New preprint! How does a cell "know" how big to make its nucleus? This has puzzled biologists since the 1800’s. We show the answer is physics: colloid osmotic pressure. 🧵1/5

bioRxiv Biophysics@biorxiv-biophys.bsky.social · 3mo ago

Nuclear size and physical properties of the nucleoplasm are determined by colloid osmotic pressure at the nuclear envelope https://www.biorxiv.org/content/10.64898/2026.07.21.739918v1

The nucleolus is the largest condensate in the nucleus and the site where ribosomes are built. It has no membrane. It assembles by phase separation, components demixing from the nucleoplasm into a droplet. So what decides when it forms? 🧵🪱💧 www.biorxiv.org/content/10.6...

www.biorxiv.org/content/10.6...

Tolerance to the antifungal drug fluconazole is mediated by tuning cytoplasmic fluidity

Treatment failure rates for fungal infections cannot be explained simply by increased rates of drug resistance. Antifungal drug tolerance, the ability of a susceptible isolate to grow in the presence ...

biorxiv.org

My former bench mate @joellemiere.bsky.social from the @fredchanglab.bsky.social giving a killer talk about nuclear size regulation in fission yeast at #ASCB #CellBio2025 Stay tuned for the paper to come soon ! Beautiful experimental data falling on the mathematical model, no fit needed 🤩

We have a new preprint! 👉 We’ve developed a novel method to induce spindle buckling and utilize this deformation to gain insights into their structural integrity. 👉 A little animated illustration on the bent spindles (green) and our model (blue+pink) where we tune the rigidity of the midzone.

bioRxiv Cell Biology@biorxiv-cellbio.bsky.social · 11mo ago

Analyses of bent spindles reveal the mechanics of anaphase B in fission yeast https://www.biorxiv.org/content/10.1101/2025.11.20.689516v1

Save the date for the 3rd edition of the Physics & Life days, division of the French Physical Society, October 2-3 at the Institute Jacques Monod, Paris. More info coming soon! Co-organised with Silvia Grigolon & Morgan Chabanon. @sfp-physique.bsky.social @ijmonod.bsky.social

French Senator Claude Malhuret: "Washington has become Nero’s court, with an incendiary emperor, submissive courtiers and a jester high on ketamine... We were at war with a dictator, we are now at war with a dictator backed by a traitor."

Our lab has multiple open positions for post-docs to study the regulation and function of cytoplasm mechanics during embryo development. Details below 👇👇 Please Repost !!! @ijmonod.bsky.social @cnrs.bsky.social