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Journal of Orthopaedic Research®

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JOR, a publication of @orssociety.bsky.social, is the forum for rapid publication of high quality reports of new information on the full spectrum of orthopaedic research. https://onlinelibrary.wiley.com/journal/1554527x?journalRedirectCheck=true

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Journal of Orthopaedic Research®@jorthopres.bsky.social · 7mo ago

José L. M. Thiesen & coauthors present their findings on the effects of fracture level, screw configuration, and nail-canal clearance on load transfer in intramedullary tibial nailing: onlinelibrary.wiley.com/doi/10.1002/...

$Eight tibial fracture sites modeled for subsequent finite element analysis. From left to right we have considered fracture sites of 240, 220, 200, 180, 160, 140, 120, and 100 mm proximal to the medial malleolus. The numbers on the top indicate the fracture level from 8 (proximal fracture) to 1 (distal fracture).$

Journal of Orthopaedic Research®@jorthopres.bsky.social · 7mo ago

Check out recent special-issue article "Screw Placement Influence on Implant Stability and Osseointegration Potential in Revision Hip Arthroplasty Involving Acetabular Defects: A Cohort-Based Modeling Study", by Daniel Hopkins & coauthors: onlinelibrary.wiley.com/doi/10.1002/...

Flow diagram illustrating the automated virtual clinical trials modeling pipeline including neural network segmentation from preoperative CT images (A), 3D model generation of remaining pelvic bone from neural network segmentation (B), statistical shape model-generated pre-defect native pelvis creation from defect pelvic bone models (C), ray casting (D), point cloud generation of missing acetabular defect bone remove from ray casting (E), AlphaShape creation of acetabular defect (F), acetabular defect model generation after mesh boolean operations (G), acetabular defect model creation after regional definition (H), acetabular anatomical regional delineation (I). Color codes: sky blue – superior region, yellow – posterior region, dark blue – anterior region, green – medial wall region [16].

Journal of Orthopaedic Research®@jorthopres.bsky.social · 7mo ago

Alexander Jahnke & coauthors demonstrate the feasibility of intraoperative acoustic monitoring as a real-time, objective tool to enhance implant safety and detect cortical compromise at an early stage, before clinical manifestation: onlinelibrary.wiley.com/doi/10.1002/...

Loose versus fit. Mean ± SD spectra (green = loose, blue = fit) with red-shaded frequency clusters indicating significant differences. The lower panel displays |T|, where elevated values denote stronger group separation within the highlighted clusters. Significant clusters: 0–300 Hz, 600–900 Hz, 1100–1400 Hz, 1700–2000 Hz, 2000–2300 Hz, 3000–3400 Hz, 8700–9400 Hz, 9900–10,400 Hz, 10,500–10,700 Hz.

Journal of Orthopaedic Research®@jorthopres.bsky.social · 7mo ago

Jack Consolini & coauthors found that multi-spectral-MRI based radiomic features can classify the qualitative diagnosis of implant loosening in patients with total hip arthroplasty: onlinelibrary.wiley.com/doi/10.1002/...

Representative segmented trabecular bone compartments and THA surfaces for three subjects with THA. A variation in volume of Gruen zone 8 (anterior, shown in yellow), is noted for three subjects. A classification model could not be generated for Gruen zone 8 when the bone volume was below 2 cm3 as it prevented the generation of sufficient patches necessary for model creation.

Journal of Orthopaedic Research®@jorthopres.bsky.social · 7mo ago

Nicole A. Chittim & coauthors showed that ciprofloxacin treatment in mice causes structural & biological phenotypes commonly associated with fluoroquinolone-induced tendinopathy: onlinelibrary.wiley.com/doi/10.1002/...

Systemic ciprofloxacin treatment results in altered ECM transcriptome in tail tendons and histological changes in patellar tendon ECM. (A) Normalized transcripts of ECM-related genes from RNA sequencing data. Sorted by anabolic (fibrillar and proteoglycan) and catabolic genes. (B) Representative images of H&E staining of control (left) and ciprofloxacin-treated (right) patellar tendon midsubstance region. (C) Quantification of cell morphology as calculated by percentage of elongated cells to total cells. (D) Analysis of collagen fiber crimp as calculated by total fiber length following the curves of the fiber divided by end-to-end length. (E) Representative images of Picrosirius red (PSR) staining under polarized light of control (left) and ciprofloxacin-treated (right) patellar tendon midsubstance region. (F) Quantification of collagen fiber thickness, calculated by separating the colors from PSR images, with red being thickest fiber and green being thinnest. Bars indicate average ± standard deviation. (G) Quantification of collagen area density. (H) Representative images of Alcian blue staining of control (left) and ciprofloxacin-treated (right) patellar tendon midsubstance region. (I) Quantification of proteoglycan density from Alcian blue images. (J) Sulphated GAG content quantified from DMMB assay. Scale bars are 200 μm. Violin plots show the distribution of the data with the median, first and third quartiles highlighted. Each dot represents an average from 5 to 10 histological sections, n = 2–4 mice. Statistical analysis done with unpaired t-test. p-values and Cohen's d estimated effect size are displayed.

Journal of Orthopaedic Research®@jorthopres.bsky.social · 7mo ago

Check out this recent special-issue article, "Frontiers in the Management of Orthopaedic Periprosthetic Joint Infection", by Michael F. Shannon & coauthors:

onlinelibrary.wiley.com

Journal of Orthopaedic Research®@jorthopres.bsky.social · 7mo ago

Ahmadreza Nezameslami & coauthors investigated the friction characteristics of a manufactured tendon lubricant, providing information about a potential future human treatment for preventing tendon adhesion after tendon surgery: onlinelibrary.wiley.com/doi/10.1002/...

The orange line signifies the mean friction of the MTL group, and the green line signifies the mean friction of the Saline group.

Journal of Orthopaedic Research®@jorthopres.bsky.social · 7mo ago

Nataliya Tod & coauthors used high-resolution diffusion tensor MRI and simulation work to investigate collagen fiber architecture and glycosaminoglycan changes in knee cartilage after medial meniscus destabilization: onlinelibrary.wiley.com/doi/10.1002/...

Representative histology sections (b, e, g–j, m–p), their Modified Mankin scores (MMS, c, f), and the corresponding b0 images (a, d) in the medial knee compartment as well as the representative 3D tractography of a SHAM and DMM sample (k, l). The MMS values depicted were determined by assigning a score to the femoral and tibial cartilage for three consecutive sections, one of which is shown adjacent to the scores (b, e). The average of these three was reported here. Toluidine blue magnified images (g–j) are from the solid black (SHAM) and dashed black (DMM) boxes shown in b and e. The green arrow, white asterisk, and white arrow on DMM tibial cartilage highlight the roughened surface and cracks, the cellular disorganization, and the disrupted tidemark integrity, respectively. Picrosirius red magnified images (m–p) are from approximately the same boxed regions on an adjacent PSR stained sections. Black arrows highlight the organization of the SHAM tibial cartilage. The tractography images (k, l) show the 3D collagen fiber network for both the femur and tibia, primarily the central part (blue and red boxes shown in a and d). FC: femoral cartilage; TC: tibial cartilage; RZ: radial zone; SZ: superficial zone.

Journal of Orthopaedic Research®@jorthopres.bsky.social · 7mo ago

Cody C. Wyles & coauthors performed a novel identification of genetic variants in musculoskeletal pathways implicated in familial femoroacetabular impingement (FAI). These findings build our understanding of why FAI develops: onlinelibrary.wiley.com/doi/10.1002/...

Whole-exome sequencing reveals common genetic variants in family members diagnosed with FAI. Pedigrees of families under consideration for hereditary FAI. Square = male; Circle = female; filled = affected (A and B). Venn diagrams depicting genetic variants identified in each family, as well as overlapping variants between families (C–E).

Journal of Orthopaedic Research®@jorthopres.bsky.social · 7mo ago

Total joint replacement success relies on stable implant fixation. Joshua E. Johnson, Nico Verdonschot, Dennis Janssen & Donald D. Anderson highlight the importance of simulating press-fit implantation in finite element analysis in uncemented arthroplasty: onlinelibrary.wiley.com/doi/10.1002/...

Generalized representations of the TAA tibial component designs modeled, spanning the range of commercially available tibial fixation design features. Lateral tibial sidewall was resected for the keel implant model according to manufacturer guidelines.

Journal of Orthopaedic Research®@jorthopres.bsky.social · 7mo ago

Recent review by Puzhen Wu, Xinrui Liu, Ziyu Guo, & @lcmlau.bsky.social discusses "Personalization and Precision: Innovative Applications and Future Challenges of Additive Manufacturing in Orthopedic Implants". Check it out in JOR: onlinelibrary.wiley.com/doi/10.1002/...

Different AM processes vary in material compatibility, dimensional accuracy, mechanical properties, and biocompatibility. According to the American Society for Testing and Materials (ASTM), AM is classified into seven categories: Powder Bed Fusion (PBF), Material Extrusion (ME), Directed Energy Deposition (DED), Vat Photopolymerization (VP), Binder Jetting (BJ), Material Jetting (MJ) and Sheet Lamination (SL) [97]. These processes exhibit distinct advantages and limitations in orthopedic applications. Figure 2 illustrates these cutting-edge additive manufacturing technologies.

Journal of Orthopaedic Research®@jorthopres.bsky.social · 7mo ago

Peter W. Kurtz, Annsley Mace, Charley M. Goodwin, Jeremy L. Gilbert studied the effect of implant size on fretting currents of acetabular cup-liner tapers during in vitro cyclic loading: onlinelibrary.wiley.com/doi/10.1002/...

(A) A summary plot from one test (44 mm sample), which shows the analyzed baseline currents, the fretting currents and the difference between these, which yields the net fretting currents. (B) a 1 s sampling of the baseline currents while cyclic loading was paused. (C) One second of total currents sampled while cyclically loading. Note the 9 Hz current response in sync with the applied cyclic load. The average current of two baseline points (B), one before and after five fretting points, was subtracted from the average of the five fretting points (C) to calculate the net fretting currents (total current minus the baseline current).

Journal of Orthopaedic Research®@jorthopres.bsky.social · 7mo ago

Mechanical stress promotes tendon healing, but the optimal exercise protocol for rotator cuff healing is unknown. Haruna Misuo & coauthors examined the impact of postoperative exercise timing on tendon healing & muscle degeneration after rotator cuff tear: onlinelibrary.wiley.com/doi/10.1002/...

Study design. A total of 110 mice were randomly divided into 5 groups. Animals were sacrificed at 3 and 6 weeks postoperatively for histological and biomechanical analysis.

Journal of Orthopaedic Research®@jorthopres.bsky.social · 7mo ago

Bone marrow lesions (BMLs) occur in ~80% of anterior cruciate ligament injuries. Callie E. Stirling & coauthors found that BMLs vary by sex & fracture status, and relate to early symptoms: onlinelibrary.wiley.com/doi/10.1002/...

Flowchart outlining recruitment, exclusion, enrollment, imaging, and withdrawal processes for the study.

Journal of Orthopaedic Research®@jorthopres.bsky.social · 7mo ago

Rosemarijn van Paassen & coauthors found that patellar and femoral bone morphology Is associated with overweight and sports participation in young adolescents: onlinelibrary.wiley.com/doi/10.1002/...

Distance maps of the patella shape modes (1-7, 10 and 11) showing the distance (in millimeter) from the mean in the ±3 SD direction projected on the mean shape. The distance on the left side ranges from −4 to +4 mm and on the right ranges from −1 to +1 mm.

Journal of Orthopaedic Research®@jorthopres.bsky.social · 8mo ago

Learn about "Optical Imaging of Articular Cartilage: Current Status and Clinical Applications" in this Varun Gopinatth & coauthors: onlinelibrary.wiley.com/doi/10.1002/...

(a, b) Healthy cartilage visualized using PSOCT imaging correlates with (c, d) histological images; OCT images of (a) backscatter reflectivity showing a uniform signal and (b) phase retardation showing low birefringence; histological images showing (c) Picrosirius red stained section and (d) the same section under polarization microscopy demonstrating organized thick and thin collagen fibers on the surface and deeper zones respectfully (from Shyu et al. [35], reproduced courtesy of The Electromagnetics Academy).

Journal of Orthopaedic Research®@jorthopres.bsky.social · 8mo ago

Hiroyori Fusagawa & coauthors developed a rat model of overuse-induced muscle disorder. They observed mesenchymal stromal cell activation & fibrosis without injury, challenging the traditional concept that repetitive injury underlies overuse-induced fibrosis: onlinelibrary.wiley.com/doi/10.1002/...

In vivo MRI analysis of the longitudinal course of skeletal muscle affected by continuous ISO. Regarding the levels shown in the representative T2wi of the coronal plane on the far left: the joint surface level (A), 3.4 mm distal (B), 6.8 mm distal (C), 13.6 mm distal (D), and 20.4 mm distal (E) to the joint surface level, representative T2wi and T2*wi of the axial plane of the right lower leg in CTL, ISO 1w, ISO 2w, ISO 2w + SED 1w, ISO 2w + SED 3w, and ISO 2w + SED 4w, as well as schematic diagrams of the structures within the image (black indicates bones, blue indicates the lateral gastrocnemius muscle, green indicates the medial gastrocnemius muscle, red indicates the soleus muscle, and pink indicates the plantaris muscle), are shown. Arrowheads in T2*wi indicate a low-density area in the medial gastrocnemius muscle.

Journal of Orthopaedic Research®@jorthopres.bsky.social · 8mo ago

Tabea Schmid & coauthors studied the influence of age on a murine proximal femur fracture model in young and middle-aged mice and whether the model could be suitable to study the molecular mechanisms of age-related delayed fracture healing: onlinelibrary.wiley.com/doi/10.1002/...

$μCT-Analysis and fracture callus histomorphometry on d14: (A) bone volume; (B) callus tissue volume; (C) bone volume to callus tissue volume ration; (D) periosteal callus area; (E) relative bone area in the periosteal fracture callus; (F) relative cartilage area in the periosteal fracture callus of 12 and 52 week old mice; (G) representative 3D image of fractured femur of 12 week old mice; (H) representative 3D image of fractured femur of 52 week old mice; (I) relative area of fibrous tissue in the periosteal fracture callus of 12 and 52 week old mice; (J, K) representative image of fractured femurs stained with safranin O of 12 and 52 week old mice; (L) relative area of Collagen X positive tissue in the periosteal fracture callus of 12 and 52 week old mice; (M, N) representative image of fractured femurs of 12 and 52 week old mice stained for Collagen X. (n = 12; students t-test; *p < 0.05; **p < 0.01).$

Journal of Orthopaedic Research®@jorthopres.bsky.social · 8mo ago

Knee mid-flexion instability and paradoxical anterior femoral movement can be problematic after cruciate-sacrificing total knee arthoplasty. Maeruan Kebbach & coauthors used a simulation to see how optimized implant design responds to these challenges: onlinelibrary.wiley.com/doi/10.1002/...

Top: Depiction of the total knee replacement systems investigated in this study: P.F.C.™ Sigma® (DePuy), Columbus® UC (Aesculap), oneKNEE® CR/CS (Aesculap) and oneKNEE® MS (Aesculap). Bottom: Cross-sections of the femoral components (Columbus® UC and oneKNEE®) showing the different curvatures). Note that the tibial tray of P.F.C.™ Sigma® is thicker because a modified tray for the instrumented implant was used.

Journal of Orthopaedic Research®@jorthopres.bsky.social · 8mo ago

Arash Ghaffari & coauthors found that that frequency-based gait metrics from wearable sensors are sensitive digital biomarkers for short-term functional improvements after total knee arthroplasty: onlinelibrary.wiley.com/doi/10.1002/...

Illustration of wearable sensor placement on the lateral aspect of the thigh.

Journal of Orthopaedic Research®@jorthopres.bsky.social · 8mo ago

Anna E. Duncan & coauthors developed a machine learning model based on patient and radiographic parameters that could identify patients indicated for cementless total knee arthroplasty: onlinelibrary.wiley.com/doi/10.1002/...

Increased use of cementless primary TKA over the past decade in the AJRR 2024 Annual Report.

Journal of Orthopaedic Research®@jorthopres.bsky.social · 8mo ago

Check out "Reimagining Outcomes: A Perspective Review of Advances in Remote Monitoring Technologies in Post-Arthroplasty Patient Care", by Janie L. Astephen Wilson and Ryan M. Chapman: onlinelibrary.wiley.com/doi/10.1002/...

Overview of remote arthroplasty monitoring technologies including e-health/mobile applications, wearable sensors, smart implants, smart textiles, and smart homes.

Journal of Orthopaedic Research®@jorthopres.bsky.social · 8mo ago

Miriam G. E. Oldhoff & coauthors designed a standardized mechanical test setup and a corresponding finite element analysis to assess the stability and strength of both patient-specific and conventional implants for posterior wall acetabular fractures: onlinelibrary.wiley.com/doi/10.1002/...

Contour plots of the von Mises stress (MPa) of the synthetic bone of the PSI model (a) and conventional implant model (b) and the von Mises stress (MPa) of the PSI (c) and conventional implant model (d) under 3200N loading.

Journal of Orthopaedic Research®@jorthopres.bsky.social · 8mo ago

In total hip replacement, the anterior approach is theorized to cause less gluteal muscle disruption, leading to better recovery compared to the posterolateral approach. Jesse C. Christensen & coauthors evaluated differences in physical function recovery:

onlinelibrary.wiley.com

Journal of Orthopaedic Research®@jorthopres.bsky.social · 8mo ago

Donghwan Yoon & coauthors found that a single delayed injection of rhLubricin improved the quality and lubricating ability of the repair cartilage tissue without inhibiting repair tissue integration: onlinelibrary.wiley.com/doi/10.1002/...

Flowchart of study design and methods used to investigate the outcome measures of gross scoring, surface roughness, coefficient of friction, histology, and lubricin immunohistochemistry of the study.

Journal of Orthopaedic Research®@jorthopres.bsky.social · 8mo ago

R. Peter Suderman & coauthors evaluated the use of patient-specific 3D-printed drill guides to improve alignment in an ovine model of osteochondral allograft transplantation when used in place of a free-hand drilling technique: onlinelibrary.wiley.com/doi/10.1002/...

Steps for the design and manufacturing of 3D-printed patient-specific drill guides for ovine osteochondral allograft transplantation with an example of the guide design to highlight key features.

Journal of Orthopaedic Research®@jorthopres.bsky.social · 8mo ago

Check out "In Vivo Evaluation of Hemiarthroplasty Bearing Materials Using Animal Models: A Scoping Review (Part II)", by Landon M. Begin & coauthors in JOR: onlinelibrary.wiley.com/doi/10.1002/...

Breakdown of materials evaluated, with the number of studies evaluated for each (#) and the associated animal models used. (Note: 6 of the 24 studies were comparative studies that evaluated two or more HBMs). Titanium (Ti), Cobalt Chromium (CoCr), Stainless Steel (SS), Alumina Ceramic (AC), Pyrolytic Carbon (PyC), Partially Stabilized Zirconia (PSZ), Zirconia Dioxide (ZrO2), Polyetheretherketone (PEEK), Polyvinyl Alcohol (PVA).

Journal of Orthopaedic Research®@jorthopres.bsky.social · 8mo ago

Check out "Development of Reliable and High-Throughput Human Biomimetic Cartilage and Bone Models to Explore Senescence and Personalized Osteoarthritis Treatment Options" by Ilja Boone & coauthors in JOR: onlinelibrary.wiley.com/doi/10.1002/...

Experiment timeline of (A), the osteochondral explants; timeline of the irradiation (IR), hyperphysiological mechanical loading (ML), and combination (IR + ML) models. Bone and cartilage were separated for gene expression analysis. Before separation, cross-sections were taken for histology. (B) The high-throughput human in vitro cartilage organoids; timeline of the IR and harvest of the human in vitro mini cartilage organoid model. Complete pellets were taken for gene expression analysis and histology. Created with BioRender.com.

Journal of Orthopaedic Research®@jorthopres.bsky.social · 8mo ago

What is the influence of hip prosthesis position on postoperative gait after primary total hip arthroplasty in patients with unilateral femoral head necrosis? Yiming Wang & coauthors present their findings in JOR: onlinelibrary.wiley.com/doi/10.1002/...

Heat maps of the correlation between postoperative femoral anteversion and acetabular anteversion and gait.

Journal of Orthopaedic Research®@jorthopres.bsky.social · 8mo ago

Ann-Sofie Scheike & coauthors investigated the anti-inflammatory properties of liraglutide, a glucagon-like peptide 1 receptor agonists, in equine in vitro models and in an in vivo acute synovitis model in Shetland ponies: onlinelibrary.wiley.com/doi/10.1002/...

Visual overview outlining the experimental period including synovial fluid sampling and gait analysis time points. Eight clinically sound Shetland ponies were used in a placebo-controlled experiment where liraglutide and Ringer's solution were randomly assigned to their left and right intercarpal joints. Synovitis was induced with LPS injection, and arthrocentesis was performed at six time points, starting 96 h before and continuing after the LPS injection. Synovial fluid was collected and clinical assessments, including pain scoring, were conducted prior to each joint puncture, and every 24 h until 96 h. Potential analgesic effects were evaluated through quantitative gait analysis before and after the treatments.