Julien Cherfils Vicini
@juliencherfils.bsky.social
Team Leader @ircaninstitute Passionated by immunosurveillance to fight aging and cancer
Ca y est, notre projet «Équipe labellisée FRM» démarre ! Objectif : restaurer l'immunosurveillance des cellules sénescentes pour prévenir les maladies liées à l'âge. Très reconnaissant à la @FRM_officiel, à ses donateurs et à son comité scientifique pour leur confiance ! @univcotedazur.bsky.social
Proud to share our latest preprint! We demonstrate that targeting the immune checkpoint GD3 with a short mid-life treatment leads to long-lasting health benefits (>1 year after treatment cessation). Kudos to @irynamoskalevska.bsky.social, to the ISAC team and collaborators @ircan.bsky.social
Targeting the senescence-associated immune checkpoint GD3 ganglioside extends healthspan and blunt age-related diseases with sex-specific benefits.
The accumulation and impact of senescent cells in age-related diseases are increasingly characterized. However, the mechanisms underlying their accumulation and their causative role in age-associated ...
biorxiv.org
bioRxivpreprint@biorxivpreprint.bsky.social · 8mo agoTargeting the senescence-associated immune checkpoint GD3 ganglioside extends healthspan and blunt age-related diseases with sex-specific benefits. https://www.biorxiv.org/content/10.64898/2026.01.06.697856v1
#RésultatScientifique🔎 | Vieillissement : un bouclier levé ? @juliencherfils.bsky.social et ses collaborateurs ont découvert comment un glycolipide protège les cellules sénescentes du système immunitaire. En le ciblant, ils parviennent à réduire les effets du vieillissement chez la souris ! 🧪
Une nouvelle cible pour lutter contre les maladies chroniques liées au vieillissement
Le vieillissement entraîne une accumulation de cellules sénescentes qui échappent au système immunitaire et contribuent à des maladies chroniques telles que l
buff.ly
Deeply honored by this News & Views! doi.org/10.1038/s435... Huge thanks to @Krizhanovsky, @Mejewska and @NatureAging.bsky.social for highlighting our paper rdcu.be/d6wko @ircaninstitute @Univ_CotedAzur @CNRsbiologie.bsky.social @Inserm.fr @iltischarlene.bsky.social @irynamoskalevska.bsky.social
GD3 ganglioside checkpoints in immune surveillance of senescent cells - Nature Aging
Iltis, Moskalevska and colleagues investigate how the innate immune system regulates the age-related accumulation of senescent cells. They show that upregulation of the GD3 ganglioside-based immune ch...
doi.org
Study shows that senescent cells literally sugar-coat themselves to avoid recognition and clearance by the immune system. www.nature.com/articles/s43...
A ganglioside-based immune checkpoint enables senescent cells to evade immunosurveillance during aging - Nature Aging
This study identifies a novel immune checkpoint in senescent cells that is linked to the ganglioside GD3 and that contributes to the evasion of immune clearance by these cells and to aging and age-rel...
nature.com
This paper, coupled with the Perspective from Neuron, really indicates that our understanding of the immune system on an aging brain could well be entering a new phase - one with lots of great data rather than mainly conjecture. www.cell.com/neuron/abstr...
Chronological versus immunological aging: Immune rejuvenation to arrest cognitive decline
Basurco and Abellanas et al. discuss how immune system aging negatively impacts the brain and propose immune rejuvenation as a strategy to combat cognitive decline and sustain lifelong brain health.
cell.com
Waggoner Lab@labwaggoner.bsky.social · 2y agoGD3 acts as a senescence immune checkpoint that allows senescent cells to escape immunosurveillance and to trigger immune anergy during aging www.nature.com/articles/s43... @natureaging.bsky.social @iltischarlene.bsky.social @irynamoskalevska.bsky.social
1/7 Excited to share our team’s first paper revealing how senescent cells use the GD3 ganglioside as a Senescence Immune Checkpoints (SICs) to bypass immune surveillance published in @NatureAging! rdcu.be/d4XXJ
A ganglioside-based immune checkpoint enables senescent cells to evade immunosurveillance during aging
Nature Aging - This study identifies a novel immune checkpoint in senescent cells that is linked to the ganglioside GD3 and that contributes to the evasion of immune clearance by these cells and to...
rdcu.be
What an incredible year! 🎉🚀 Huge thanks to my amazing team and collaborators! New talent, new lab under construction (moving in Jan 2025!), fantastic meetings (Chile, Shanghai) & paper accepted in @NatureAging (stay tuned!). Wishing everyone a Merry Christmas and an even more amazing 2025! 🎄✨
