New paper! While it has been known that DMS encodes more information than secondary structure, it has never really been characterized. So we did the first large study to look: 7,500 RNAs, all with known 3D structures. We found a lot of cool structural relationships. doi.org/10.1093/nar/...

Excited to announce a new collaborative preprint about a structural concept 'local stability compensation'. This states structurally important motifs must be flanked by more stable helices. We observe this effect natural occurring RNAs and experimentally evaluate it. www.biorxiv.org/content/10.1...

It's great to see the latest RNA puzzles paper has come out. www.nature.com/articles/s41... Its a must-read for those interested in RNA structure prediction!

RNA-Puzzles Round V: blind predictions of 23 RNA structures - Nature Methods

The results of the Fifth RNA-Puzzles contest highlights advances in RNA three-dimensional structure prediction and uncovers new insights into RNA folding and structure.

nature.com

🧬 Excited to share our new preprint! DMS chemical mapping, a key technique for studying RNA structure. Everyone assumes low DMS reactivity = Watson-Crick , high = non-WC. However, analyzing 7,500 RNA structures containing known 3D structures reveals it's not that simple. doi.org/10.1101/2024...

A quantitative framework for structural interpretation of DMS reactivity

Dimethyl sulfate (DMS) chemical mapping is widely used for probing RNA structure, with low reactivity interpreted as Watson-Crick (WC) base pairs and high reactivity as unpaired nucleotides. Despite i...

biorxiv.org

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