John Parkhill
@johnparkhill.bsky.social
Senior director of machine learning @ Terray Therapeutics (https://www.terraytx.com/). Father. NSF CAREER award giver-upper. Gibe and gambol enjoyer. Refugee from https://x.com/j0hnparkhill. http://bbgky.net
Generative chemistry requires fast (~ms / molecule / GPU) and accurate retrosynthesis. Miles and Zach did a really good job with this: www.terraytx.ai/news-and-res...
TerraSynth - Terray Therapeutics
Built at the Intersection of AI and Experimentation
terraytx.ai
-- Hiring ML Engineers time! -- Are you a smart person who wants to make therapeutics to help people using your ML chops? We will hire two engineers. We don't care about your pedigree, just your skills. Prove them by attempting the exercise linked below (<6 hours)
164.92.115.7
As illustrated every damn day in this wannabe administration.
Norm DePlume@normdeplume.bsky.social · 6mo agoHannah Arendt did not mince words, did she? 'Totalitarianism replaces all first-rate talents with crackpots and fools whose lack of intelligence and creativity is still the best guarantee of their loyalty.' From "The Origins of Totalitarianism" (1951)
Getting a 6mo lead in reading papers pre arxiv : priceless. Hilarious ppl are just taking the motivations for this naively. openai.com/prism/
Prism | A free, LaTeX-native workspace for scientists
Write, edit, and collaborate on scientific documents in LaTeX with Prism—a free workspace integrating GPT-5.2 into research and writing.
openai.com
These are the chipotle slop bowl of science. -- Me at lunchtime.
Carb free sweetened beef is the telelogical endpoint of American civilization, and that goal is in sight. arxiv.org/abs/2601.145...
De novo design of protein binders targeting the human sweet taste receptor as potential sweet proteins
Excessive consumption of dietary sugars is a major contributor to metabolic disorders, driving global interest in finding alternative sweeteners with reduced caloric impact. Natural sweet proteins, su...
arxiv.org
It's 16 years after citizens united. If you want to resist the government what you do is sell US stock, treasuries and buy gold, and foreign stock. (really)
If you've actually managed to avoid holiday sickness by shifting hemispheres with your family this winter or sequestering. I wanna hear from you. HOW DID YOU DO IT.
It's basically impossible that Chat bot Ads will remain passive, because any competitor can do the agentic ads, and they will have a margin that is hundreds of times larger.
It's sade's birthday -- The real valentine's day for those who celebrate.
This is the way arxiv.org/abs/2506.044...
Multiscale guidance of AlphaFold3 with heterogeneous cryo-EM data
Protein structure prediction models are now capable of generating accurate 3D structural hypotheses from sequence alone. However, they routinely fail to capture the conformational diversity of dynamic...
arxiv.org
I can't decide how I feel about someone vibecoding what is asked for in the job description. It shows initiative? But probably should have added "oh, don't put vibecode emoji's everywhere" to the system prompt.
The persistence of docking in drug design has been explained. :P www.nature.com/articles/s41...
Using an algorithmic approach to shape human decision-making through attraction to patterns - Nature Communications
Here, using data from a competition between academic teams to influence decision-making, the authors show that people, intending to maximize their profit, prefer options delivering rewards in a discov...
nature.com
gemini is pretty good at making manim animations with a little help, but boy without UV, manim would be impossible to install.
If you think we can avoid Thalidomide like outcomes without animal models today, you're an idiot. If you think you're merely marketing, you should appreciate that idiots will listen to you, and the consequences will be real. I will bet anyone 1000$ if this happens it ends poorly.
The transition between "wins nobel prize" and "says vitamin C cures mortality" or "HIV doesn't cause AIDS" or "lobotomies for everyone" or "eugenics is cool" - or "disease is over because I interpolated crystal structures" is crazy short. (all utterances of nobel prize winners)
Only someone who can't think at 2nd order would ever take virtual cell models seriously without many unrelated breakthroughs. There are obvious, indisputable reasons they are stupid, and no one needs them more than me.
Anshul Kundaje@anshulkundaje.bsky.social · last yr.genomebiology.biomedcentral.com/articles/10.... Quite an indictment of some of the current single cell "virtual cell" foundation models. Even for the relatively mundane applications, cell labeling, batch correction etc, they are poor compared to much simpler & cheaper methods.
If your field is getting more "perspectives" papers or "position" papers, you're going to get feudalism and dreck. I'd hop :)
"give it to god"-- god of course being the transformer.
William Gibson owes it to the world to do another neuromancer, but where it's just descriptions of how lame the real person or prompt is behind every high follower X shitpost account. Instead of the real sexual content, dms with e-girls. Coin swindles making 5k instead of heists
If universities don't stand up to the "dark enlightenment" they will lose all their relevance.
The New York Times@nytimes.com · last yr.Breaking News: Harvard rejected the Trump administration’s demands, including that it submit to monitoring and reduce the power of faculty and students.
The amount of disrespect one has for other people's thoughts, is often crazily proportional to how desperately one craves approval and validation. It's a joke embedded in humanity.
Imagine getting ratio'd by a guy with half your rizz on your own crappy propaganda platform 😂
