Really nice to be back on the beach for Lorne Infection & Immunity. Thanks to the organisers for a great meeting and the chance to share our work. Lorne was my first ever conference when I was a young student, and it's great to see the community going strong #lorneiandi

Thanks VIIN for the chance to share our work! Great to be back in sunny Lorne for this meeting

Victorian Infection and Immunity Network@theviin.bsky.social · 6mo ago

Moving on from UTIs, postdoc @joshnewson.bsky.social from @ethz.ch gave an interesting talk on developing Salmonella multimutants! They found that the SPI-2 type III secretion systems contribute to gut inflammation, systemic infection and pathogen transmission in various animal models 🧫 #lorneiandi

Happy to share our latest preprint: CRISPR base editors are a powerful tool for multiplexed gene editing in bacteria, but they also induce a range of off-target edits, and we show this can have a big impact on clonal fitness during infection. Online now! www.biorxiv.org/content/10.6...

Great to be back down under for the annual pilgrimage, this time bouncing across Melbourne, Sydney, and Adelaide 🌲☀️🌊

Thanks D-BIOL for highlighting our recent @natcomms.nature.com paper on intracellular Salmonella virulence. We hope these strains will be a useful resource for the field!

Department of Biology, ETH Zurich@eth-dbiol.bsky.social · 9mo ago

Intracellular Salmonella require T3SS effectors to cause infection. A study by the Hardt lab @ethz.ch ETH Zürich gives new insights into which bacterial factors are critical for infection in vivo, and provides new tools for researchers to further explore. More: biol.ethz.ch/en/news-and-...

Excited to share our latest work, where we create Salmonella mutants deficient for cohorts of SPI-2 T3SS effectors. These strains can be used to efficiently identify particular effectors that contribute to SPI-2 phenotypes doi.org/10.1038/s414...

Salmonella multimutants enable efficient identification of SPI-2 effector protein function in gut inflammation and systemic colonization - Nature Communications

Intracellular Salmonella enterica uses a type III secretion system to secrete more than 30 effector proteins into host cells. Here, Newson et al. generate six mutant strains deficient in different set...

doi.org

Many of you in #AcademicBsky in the northern hemisphere might not know the dire state of Australian academia. This essay by Andrew Dean is a fair snapshot of the state of the sector. Thinking today especially of academics in some Aus unis facing mass job cuts ~ 3,000 jobs on the chopping block now.

Dropping out, burning out, tuning out • Andrew Dean

Nobody’s happy about the state of Australian universities, but a seasoned academic has some remedies

insidestory.org.au

Great week of science in New Hampshire at the Salmonella GRS/GRC. Thanks to the chairs for their hard work. Really nice to see a strong Aussie cohort here too. Looking forward to 2027!

Excited to be traveling to New Hampshire USA for the GRC Salmonella meeting, looking forward to some great discussion. But, since I'm traveling on Swiss National Day, first a quick farewell Raclette 🇨🇭 🧀 🥂

Antibiotic-recalcitrant Salmonella exploits post-antibiotic microbiota disruption to achieve virulence-dependent transmission

Antibiotic-recalcitrant Salmonella exploits post-antibiotic microbiota disruption to achieve virulence-dependent transmission

Newson et al. show that antibiotics not only reduce Salmonella infection but also disrupt the gut microbiota, enabling relapse and transmission from tissue-lodged persister reservoirs. Relapse requires intracellular virulence factors and produces clonal populations. Microbiota transfer between hosts blocks pathogen relapse-associated blooms, revealing how the host-pathogen-microbiota axis shapes transmission.

dlvr.it

We're happy to share this example of how antibiotic treatment can promote clonal transmission of an invasive gut pathogen. We also explore the importance of preserving microbiota during treatment. Thanks to everyone who contributed to this paper! #MicroSky #IDSky www.cell.com/cell-reports...

Antibiotic-recalcitrant Salmonella exploits post-antibiotic microbiota disruption to achieve virulence-dependent transmission

Newson et al. show that antibiotics not only reduce Salmonella infection but also disrupt the gut microbiota, enabling relapse and transmission from tissue-lodged persister reservoirs. Relapse require...

cell.com

Really nice to be back in Australia for a couple of weeks, going through Brisbane, Melbourne, and Adelaide. Nice to trade snow for sunshine and catch up with friends, family, and colleagues around the country 🇦🇺 🍻 🌞

Excited to share this story describing new tools for studying Salmonella virulence. We engineered six multimutant strains to be deficient for different sets of SPI-2 T3SS effectors. We think there's lots of potential for new discoveries using these strains www.biorxiv.org/content/10.1...

Salmonella multimutants enable efficient identification of SPI-2 effector protein function in gut inflammation and systemic colonization

Salmonella enterica spp. rely on translocation of effector proteins through the SPI-2 encoded type III secretion system (T3SS) to achieve pathogenesis. More than 30 effectors contribute to manipulatio...

biorxiv.org

Coming to the end of a big week in Liverpool, great to share some of our work on pathogen transmission and antibiotic persistence. Thanks @jayhinton.bsky.social for hosting me at @liverpooluni.bsky.social and thanks to the Microbiology Society for the support to present at #FISHIS24