What links #brain structure and #nonsuicidal self-injury? 🧠 A large multi-site study finds that altered frontoparietal white matter integrity is associated with increased #motor impulsivity, which in turn mediates NSSI frequency 🩺 https://ow.ly/8FBi50Ziwrm

50 years of #discovery, and many unanswered questions remain 🧠 Submit research or reviews to our collection defining the future of #psychiatric #neuroscience, from mechanisms to clinical translation https://ow.ly/kgnn50Ziwhz Deadline: Jan 31, 2027

Can we predict who is at risk of clozapine-induced #myocarditis? 🧠❤️ Research using patient-derived stem cell #cardiomyocytes and #epigenomic profiling identifies #DNA methylation differences that may help explain vulnerability to this rare but serious adverse effect https://ow.ly/VP6450ZiwqB

The #brain doesn’t just “light up”—it reconfigures dynamically during #learning 🧠 In #schizophrenia, research shows these network dynamics are less flexible and more #random, and that this instability is linked to worse #symptoms and cognitive performance https://ow.ly/tXCw50Ziwqh

#NowHiring! We’re seeking an Institutional Account Manager (UK) with experience in sales to grow subscriptions and support institutional partnerships across key markets. Apply now: https://ow.ly/NiUp50ZlCig

Honouring excellence in #psychiatric #neuroscience 🧠 The Dr. Francis Wayne Quan Memorial #Prize recognizes outstanding research published in #JPN celebrating both scientific impact and the legacy of Dr. Quan, one of the journal’s founding editors https://ow.ly/a9Q950ZiwpR

A #rare and #distressing case in #neuropsychiatric treatment 🧠 Persistent #genital arousal disorder (PGAD) emerged during long-acting aripiprazole therapy and resolved after #medication change, highlighting a possible dopaminergic mechanism 💊 https://ow.ly/ImWO50Ziwpv

Where does #publishing revenue go? At JPN, it goes back into #science 🧪 As a #not-for-profit journal in #psychiatry and #neuroscience, we reinvest into supporting the research community and advancing the field! Publish with us today!📓 https://ow.ly/mGtZ50ZiwoX

What drives #hazardous #drinking most strongly? 🍺 #MachineLearning analysis of two datasets finds that incentive salience (reward value) and negative #emotionality (drinking to cope) are the strongest contributors, supporting the ANA dimensional framework of #addiction https://ow.ly/1UP450ZiwnP

A new #challenge in #digital #psychiatry: #AI chatbots and #psychosis 🤖 A case report describes how a personified #chatbot reinforced #delusional beliefs and undermined #antipsychotic adherence in a #patient with first-episode psychosis 🧠 https://ow.ly/fgGU50Ziwl3

How do we distinguish #drug #sideeffects from mood relapse in #bipolar #disorder? 🧠 A case report describes severe #restlessness, “buzzing” sensations, and manic-like symptoms following atomoxetine initiation in a patient with bipolar I disorder and #ADHD https://ow.ly/znCX50ZiwjC

Inhibition in #schizophrenia may be disrupted in “#time and #frequency.” New MEG evidence shows stage-specific low gamma alterations in the rIFG–preSMA circuit, revealing how fast-response control breaks down in early #psychosis https://ow.ly/jAUY50Ziwj7

How does #depression reshape #stress and #reward circuits in the #brain? New resting-state 7T fMRI data show reduced connectivity between the #BNST and ventral #striatum in individuals with MDD, suggesting altered communication in key affective circuits 🧠 https://ow.ly/KHzB50ZiwiG

How does #age of onset shape #brain function in #OCD? 🧠 Multimodal imaging data suggest shared thalamic alterations across OCD subtypes, while early-onset #cases show distinct changes in #occipital functional activity https://ow.ly/b0Sf50Ziwi5

What will define the next 50 years of #psychiatric #neuroscience? 🧠 Submit your research to our collection bridging mechanism and #clinic, from neural circuits to #biomarkers, computation, and treatment targets https://ow.ly/OufH50Ziwhi Deadline: Jan 31, 2027

#Clinical studies deserve a #journal that reaches both #clinicians and #neuroscientists 🧠⚕️ JPN publishes work across psychiatry and brain science with strong #visibility and a rigorous, expert-led #review process https://ow.ly/kl7V50Z6pE5

Can depression be understood as a “speed disorder”? 🧠⏱️ New perspective proposes that #depression may involve a core disturbance in the #speed of brain and behavioural processing This “abnormal slowness” could cut across #emotional, #cognitive, #motor, and #sensory symptoms https://ow.ly/RSZM50Z6qtl

#Smoking isn’t just habit—it’s #brain network dynamics 🧠🚬 New #research shows disrupted causal connectivity within default mode network subsystems is associated with #automatic smoking behaviour in #tobacco use #disorder 🩺 https://ow.ly/fSOG50Z6pJL

What happens in the #brain during #emotion regulation in #depression? 🧠 A new Journal of #Psychiatry and #Neuroscience meta-analysis maps consistent patterns of hyperactivity in emotion-related regions and reduced activity in #cognitive #control circuits https://ow.ly/IfVt50Z6qmi

#Knowledge as an intervention? 🧠📚 This JPN #editorial argues that #neuroscience #education may help empower individuals living with #addiction by explaining how #brain systems change with s#ubstance use and #recovery ❤️‍🩹 https://ow.ly/5ZLP50Z6pNF

How does the #gut influence the #aging #brain in #depression? 🧠🦠 A new Journal of #Psychiatry and #Neuroscience study links gut microbiota composition with altered brain functional connectivity in late-life depression 🧬 https://ow.ly/zK8x50Z6pUS

How do #psychedelics reshape the #brain — and experience? 🧠🌈 This JPN #review examines mechanisms from 5-HT2A receptor signaling to default mode #network modulation and #neuroplasticity 🧫 https://ow.ly/jMno50Z6q5t

The #immune system and #brain may be more connected than we think 🧠🛡️ New #research shows changes in peripheral T lymphocyte #aminoacid #metabolism in a #ketamine model of #schizophrenia - like behavior 🧬 https://ow.ly/58yk50Z6pAJ

How does the #brain distinguish self-generated actions from external events? 🧠👁️ A new study shows disrupted corollary discharge signalling during #eye movements in both #schizophrenia and #bipolar disorder with psychotic features 🔬 https://ow.ly/huTt50Z6pyA

Is #adult #neurogenesis in the #human hippocampus real—and how much is there? 🧠🔬 A spatial #transcriptomic analysis finds very low levels of hippocampal neurogenesis in humans, but suggests a potential “reserve” of #plasticity remains in the adult #brain https://ow.ly/jja750Z6qbJ

How do #psychiatric disorders shape #decision-making? 🧠🎲 A new Journal of #Psychiatry and #Neuroscience study compares model-based vs model-free learning across #depression, #OCD, and #schizophrenia — revealing both shared and disorder-specific patterns 🧐 https://ow.ly/7Shx50Z6pvj

Can #brain dynamics predict #treatment response in #panic disorder? 🧠⚡ A new Journal of #Psychiatry and #Neuroscience study finds that temporal variability in insula and lingual gyrus connectivity may help distinguish responders from non-responders early in treatment 💊 https://ow.ly/oOqm50Z6prB

New insights into the #neurochemistry of #psychosis progression 🧠⚡ ACC #glutamate levels differ across #genetic high-risk, clinical high-risk, and first-episode #schizophrenia — suggesting a non-linear trajectory across illness stages https://ow.ly/OwNh50Z6pnC

Some of the most memorable advances in #psychiatry start with a single #case 🧠🔬 We invite case study submissions that offer clear #clinical or #mechanistic insight into #brain and #behavior https://ow.ly/XkUw50Z6pb5

Toward early detection of #schizophrenia risk 🧠🔬 This study integrates MEG and #behavioral data to identify #neural signatures that may help stratify #clinical and familial risk 💊 https://ow.ly/O2S050Z6p5l