I am pleased to share our new paper in Molecular Cell: “Capsid restructuring activates semi-conservative dsRNA transcription in cystovirus ɸ6.” We visualized, in structural detail, how a double-stranded RNA virus switches from a quiescent to a transcriptionally active state. Link in the comments

Excited to share our latest preprint "Capsid Restructuring Activates Semi-Conservative dsRNA Transcription in Cystovirus ɸ6". We show that nucleotide-triggered disassembly of the outer capsid layer is followed by expansion of the inner layer and the stepwise assembly of transcription complexes.

In our latest preprint on bioRxiv, we present the in situ structure of the human gap junction at 14 Å resolution using cryo-ET. The structure provides a blueprint for investigating how connexin regulation shapes intercellular communication in health and disease.