenetetrahydrofolate reductase (MTHFR) generates the active form of folate required for homocysteine metabolism. The C677T variant in MTHFR reduces enzymatic activity, increases homocysteine leve...
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Diagnosing neurologic irAEs from ICIs is challenging. MRI is key to ruling out cancer spread and detecting indirect signs of neuroinflammation. This review 👇 highlights the essential imaging and diagnostic features of ICI-related neurotoxicities. www.jni-journal.com/article/S016...
Neurological adverse events of immune checkpoint inhibitors: A practical guide to diagnosis with a focus on neuroimaging findings
The use of immune checkpoint inhibitors (ICIs), a class of oncologic therapies that enhance anti-tumor immunity, may be complicated by the occurrence of neurologic immune-related adverse events (n-irA...
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Updated flow cytometric MOG-Ab cut-offs aligned with 2023 MOGAD criteria: Clear-positive: 90.7% PPV, in core demyelinating events: 100% PPV, High clear-positive: 100% specificity (lower sensitivity) MOGAD diagnosis accuracy in Korea. #MOGAD #Neuroimmunology Paper below 👇
Clear-positive cut off determination of flow cytometric MOG-antibody assay in Korea: Alignment with international MOGAD diagnostic standards
MOG-Ab assay is a sensitive and specific biomarker that is indispensable in diagnosis of MOG antibody-associated disease (MOGAD). However, its accuracy can largely depend on a proper selection of pati...
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Acupuncture eases neuropathic pain in lumbar disc herniation by blocking the CXCL12/CXCR4–ERK/NF-κB pathway, reducing glial activation and inflammation. #Neuroscience #PainResearch #Acupuncture Check the paper 👇 www.jni-journal.com/article/S016...
Acupuncture mitigates sciatic neuropathic pain in lumbar disc herniation via inhibiting spinal CXCL12/CXCR4-driven glial activation and neuroinflammation
Lumbar disc herniation (LDH) is a prevalent degenerative spinal disorder causing chronic low back pain and sciatica through persistent neuroinflammation and central sensitization. Increasing evidence ...
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Hydrogen sulfide (H₂S) protects the brain from sepsis-induced injury by boosting HO-1 and blocking HMGB1. In mice, H₂S improved survival, cognition, and reduced brain damage - a potential therapy for sepsis-related injury. #Sepsis #Neuroinflam #H2S #HO1 #HMGB1 Paper 👇
Hydrogen sulfide (H₂S) ameliorates sepsis-induced brain injury by upregulating heme oxygenase-1 (HO-1) to inhibit high-mobility group box 1 (HMGB1) release
The incidence of brain injury in sepsis patients has been as high as 70 %, which has been a significant cause of septic patients' death. However, the pathophysiology of brain injury in sepsis is multi...
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Neoehrlichiosis, an emerging, underdiagnosed tick-borne infection. B-cell–depleting therapy increases risk and severity. #MS patients with fever, high CRP, or anemia may need further attention prior treatment initiation. #InfectiousDisease #MS #Neoehrlichiosis Paper below 👇
Neoehrlichiosis in patients with multiple sclerosis in Halmstad, Sweden: A case series
Neoehrlichiosis is an emerging tick-borne infection. The documented cases of human infection demonstrate a varying symptomatology, diagnostic difficulties, a lacking clinical awareness of the conditio...
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Fast-forward through our day in neuroimmunology 🔬 — where every pipette move brings us closer to the next discovery. #Neuroimmunology #LabWork #DataGeneration #PaperPrep #Pipetting #StainingHumanCells
Insight into stroke recovery! miR-126 worsens brain injury by suppressing LRP6 in the Wnt/β-catenin pathway. Blocking it restores signaling, reduces cell death, and improves outcomes - a promising new stroke therapy target. #StrokeResearch ##miR126 #WntPathway Check the paper 👇
Inhibition of microRNA-126-3p attenuates ischemic stroke by targeting endogenous neuroprotective receptor LRP6 in the Wnt/β-catenin signaling pathway
MicroRNA-126 (miR-126) has emerged as a potential key regulator in ischemic stroke. Yet, its exact mechanism of action is still unexplored. This study aims to investigate whether miR-126 targets and r...
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It was an honor to sponsor the ISNI Young Session, Symposium 22 at #ISNI2025 in Chiba! 🌏 Congrats to our winner, @rosadelegadojimenez, and all speakers! Special thanks to @HeinzWeindl for making this session a success! 🙏 #Neuroimmunology #ISNI2025 #NextGenerationScientists
Hypoglycorrhachia shapes the landscape of encephalitis. Low CSF/serum glucose flags infectious causes, while its absence points to autoimmune disease with higher ICU burden. #NeuroID #Encephalitis #Neuroimmunology Check the paper below 👇 www.jni-journal.com/article/S016...
The role of hypoglycorrhachia as a cerebrospinal fluid to serum glucose ratio in adults with encephalitis
We aimed to determine the clinical and prognostic significance of hypoglycorrhachia in adults with encephalitis.
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CAR-T therapy has transformed hematologic cancers, but ICANS remains a major barrier. Diverse neurotoxicities, lack of biomarkers, and unclear mechanisms highlight an urgent unmet need. #CART #Neurotoxicity #crackingICANS Check out the paper below 👇 www.jni-journal.com/article/S016...
Neurotoxicity associated with chimeric antigen receptor T-cell therapy
Chimeric antigen receptor T cell (CAR-T) therapy involves reengineering patient-derived or donor-derived T cells to express a synthetic CAR that can recognise specific cell-surface antigens, independe...
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⏰ Starting soon Join this webinar to hear tips and strategies to promote your recently accepted or published work. @jnijournal.bsky.social Register now: https://neuronline.sfn.org/professional-development/communication-and-recognition
Join us at #ISNI international congress 5-8 October in Chiba, Japan. We are supporting the young investigator session.
Beyond the brain: Our review explores how peripheral monocyte-derived macrophages (MDMs) shape Alzheimer’s disease pathogenesis—revealing new therapeutic opportunities outside the blood-brain barrier. 🧠🧬 #Alzheimers #Neuroimmunology Check out the review below 👇 www.jni-journal.com/article/S016...
The immune response within Alzheimer's disease: from the lense of peripheral monocyte-derived macrophages
Alzheimer's disease (AD) is the most significant form of dementia characterized by neurodegeneration and higher-order cognitive decline affecting over 6.9 million Americans age 65 and older. Emerging ...
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First reported case of AQP4+ NMOSD after golimumab for ulcerative colitis, presenting with intractable hiccups (Area Postrema Syndrome). Managed with plasmapheresis + rituximab, partial improvement. Check out the paper 👇 www.jni-journal.com/article/S016...
When gut and nerves collide: A case of Neuromyelitis Optica Spectrum disorder after golimumab for ulcerative colitis
Anti-TNF alpha agents, such as golimumab, are effective treatment options for moderate to severe inflammatory bowel disease. However, demyelinating syndromes have been reported as rare adverse events....
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Autoimmune nodopathies mimic seronegative GBS or CIDP but have distinct biology and treatment response — often failing IVIg or steroids, yet improving with anti-CD20 therapy. Early recognition can be life-changing. #Neurology #RareDisease Check out this paper 👇 www.jni-journal.com/article/S016...
The immunology and neuropathology of the autoimmune nodopathies
The autoimmune nodopthies have recently emerged as a discrete subtype of inflammatory neuropathy. They are characterised by the presence of IgG class autoantibodies directed against structural compone...
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We’re excited to announce the Young Investigators Special Issue in the Journal of Neuroimmunology! We will spotlight early-career researchers and support the next generation of discovery. Submit your original research and let your work be seen and recognized. #CallForPaper
Journal of Neuroimmunology | Early career investigators in Neuroimmunology | ScienceDirect.com by Elsevier
Historically, many established investigators in the field of neuroimmunology published early work from their laboratories in the Journal of Neuroimmunology. Our mission is to bring important work in t...
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CSF cell analysis is key to understanding neurological diseases but has been limited by cell fragility. Millet Wallisky et al. introduce a rapid, one-step method for efficient CSF immune profiling Check out the paper below 👇 www.jni-journal.com/article/S016...
Rapid one-step protocol for exploring immune cells in cerebrospinal fluid
Flow cytometry analysis of the cerebrospinal fluid's immune cell subset profiles can be used to help in the diagnosis and prognosis of nervous system pathologies. However, the cells need to be analyze...
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