One day the US will have to face the shame and horror of what has happened here: that a cabal of wealthy people have elevated a monster into the most powerful person in the world www.nytimes.com/2025/11/12/u...

Epstein Alleged in Emails That Trump Knew of His Conduct

nytimes.com

I’m very happy to share Zhong Han’s beautiful work on the biochemical function of Senataxin, encoded by a gene that is mutated in rare and early-disabling neurodegenerative diseases. Turns out it rescues backtracked RNA polymerase II during early transcription! www.sciencedirect.com/science/arti...

A role for human senataxin in contending with pausing and backtracking during transcript elongation

Senataxin (SETX) regulates RNA polymerase II (RNAPII) transcription and helps maintain genome stability, at least partly by suppressing R-loops. Howev…

sciencedirect.com

I'm very happy to share this review, written with Dan Blears, on a new interpretation of promoter-proximal pausing in the context of a transcription checkpoint. We're not the only ones with these ideas, but they've not been sufficiently explored the way we do here: genesdev.cshlp.org/content/earl...

Extremely proud to share the impressive work done by Anouk Olthof et al. on how cells maintain healthy levels of RNAPII, and how they respond when levels are too low. Fascinating stuff, we think www.biorxiv.org/content/10.1...

Systems-level feedback loops maintain gene expression homeostasis following RNA polymerase II dosage perturbation

Transcription is regulated by sequence-specific transcription factors and enzymes allowing access to genes in chromatin. However, recent data indicate that the abundance of RNA polymerase II (RNAPII) ...

biorxiv.org

Excited to share our latest paper, now online in Molecular Cell. First, it shows that the RNAPII-CTD kinases CDK9 and CDK12 are Ser5-Ser2 kinases. Secondly, it describes the activation mechanism of CDK12/13 by PAF1C complex. Congratulations to David López Martínez and coauthors! lnkd.in/d_nbfMht

Danes offer to buy California to spite Trump’s Greenland aims: ‘We’ll bring hygge to Hollywood’

Danes offer to buy California to spite Trump’s Greenland aims: ‘We’ll bring hygge to Hollywood’

Satirical petition from Denmark, which owns Greenland, racks up 200,000 signatures as Trump eyes Arctic island Since returning to the presidency last month, Donald Trump has called for Canada to become the 51st US state, suggested he might take over the…

theguardian.com

Looking for 2 or more highly motivated PhD students to join our quest to understand the interplay between gene expression, genome instability, and human disease jobportal.ku.dk/phd/?show=16... Deadline: March 6, 2025 Please share

PhD fellowships at the Center for Gene Expression

jobportal.ku.dk

Setting up shop in advance of closing our profile on X.